| UniProt ID | LAS17_YEAST | |
|---|---|---|
| UniProt AC | Q12446 | |
| Protein Name | Proline-rich protein LAS17 | |
| Gene Name | LAS17 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 633 | |
| Subcellular Localization | ||
| Protein Description | ||
| Protein Sequence | MGLLNSSDKEIIKRALPKASNKIIDVTVARLYIAYPDKNEWQYTGLSGALALVDDLVGNTFFLKLVDINGHRGVIWDQELYVNFEYYQDRTFFHTFEMEECFAGLLFVDINEASHFLKRVQKRERYANRKTLLNKNAVALTKKVREEQKSQVVHGPRGESLIDNQRKRYNYEDVDTIPTTKHKAPPPPPPTAETFDSDQTSSFSDINSTTASAPTTPAPALPPASPEVRKEETHPKHSLPPLPNQFAPLPDPPQHNSPPQNNAPSQPQSNPFPFPIPEIPSTQSATNPFPFPVPQQQFNQAPSMGIPQQNRPLPQLPNRNNRPVPPPPPMRTTTEGSGVRLPAPPPPPRRGPAPPPPPHRHVTSNTLNSAGGNSLLPQATGRRGPAPPPPPRASRPTPNVTMQQNPQQYNNSNRPFGYQTNSNMSSPPPPPVTTFNTLTPQMTAATGQPAVPLPQNTQAPSQATNVPVAPPPPPASLGQSQIPQSAPSAPIPPTLPSTTSAAPPPPPAFLTQQPQSGGAPAPPPPPQMPATSTSGGGSFAETTGDAGRDALLASIRGAGGIGALRKVDKSQLDKPSVLLQEARGESASPPAAAGNGGTPGGPPASLADALAAALNKRKTKVGAHDDMDNGDDW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 22 | Acetylation | ALPKASNKIIDVTVA HCHHCCCCEEEEEEE | 38.24 | 24489116 | |
| 160 | Phosphorylation | VHGPRGESLIDNQRK CCCCCCHHHHCCCHH | 33.19 | 21440633 | |
| 176 | Phosphorylation | YNYEDVDTIPTTKHK CCCCCCCCCCCCCCC | 28.80 | 21440633 | |
| 181 | Acetylation | VDTIPTTKHKAPPPP CCCCCCCCCCCCCCC | 45.66 | 24489116 | |
| 197 | Phosphorylation | PTAETFDSDQTSSFS CCCCCCCCCCCCCCC | 27.68 | 21551504 | |
| 201 | Phosphorylation | TFDSDQTSSFSDINS CCCCCCCCCCCCCCC | 24.61 | 21551504 | |
| 204 | Phosphorylation | SDQTSSFSDINSTTA CCCCCCCCCCCCCCC | 39.26 | 21551504 | |
| 210 | Phosphorylation | FSDINSTTASAPTTP CCCCCCCCCCCCCCC | 20.59 | 21551504 | |
| 212 | Phosphorylation | DINSTTASAPTTPAP CCCCCCCCCCCCCCC | 32.46 | 21551504 | |
| 216 | Phosphorylation | TTASAPTTPAPALPP CCCCCCCCCCCCCCC | 19.18 | 21551504 | |
| 225 | Phosphorylation | APALPPASPEVRKEE CCCCCCCCHHHHCCC | 27.63 | 27214570 | |
| 332 | Phosphorylation | PPPPPMRTTTEGSGV CCCCCCCCCCCCCCC | 31.64 | 22369663 | |
| 333 | Phosphorylation | PPPPMRTTTEGSGVR CCCCCCCCCCCCCCC | 16.69 | 22369663 | |
| 334 | Phosphorylation | PPPMRTTTEGSGVRL CCCCCCCCCCCCCCC | 37.42 | 22369663 | |
| 337 | Phosphorylation | MRTTTEGSGVRLPAP CCCCCCCCCCCCCCC | 28.08 | 22369663 | |
| 363 | Phosphorylation | PPPHRHVTSNTLNSA CCCCCCCCCCCCCCC | 15.33 | 28152593 | |
| 364 | Phosphorylation | PPHRHVTSNTLNSAG CCCCCCCCCCCCCCC | 27.08 | 19779198 | |
| 366 | Phosphorylation | HRHVTSNTLNSAGGN CCCCCCCCCCCCCCC | 27.38 | 19779198 | |
| 369 | Phosphorylation | VTSNTLNSAGGNSLL CCCCCCCCCCCCCCC | 31.25 | 19779198 | |
| 374 | Phosphorylation | LNSAGGNSLLPQATG CCCCCCCCCCCCCCC | 34.26 | 21440633 | |
| 380 | Phosphorylation | NSLLPQATGRRGPAP CCCCCCCCCCCCCCC | 26.44 | 23749301 | |
| 574 | Acetylation | VDKSQLDKPSVLLQE CCHHHCCCCCHHHHH | 48.02 | 24489116 | |
| 576 | Phosphorylation | KSQLDKPSVLLQEAR HHHCCCCCHHHHHHC | 31.01 | 21551504 | |
| 586 | Phosphorylation | LQEARGESASPPAAA HHHHCCCCCCCCHHH | 36.55 | 17563356 | |
| 588 | Phosphorylation | EARGESASPPAAAGN HHCCCCCCCCHHHCC | 40.47 | 21082442 | |
| 598 | Phosphorylation | AAAGNGGTPGGPPAS HHHCCCCCCCCCCHH | 21.84 | 21551504 | |
| 605 | Phosphorylation | TPGGPPASLADALAA CCCCCCHHHHHHHHH | 29.84 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LAS17_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LAS17_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LAS17_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-588, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-586 AND SER-588, ANDMASS SPECTROMETRY. | |
