TMT1_YEAST - dbPTM
TMT1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TMT1_YEAST
UniProt AC P32643
Protein Name Trans-aconitate 3-methyltransferase
Gene Name TMT1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 299
Subcellular Localization Cytoplasm .
Protein Description Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate and 3-isopropylmalate at high affinity and of other molecules like cis-aconitate, isocitrate, and citrate at lower velocities and affinities. The function of trans-aconitate methylation appears to be in reducing the toxicity of this spontaneous breakdown product of cis-aconitate. The role of 3-isopropylmalate methylation is unclear but may represent a metabolic branch at 3-isopropylmalate, where some of the material is taken in the pathway leading to leucine and some is taken in a pathway to the 3-isopropylmalate methyl ester, a molecule that provides a signal to switch from vegetative to invasive growth in response to amino acid starvation..
Protein Sequence MSTFSASDFNSERYSSSRPSYPSDFYKMIDEYHDGERKLLVDVGCGPGTATLQMAQELKPFEQIIGSDLSATMIKTAEVIKEGSPDTYKNVSFKISSSDDFKFLGADSVDKQKIDMITAVECAHWFDFEKFQRSAYANLRKDGTIAIWGYADPIFPDYPEFDDLMIEVPYGKQGLGPYWEQPGRSRLRNMLKDSHLDPELFHDIQVSYFCAEDVRDKVKLHQHTKKPLLIRKQVTLVEFADYVRTWSAYHQWKQDPKNKDKEDVADWFIKESLRRRPELSTNTKIEVVWNTFYKLGKRV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSTFSASDF
------CCCCCHHHC		37.8522814378
14PhosphorylationSDFNSERYSSSRPSY
HHCCCCCCCCCCCCC		14.6228889911
16PhosphorylationFNSERYSSSRPSYPS
CCCCCCCCCCCCCCH		22.7922369663
17PhosphorylationNSERYSSSRPSYPSD
CCCCCCCCCCCCCHH		42.1222369663
20PhosphorylationRYSSSRPSYPSDFYK
CCCCCCCCCCHHHHH		48.8722369663
21PhosphorylationYSSSRPSYPSDFYKM
CCCCCCCCCHHHHHH		14.9422369663
23PhosphorylationSSRPSYPSDFYKMID
CCCCCCCHHHHHHHH		31.9222369663
26PhosphorylationPSYPSDFYKMIDEYH
CCCCHHHHHHHHHHC		12.4922369663
70PhosphorylationQIIGSDLSATMIKTA
HHHCCCCCHHHHHHH		27.0427017623
84PhosphorylationAEVIKEGSPDTYKNV
HHHHCCCCCCCCCCE		22.2422369663
87PhosphorylationIKEGSPDTYKNVSFK
HCCCCCCCCCCEEEE		39.5222369663
88PhosphorylationKEGSPDTYKNVSFKI
CCCCCCCCCCEEEEE		14.1421440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TMT1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TMT1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TMT1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HRR25_YEASTHRR25physical
21460040
ADE_YEASTAAH1genetic
21623372
COX9_YEASTCOX9genetic
21623372
CYC1_YEASTCYC1genetic
21623372
AATC_YEASTAAT2genetic
21623372
ADH1_YEASTADH1genetic
21623372
ARGJ_YEASTARG7genetic
21623372
THRC_YEASTTHR4genetic
21623372
COX5A_YEASTCOX5Agenetic
21623372
JLP1_YEASTJLP1genetic
21623372
MDHC_YEASTMDH2genetic
21623372
GGPPS_YEASTBTS1genetic
21623372
ETR1_YEASTETR1genetic
21623372
CDA2_YEASTCDA2genetic
21623372
PPT2_YEASTPPT2genetic
21623372
LCF1_YEASTFAA1genetic
21623372
ATG8_YEASTATG8genetic
27708008
HPC2_YEASTHPC2genetic
27708008
MCH1_YEASTMCH1genetic
27708008
MSRA_YEASTMXR1genetic
27708008
MON1_YEASTMON1genetic
27708008
TBP7_YEASTYTA7genetic
27708008
HTD2_YEASTHTD2genetic
27708008
MTC6_YEASTMTC6genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
MTC2_YEASTMTC2genetic
27708008
CBT1_YEASTCBT1genetic
27708008
RT109_YEASTRTT109genetic
27708008
ARV1_YEASTARV1genetic
27708008
YMC0_YEASTYML020Wgenetic
27708008
YMW4_YEASTYMR074Cgenetic
27708008
GCSP_YEASTGCV2genetic
27708008
MNT4_YEASTMNT4genetic
27708008
DCAM_YEASTSPE2genetic
27708008
ATG29_YEASTATG29genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TMT1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-14; SER-17; SER-20;SER-84 AND THR-87, AND MASS SPECTROMETRY.

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