| UniProt ID | FOLE_YEAST | |
|---|---|---|
| UniProt AC | Q08645 | |
| Protein Name | Folylpolyglutamate synthase | |
| Gene Name | MET7 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 548 | |
| Subcellular Localization | Mitochondrion . Mitochondrion inner membrane. Mitochondrion matrix. Cytoplasm . | |
| Protein Description | Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Required for methionine synthesis and maintenance of intact mitochondrial DNA. Involved in telomere maintenance.. | |
| Protein Sequence | MHKGKKNYPNLITSFRMNLKKIILNHDRFSHPERWKTNALLRFTFVYIKFLFDLMIIKNPLRMVGKTYRDAVTALNSLQSNYANIMAIRQTGDRKNTMTLLEMHEWSRRIGYSASDFNKLNIVHITGTKGKGSTAAFTSSILGQYKEQLPRIGLYTSPHLKSVRERIRINGEPISEEKFAKYFFEVWDRLDSTTSSLDKFPHMIPGSKPGYFKFLTLLSFHTFIQEDCKSCVYEVGVGGELDSTNIIEKPIVCGVTLLGIDHTFMLGDTIEEIAWNKGGIFKSGAPAFTVEKQPPQGLTILKERAEERKTTLTEVPPFKQLENVKLGIAGEFQKSNASLAVMLASEILHTSNILEEKIKCSSNASIPEKFIIGLQNTKWEGRCQVLEKGKNVWYIDGAHTKDSMVAASTWFRDMVRLSKRKKILLFNQQSRDANALVNNLYSSVSPEITFDDVIFTTNVTWKSGSYSADLVSMNTSQEDVEKLKVQESLVKNWNKIDDNRAKTHVTASIEEANELIETLYDEPADIFVTGSLHLVGGLLVVFDRIDVK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 161 | Acetylation | LYTSPHLKSVRERIR CCCCHHHHHHHHHHE | 43.82 | 24489116 | |
| 178 | Acetylation | GEPISEEKFAKYFFE CEECCHHHHHHHHHH | 46.71 | 24489116 | |
| 292 | Acetylation | APAFTVEKQPPQGLT CCCEEEECCCCCCEE | 64.86 | 24489116 | |
| 378 | Acetylation | IIGLQNTKWEGRCQV EEEECCCCEECCEEE | 51.28 | 24489116 | |
| 394 | Phosphorylation | EKGKNVWYIDGAHTK ECCCCEEEEECCCCH | 5.71 | 19795423 | |
| 400 | Phosphorylation | WYIDGAHTKDSMVAA EEEECCCCHHHHHHH | 35.69 | 19795423 | |
| 403 | Phosphorylation | DGAHTKDSMVAASTW ECCCCHHHHHHHHHH | 19.40 | 19795423 | |
| 408 | Phosphorylation | KDSMVAASTWFRDMV HHHHHHHHHHHHHHH | 19.21 | 19823750 | |
| 409 | Phosphorylation | DSMVAASTWFRDMVR HHHHHHHHHHHHHHH | 24.72 | 19823750 | |
| 418 | Phosphorylation | FRDMVRLSKRKKILL HHHHHHHHHCCEEEE | 21.61 | 19823750 | |
| 472 | Phosphorylation | SYSADLVSMNTSQED CEEEEEEECCCCHHH | 17.38 | 28152593 | |
| 475 | Phosphorylation | ADLVSMNTSQEDVEK EEEEECCCCHHHHHH | 24.12 | 24961812 | |
| 476 | Phosphorylation | DLVSMNTSQEDVEKL EEEECCCCHHHHHHH | 26.94 | 28889911 | |
| 482 | Acetylation | TSQEDVEKLKVQESL CCHHHHHHHHHHHHH | 54.15 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FOLE_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FOLE_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FOLE_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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