| UniProt ID | SUM1_YEAST | |
|---|---|---|
| UniProt AC | P46676 | |
| Protein Name | Suppressor of mar1-1 protein | |
| Gene Name | SUM1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1062 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | DNA-binding protein that specifically binds the regulatory region of middle sporulation genes (MSE). Required for the repression of middle sporulation genes during vegetative growth. Represses expression via the recruitment of histone deacetylase HST1.. | |
| Protein Sequence | MSENTTAPSDNITNEQRLPSGPKDDVDTLALTSAQNQANSLRKLDTDANAKALPSITDIPVSDDSDIKRQVGSGFGSNPLHIKDSEAFPHSSIEALKEGMDKVTKQCNDLKTALLSKDTSLTDSVQDLFNSLKVLSHNQSVLENKLDDVMKNQVNTDILVNNLNERLNKLSTMLQNTSKVNHSNLLIENSSNNTSSQHNTSSSRRGPGRPRKDASTSTMNKLVSNAASVNLKSASNQGAPFSPVNITLPTAVVQTSKSKRYFVEPSTKQESLLLSAPSSSRDDADMSLTSVPQRTNNENGKERPSTANSSSITPTPVTPNNLIQIKRKRGRPPKKRTVETMISNSTDTIDKSDASNRIKNEIPINSLLPSSKFHQIPSSPSNPVSQPAPVRTSRSATQEIDIKSLELASLISTNGDPNAEDSNTTDTVHNNVEGKVNVEENKTEKEKIITIKSSSENSGNNTTNNNNTDNVIKFSANSDINSDIRRLMVNDQFSLSYDASGNITVKLPPVSSPAAATAAAAAAVTSEMNRQQRELDKRRDSREKMLVNMKYNDRDKAKSFMESNKKLLKAMKEEERRKRMTSIIHDNHLNLNLNEISTRSKIKSAEKPTTKGSSMSPKPRSASISGISDHQQEGYQPLEQEKLVDIDNEGSNANSDSLKMGLTISAADTVHKVGIQSMLNSGEEAITKENAEYERKTPGDEETTTFVPLENSQPSDTIRKRTAGDDGALDQTENTSISPKKRRTEDHTKGEEDEGERGVGNSGTLATVENVSGDISADLSKGTSSIHNDTESANDSSNGNGNLGLGTESRNTLLTATPIELICREGFFYRRDIPDVPITTGAYLEFKFKAKEEELINSSINEEDYAAKSKHEKMNAHFFKPDIQEETELAFEILSKTTLTEKYVNSLEYFLMEFRWENKLVGLGLKLRESKRTWQRRKALFALFEFWRDQSRDKRRFHNYTILHAVKEMENYRIFINRSVSWFYNHITLLKMILYDLCDNVTTQWREWMFPHNETLPALGQDGINEDNLNETIDNMLIFDFLDDGSENNQVKYSRIIPPDIR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSENTTAPS ------CCCCCCCCC | 51.35 | 22814378 | |
| 2 | Phosphorylation | ------MSENTTAPS ------CCCCCCCCC | 51.35 | 19823750 | |
| 5 | Phosphorylation | ---MSENTTAPSDNI ---CCCCCCCCCCCC | 21.93 | 19823750 | |
| 6 | Phosphorylation | --MSENTTAPSDNIT --CCCCCCCCCCCCC | 48.42 | 19823750 | |
| 9 | Phosphorylation | SENTTAPSDNITNEQ CCCCCCCCCCCCCCC | 40.60 | 19823750 | |
| 13 | Phosphorylation | TAPSDNITNEQRLPS CCCCCCCCCCCCCCC | 38.67 | 19823750 | |
| 20 | Phosphorylation | TNEQRLPSGPKDDVD CCCCCCCCCCCCCHH | 72.77 | 23749301 | |
| 23 | Acetylation | QRLPSGPKDDVDTLA CCCCCCCCCCHHHHH | 70.82 | 25381059 | |
| 28 | Phosphorylation | GPKDDVDTLALTSAQ CCCCCHHHHHHHHHH | 17.49 | 23607784 | |
| 32 | Phosphorylation | DVDTLALTSAQNQAN CHHHHHHHHHHHHHH | 19.19 | 23607784 | |
| 33 | Phosphorylation | VDTLALTSAQNQANS HHHHHHHHHHHHHHH | 28.80 | 23607784 | |
| 40 | Phosphorylation | SAQNQANSLRKLDTD HHHHHHHHHHHCCCC | 32.35 | 23749301 | |
| 43 | Acetylation | NQANSLRKLDTDANA HHHHHHHHCCCCCCC | 56.88 | 25381059 | |
