RIFK_YEAST - dbPTM
RIFK_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RIFK_YEAST
UniProt AC Q03778
Protein Name Riboflavin kinase
Gene Name FMN1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 218
Subcellular Localization Microsome . Mitochondrion inner membrane . Endoplasmic reticulum . 90% microsomal. 10% mitochondrial. Found to be present in the inner membrane of mitochondria. The C-terminus is located in the matrix.
Protein Description Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme..
Protein Sequence MFTWTIYVSLLLVLAGTFLMNRNTNTDIIDTFKREVDLPIPAQPGPPFPLVTDYCDIVCGFGRGSAELGIPTANVPINQLPKGINDLDLGVYFGFAHIKTVDGQELSVETRRDGRTVVYNYGQYLSEANDDLSVLPMVLSVGKNPFYGNDFKTMELHIIHDFKNDFYGARVKFNILGHIRPELNYTTKEALIEDINIDIRTAQTVLATPPYQVFKQQL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MFTWTIYVSL
-----CCHHHHHHHH		22.0228132839
5Phosphorylation---MFTWTIYVSLLL
---CCHHHHHHHHHH		10.2028132839
7Phosphorylation-MFTWTIYVSLLLVL
-CCHHHHHHHHHHHH		4.0728889911
17PhosphorylationLLLVLAGTFLMNRNT
HHHHHHHHHHHCCCC		14.1628132839
147PhosphorylationSVGKNPFYGNDFKTM
EECCCCCCCCCCCCE		19.1028152593
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RIFK_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RIFK_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RIFK_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UTP5_YEASTUTP5physical
10688190
PIG2_YEASTPIG2genetic
19269370
6PGD1_YEASTGND1genetic
21623372
TGL2_YEASTTGL2genetic
21623372
ELO2_YEASTELO2genetic
21623372
FOLE_YEASTMET7genetic
21623372
DCOR_YEASTSPE1genetic
21623372
PFKA1_YEASTPFK1genetic
21623372
ADH3_YEASTADH3genetic
21623372
APC11_YEASTAPC11genetic
27708008
RPN5_YEASTRPN5genetic
27708008
GLE1_YEASTGLE1genetic
27708008
TIM22_YEASTTIM22genetic
27708008
FAL1_YEASTFAL1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
MED6_YEASTMED6genetic
27708008
PRP19_YEASTPRP19genetic
27708008
TAD3_YEASTTAD3genetic
27708008
RSC9_YEASTRSC9genetic
27708008
ERO1_YEASTERO1genetic
27708008
MCM1_YEASTMCM1genetic
27708008
DYR_YEASTDFR1genetic
27708008
TIM50_YEASTTIM50genetic
27708008
DCOR_YEASTSPE1genetic
27708008
EIF3J_YEASTHCR1genetic
27708008
SIW14_YEASTSIW14genetic
27708008
PHO80_YEASTPHO80genetic
27708008
YME1_YEASTYME1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RIFK_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-147, AND MASSSPECTROMETRY.

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