MTH1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTH1_YEAST
• UniProt AC: P35198
• Protein Name: Protein MTH1
• Gene Name: MTH1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 433
• Protein Sequence: MFVSPPPATSKNQVLQRRPLESTNSNHGFASSLQAIPENTMSGSDNASFQSLPLSMSSSQSTTSSRRENFVNAPPEYTDRARDEIKKRLLASSPSRRSHHSSSMHSASRRSSVAESGSLLSDNASSYQSSIFSAPSTVHTQLTNDSSFSEFPNHKLITRVSLDEALPKTFYDMYSPDILLADPSNILCNGRPKFTKRELLDWDLNDIRSLLIVEKLRPEWGNQLPEVITVGDNMPQFRLQLLPLYSSDETIIATLVHSDLYMEANLDYEFKLTSAKYTVATARKRHEHITGRNEAVMNLSKPEWRNIIENYLLNIAVEAQCRFDFKQRCSEYKKWKLQQSNLKRPDMPPPSIIPRKNSTETKSLLKKALLKNIQLKNPNNNLDELMMRSSAATNQQGKNKVSLSKEEKATIWSQCQAQVYQRLGLDWQPDSVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
92	Phosphorylation	IKKRLLASSPSRRSH HHHHHHHCCCCHHCC	42.63	28889911
93	Phosphorylation	KKRLLASSPSRRSHH HHHHHHCCCCHHCCC	22.68	28889911
108	Phosphorylation	SSSMHSASRRSSVAE CHHCCCHHHHHCHHH	31.10	28889911
168	Ubiquitination	SLDEALPKTFYDMYS EHHHHCCHHHHHCCC	52.71	23749301
271	Ubiquitination	ANLDYEFKLTSAKYT ECCCEEEEECCCEEE	38.63	22817900
276	Ubiquitination	EFKLTSAKYTVATAR EEEECCCEEEHHHHH	41.02	23749301
301	Ubiquitination	EAVMNLSKPEWRNII HHHHHCCCHHHHHHH	50.55	23749301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	GRR1	P24814	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTH1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTH1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RGT1_YEAST	RGT1	physical	14508605
RGT2_YEAST	RGT2	physical	10632886
SNF3_YEAST	SNF3	physical	10632886
SNF3_YEAST	SNF3	physical	10373505
GRR1_YEAST	GRR1	physical	15456873
HXT1_YEAST	HXT1	genetic	8366037
HXT1_YEAST	HXT1	genetic	8002563
HXT2_YEAST	HXT2	genetic	8002563
HXT3_YEAST	HXT3	genetic	8366037
HXT3_YEAST	HXT3	genetic	8002563
HXT4_YEAST	HXT4	genetic	8366037
STD1_YEAST	STD1	genetic	19720826
AGP1_YEAST	AGP1	genetic	20093466
GET3_YEAST	GET3	genetic	20093466
VPS41_YEAST	VPS41	genetic	20093466
MED5_YEAST	NUT1	genetic	20093466
YG3A_YEAST	YGR130C	genetic	20093466
STP2_YEAST	STP2	genetic	20093466
VPS29_YEAST	VPS29	genetic	20093466
FMC1_YEAST	FMC1	genetic	20093466
CTK3_YEAST	CTK3	genetic	20093466
RCN2_YEAST	RCN2	genetic	20093466
YP264_YEAST	YPL264C	genetic	20093466
STD1_YEAST	STD1	genetic	9725828
STD1_YEAST	STD1	genetic	20959818
SUM1_YEAST	SUM1	genetic	20959818
URE2_YEAST	URE2	genetic	20959818
SPT3_YEAST	SPT3	genetic	20959818
STB5_YEAST	STB5	genetic	20959818
UPC2_YEAST	UPC2	genetic	20959818
GAT1_YEAST	GAT1	genetic	20959818
VHS1_YEAST	VHS1	genetic	21127252
STD1_YEAST	STD1	genetic	23234240
HXT2_YEAST	HXT2	genetic	23234240
TUP1_YEAST	TUP1	genetic	23468525
KAPA_YEAST	TPK1	genetic	23468525
PP4R3_YEAST	PSY2	physical	24277933
PP4C_YEAST	PPH3	physical	24277933
STD1_YEAST	STD1	genetic	26431967
STD1_YEAST	STD1	genetic	25541485
MRM2_YEAST	MRM2	genetic	27708008
MED5_YEAST	NUT1	genetic	27708008
YG3A_YEAST	YGR130C	genetic	27708008
VPS29_YEAST	VPS29	genetic	27708008
TOK1_YEAST	TOK1	genetic	27708008
RL8B_YEAST	RPL8B	genetic	27708008
CTK3_YEAST	CTK3	genetic	27708008
RCN2_YEAST	RCN2	genetic	27708008
CWC27_YEAST	CWC27	genetic	27708008
ELP3_YEAST	ELP3	genetic	27708008
MED1_YEAST	MED1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.