| 55 | Phosphorylation | ANAKALPSITDIPVS CCCCCCCCCCCCCCC | 38.68 | 22369663 | |
| 57 | Phosphorylation | AKALPSITDIPVSDD CCCCCCCCCCCCCCC | 32.01 | 22369663 | |
| 62 | Phosphorylation | SITDIPVSDDSDIKR CCCCCCCCCCHHHHH | 30.28 | 22369663 | |
| 65 | Phosphorylation | DIPVSDDSDIKRQVG CCCCCCCHHHHHHCC | 46.34 | 22369663 | |
| 73 | Phosphorylation | DIKRQVGSGFGSNPL HHHHHCCCCCCCCCC | 31.90 | 19823750 | |
| 77 | Phosphorylation | QVGSGFGSNPLHIKD HCCCCCCCCCCCCCC | 32.77 | 19823750 | |
| 105 | Acetylation | EGMDKVTKQCNDLKT HCHHHHHHHHHHHHH | 56.70 | 25381059 | |
| 215 | Phosphorylation | GRPRKDASTSTMNKL CCCCCCCCHHHHHHH | 32.78 | 28889911 | |
| 216 | Phosphorylation | RPRKDASTSTMNKLV CCCCCCCHHHHHHHH | 29.91 | 26447709 | |
| 217 | Phosphorylation | PRKDASTSTMNKLVS CCCCCCHHHHHHHHH | 24.14 | 23749301 | |
| 218 | Phosphorylation | RKDASTSTMNKLVSN CCCCCHHHHHHHHHC | 25.50 | 21440633 | |
| 224 | Phosphorylation | STMNKLVSNAASVNL HHHHHHHHCHHHCCC | 31.05 | 23749301 | |
| 228 | Phosphorylation | KLVSNAASVNLKSAS HHHHCHHHCCCCCCC | 14.77 | 23749301 | |
| 233 | Phosphorylation | AASVNLKSASNQGAP HHHCCCCCCCCCCCC | 39.84 | 30377154 | |
| 242 | Phosphorylation | SNQGAPFSPVNITLP CCCCCCCCCCEEECC | 27.21 | 28152593 | |
| 247 | Phosphorylation | PFSPVNITLPTAVVQ CCCCCEEECCCEEEE | 22.83 | 30377154 | |
| 250 | Phosphorylation | PVNITLPTAVVQTSK CCEEECCCEEEECCC | 34.89 | 21440633 | |
| 255 | Phosphorylation | LPTAVVQTSKSKRYF CCCEEEECCCCCCEE | 26.89 | 21440633 | |
| 289 | Phosphorylation | DDADMSLTSVPQRTN CCCCCCCCCCCCCCC | 22.00 | 27017623 | |
| 305 | Phosphorylation | ENGKERPSTANSSSI CCCCCCCCCCCCCCC | 46.50 | 23749301 | |
| 306 | Phosphorylation | NGKERPSTANSSSIT CCCCCCCCCCCCCCC | 32.32 | 22369663 | |
| 309 | Phosphorylation | ERPSTANSSSITPTP CCCCCCCCCCCCCCC | 24.01 | 22369663 | |
| 310 | Phosphorylation | RPSTANSSSITPTPV CCCCCCCCCCCCCCC | 26.10 | 22369663 | |
| 311 | Phosphorylation | PSTANSSSITPTPVT CCCCCCCCCCCCCCC | 30.24 | 22369663 | |
| 313 | Phosphorylation | TANSSSITPTPVTPN CCCCCCCCCCCCCCC | 24.06 | 22369663 | |
| 315 | Phosphorylation | NSSSITPTPVTPNNL CCCCCCCCCCCCCCC | 23.03 | 22369663 | |
| 318 | Phosphorylation | SITPTPVTPNNLIQI CCCCCCCCCCCCEEE | 22.85 | 22369663 | |
| 326 | Acetylation | PNNLIQIKRKRGRPP CCCCEEEHHHCCCCC | 35.18 | 25381059 | |
| 340 | Phosphorylation | PKKRTVETMISNSTD CCCCCHHHHHCCCCC | 18.57 | 30377154 | |
| 343 | Phosphorylation | RTVETMISNSTDTID CCHHHHHCCCCCCCC | 17.57 | 30377154 | |
| 345 | Phosphorylation | VETMISNSTDTIDKS HHHHHCCCCCCCCHH | 22.37 | 30377154 | |
| 348 | Phosphorylation | MISNSTDTIDKSDAS HHCCCCCCCCHHHHH | 31.03 | 30377154 | |
| 352 | Phosphorylation | STDTIDKSDASNRIK CCCCCCHHHHHHHHC | 34.36 | 23749301 | |
| 366 | Phosphorylation | KNEIPINSLLPSSKF CCCCCHHHCCCCCCC | 31.81 | 28889911 | |
| 372 | Acetylation | NSLLPSSKFHQIPSS HHCCCCCCCCCCCCC | 51.72 | 25381059 | |
| 378 | Phosphorylation | SKFHQIPSSPSNPVS CCCCCCCCCCCCCCC | 57.41 | 22369663 | |
| 379 | Phosphorylation | KFHQIPSSPSNPVSQ CCCCCCCCCCCCCCC | 27.30 | 22369663 | |
| 381 | Phosphorylation | HQIPSSPSNPVSQPA CCCCCCCCCCCCCCC | 56.57 | 22369663 | |
| 385 | Phosphorylation | SSPSNPVSQPAPVRT CCCCCCCCCCCCCCC | 31.53 | 22890988 | |
| 392 | Phosphorylation | SQPAPVRTSRSATQE CCCCCCCCCCCCCCE | 28.82 | 29136822 | |
| 393 | Phosphorylation | QPAPVRTSRSATQEI CCCCCCCCCCCCCEE | 17.42 | 29136822 | |
| 395 | Phosphorylation | APVRTSRSATQEIDI CCCCCCCCCCCEEEC | 35.12 | 22369663 | |
| 397 | Phosphorylation | VRTSRSATQEIDIKS CCCCCCCCCEEECCH | 28.16 | 22369663 | |
| 422 | Phosphorylation | GDPNAEDSNTTDTVH CCCCCCCCCCCCCCH | 27.81 | 23749301 | |
| 453 | Phosphorylation | EKIITIKSSSENSGN EEEEEEECCCCCCCC | 34.93 | 30377154 | |
| 455 | Phosphorylation | IITIKSSSENSGNNT EEEEECCCCCCCCCC | 48.14 | 30377154 | |
| 475 | Phosphorylation | TDNVIKFSANSDINS CCCEEEEECCCCCCH | 22.87 | 30377154 | |
| 478 | Phosphorylation | VIKFSANSDINSDIR EEEEECCCCCCHHHH | 39.31 | 30377154 | |
| 482 | Phosphorylation | SANSDINSDIRRLMV ECCCCCCHHHHHHHC | 34.45 | 30377154 | |
| 512 | Phosphorylation | VKLPPVSSPAAATAA EECCCCCCHHHHHHH | 20.84 | 21440633 | |
| 550 | Acetylation | EKMLVNMKYNDRDKA HHHHHHCCCCCHHHH | 35.38 | 25381059 | |
| 559 | Phosphorylation | NDRDKAKSFMESNKK CCHHHHHHHHHHHHH | 34.38 | 30377154 | |
| 565 | Acetylation | KSFMESNKKLLKAMK HHHHHHHHHHHHHHH | 54.82 | 25381059 | |
| 572 | Acetylation | KKLLKAMKEEERRKR HHHHHHHHHHHHHHH | 67.82 | 25381059 | |
| 604 | Phosphorylation | STRSKIKSAEKPTTK HHHHHHCCCCCCCCC | 45.17 | 27017623 | |
| 613 | Phosphorylation | EKPTTKGSSMSPKPR CCCCCCCCCCCCCCC | 25.15 | 21440633 | |
| 614 | Phosphorylation | KPTTKGSSMSPKPRS CCCCCCCCCCCCCCC | 31.76 | 19823750 | |
| 616 | Phosphorylation | TTKGSSMSPKPRSAS CCCCCCCCCCCCCCC | 31.55 | 19823750 | |
| 621 | Phosphorylation | SMSPKPRSASISGIS CCCCCCCCCCCCCCC | 34.59 | 22369663 | |
| 623 | Phosphorylation | SPKPRSASISGISDH CCCCCCCCCCCCCHH | 20.66 | 22369663 | |
| 625 | Phosphorylation | KPRSASISGISDHQQ CCCCCCCCCCCHHHH | 27.81 | 22890988 | |
| 628 | Phosphorylation | SASISGISDHQQEGY CCCCCCCCHHHHCCC | 32.34 | 22369663 | |
| 635 | Phosphorylation | SDHQQEGYQPLEQEK CHHHHCCCCCCHHHC | 13.25 | 22890988 | |
| 651 | Phosphorylation | VDIDNEGSNANSDSL CCCCCCCCCCCCCCC | 26.96 | 21551504 | |
| 655 | Phosphorylation | NEGSNANSDSLKMGL CCCCCCCCCCCCCCC | 26.60 | 28152593 | |
| 657 | Phosphorylation | GSNANSDSLKMGLTI CCCCCCCCCCCCCEE | 29.70 | 30377154 | |
| 681 | Phosphorylation | GIQSMLNSGEEAITK CHHHHHHCCCCCHHH | 43.55 | 28889911 | |
| 693 | Phosphorylation | ITKENAEYERKTPGD HHHHCHHHCCCCCCC | 20.72 | 17330950 | |
| 697 | Phosphorylation | NAEYERKTPGDEETT CHHHCCCCCCCCCCC | 38.43 | 22369663 | |
| 703 | Phosphorylation | KTPGDEETTTFVPLE CCCCCCCCCEEEECC | 29.14 | 22369663 | |
| 704 | Phosphorylation | TPGDEETTTFVPLEN CCCCCCCCEEEECCC | 22.86 | 22369663 | |
| 705 | Phosphorylation | PGDEETTTFVPLENS CCCCCCCEEEECCCC | 30.01 | 22369663 | |
| 712 | Phosphorylation | TFVPLENSQPSDTIR EEEECCCCCCCCCCC | 33.81 | 20190278 | |
| 715 | Phosphorylation | PLENSQPSDTIRKRT ECCCCCCCCCCCCCC | 39.48 | 28889911 | |
| 717 | Phosphorylation | ENSQPSDTIRKRTAG CCCCCCCCCCCCCCC | 27.33 | 24961812 | |
| 722 | Phosphorylation | SDTIRKRTAGDDGAL CCCCCCCCCCCCCCC | 37.72 | 19823750 | |
| 732 | Phosphorylation | DDGALDQTENTSISP CCCCCCCCCCCCCCC | 30.76 | 19823750 | |
| 735 | Phosphorylation | ALDQTENTSISPKKR CCCCCCCCCCCCCCC | 22.62 | 25521595 | |
| 736 | Phosphorylation | LDQTENTSISPKKRR CCCCCCCCCCCCCCC | 32.43 | 25521595 | |
| 738 | Phosphorylation | QTENTSISPKKRRTE CCCCCCCCCCCCCCC | 30.36 | 25521595 | |
| 783 | Phosphorylation | SADLSKGTSSIHNDT CCCCCCCCCCCCCCC | 24.04 | 22369663 | |
| 784 | Phosphorylation | ADLSKGTSSIHNDTE CCCCCCCCCCCCCCC | 35.64 | 22369663 | |
| 785 | Phosphorylation | DLSKGTSSIHNDTES CCCCCCCCCCCCCCC | 27.92 | 22369663 | |
| 790 | Phosphorylation | TSSIHNDTESANDSS CCCCCCCCCCCCCCC | 36.84 | 22369663 | |
| 792 | Phosphorylation | SIHNDTESANDSSNG CCCCCCCCCCCCCCC | 34.17 | 23749301 | |
| 796 | Phosphorylation | DTESANDSSNGNGNL CCCCCCCCCCCCCCC | 26.05 | 23749301 | |
| 797 | Phosphorylation | TESANDSSNGNGNLG CCCCCCCCCCCCCCC | 52.17 | 22369663 | |
| 817 | Phosphorylation | RNTLLTATPIELICR CCCEEEECCHHHHHC | 21.40 | 28152593 | |
| 858 | Phosphorylation | KEEELINSSINEEDY CHHHHHCCCCCHHHH | 26.12 | 23749301 | |
| 859 | Phosphorylation | EEELINSSINEEDYA HHHHHCCCCCHHHHH | 25.58 | 22369663 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SUM1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SUM1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-28; SER-55; THR-313;SER-378; SER-379; SER-381; THR-397; SER-614; SER-616; SER-621;SER-623; SER-628; SER-655; SER-681; THR-697; THR-705; SER-712;SER-715; SER-736; SER-738; THR-817 AND SER-859, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-378; SER-379; SER-381;SER-623; SER-712; SER-785 AND SER-859, AND MASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-623, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-697, AND MASSSPECTROMETRY. | |
