ETR1_YEAST - dbPTM
ETR1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ETR1_YEAST
UniProt AC P38071
Protein Name Enoyl-[acyl-carrier-protein] reductase, mitochondrial {ECO:0000305}
Gene Name ETR1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 380
Subcellular Localization Mitochondrion matrix .
Protein Description Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Required for respiration and the maintenance of the mitochondrial compartment..
Protein Sequence MLPTFKRYMSSSAHQIPKHFKSLIYSTHEVEDCTKVLSVKNYTPKQDLSQSIVLKTLAFPINPSDINQLQGVYPSRPEKTYDYSTDEPAAIAGNEGVFEVVSLPSGSSKGDLKLGDRVIPLQANQGTWSNYRVFSSSSDLIKVNDLDLFSAATVSVNGCTGFQLVSDYIDWNSNGNEWIIQNAGTSSVSKIVTQVAKAKGIKTLSVIRDRDNFDEVAKVLEDKYGATKVISESQNNDKTFAKEVLSKILGENARVRLALNSVGGKSSASIARKLENNALMLTYGGMSKQPVTLPTSLHIFKGLTSKGYWVTEKNKKNPQSKIDTISDFIKMYNYGHIISPRDEIETLTWNTNTTTDEQLLELVKKGITGKGKKKMVVLEW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
43PhosphorylationVLSVKNYTPKQDLSQ
EEECCCCCCCCCCCH		33.1423749301
45AcetylationSVKNYTPKQDLSQSI
ECCCCCCCCCCCHHH		48.9524489116
135PhosphorylationWSNYRVFSSSSDLIK
CCCEEEEECCCCEEE		26.8422369663
136PhosphorylationSNYRVFSSSSDLIKV
CCEEEEECCCCEEEE		23.5422369663
137PhosphorylationNYRVFSSSSDLIKVN
CEEEEECCCCEEEEC		27.0322369663
138PhosphorylationYRVFSSSSDLIKVND
EEEEECCCCEEEECC		38.0822369663
218AcetylationDNFDEVAKVLEDKYG
CCHHHHHHHHHHHHC		53.1524489116
238SuccinylationSESQNNDKTFAKEVL
ECHHCCCHHHHHHHH		47.9023954790
238AcetylationSESQNNDKTFAKEVL
ECHHCCCHHHHHHHH		47.9024489116
242AcetylationNNDKTFAKEVLSKIL
CCCHHHHHHHHHHHH		44.1324489116
242SuccinylationNNDKTFAKEVLSKIL
CCCHHHHHHHHHHHH		44.1323954790
247AcetylationFAKEVLSKILGENAR
HHHHHHHHHHCCCHH		37.4824489116
265AcetylationALNSVGGKSSASIAR
EEECCCCCCHHHHHH		35.0022865919
288AcetylationLTYGGMSKQPVTLPT
EEECCCCCCCCCCCC		50.1324489116
292PhosphorylationGMSKQPVTLPTSLHI
CCCCCCCCCCCEEEE		33.4322369663
295PhosphorylationKQPVTLPTSLHIFKG
CCCCCCCCEEEECCC		47.2122369663
296PhosphorylationQPVTLPTSLHIFKGL
CCCCCCCEEEECCCC		18.9321440633
301SuccinylationPTSLHIFKGLTSKGY
CCEEEECCCCCCCCE		53.0223954790
301AcetylationPTSLHIFKGLTSKGY
CCEEEECCCCCCCCE		53.0224489116
306AcetylationIFKGLTSKGYWVTEK
ECCCCCCCCEEECCC		51.2724489116
339PhosphorylationYNYGHIISPRDEIET
HCCCCCCCCHHHEEE		17.1812614607
368PhosphorylationELVKKGITGKGKKKM
HHHHCCCCCCCCCCE		41.3227017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ETR1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ETR1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ETR1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SSB1_YEASTSSB1physical
19536198
RIM15_YEASTRIM15genetic
20093466
GCN1_YEASTGCN1genetic
20093466
XRN1_YEASTXRN1genetic
20093466
AROC_YEASTARO2genetic
20093466
ASK10_YEASTASK10genetic
20093466
TRS65_YEASTTRS65genetic
20093466
SERB_YEASTSER2genetic
20093466
RS27B_YEASTRPS27Bgenetic
20093466
FYV10_YEASTFYV10genetic
20093466
EST3_YEASTEST3genetic
20093466
HUL4_YEASTHUL4genetic
20093466
HOC1_YEASTHOC1genetic
20093466
PTK1_YEASTPTK1genetic
20093466
RL14A_YEASTRPL14Agenetic
20093466
IRS4_YEASTIRS4genetic
20093466
EI2BA_YEASTGCN3genetic
20093466
YK104_YEASTYKR104Wgenetic
20093466
SLX4_YEASTSLX4genetic
20093466
GTR1_YEASTGTR1genetic
20093466
SMA2_YEASTSMA2genetic
20093466
PEX12_YEASTPEX12genetic
20093466
GID8_YEASTGID8genetic
20093466
LSM7_YEASTLSM7genetic
20093466
CYB5_YEASTCYB5genetic
20093466
PHO23_YEASTPHO23genetic
20093466
SIW14_YEASTSIW14genetic
20093466
PABS_YEASTABZ1genetic
20093466
BRE5_YEASTBRE5genetic
20093466
DCAM_YEASTSPE2genetic
20093466
SUCA_YEASTLSC1genetic
20093466
RS10A_YEASTRPS10Agenetic
20093466
ALG5_YEASTALG5genetic
20093466
SGF11_YEASTSGF11genetic
20093466
FABG_YEASTOAR1genetic
21623372
ARGJ_YEASTARG7genetic
21623372
GCSH_YEASTGCV3genetic
21623372
ALDH5_YEASTALD5genetic
21623372
QCR9_YEASTQCR9genetic
21623372
ATF2_YEASTATF2genetic
21623372
ELO3_YEASTELO3genetic
22808036
PTK1_YEASTPTK1genetic
22282571
ERF3_YEASTSUP35genetic
27708008
YD239_YEASTYDR239Cgenetic
27708008
PCL6_YEASTPCL6genetic
27708008
RRP1_YEASTRRP1genetic
27708008
CDC37_YEASTCDC37genetic
27708008
UTP5_YEASTUTP5genetic
27708008
COG3_YEASTCOG3genetic
27708008
KTHY_YEASTCDC8genetic
27708008
CDC11_YEASTCDC11genetic
27708008
BOS1_YEASTBOS1genetic
27708008
TAD3_YEASTTAD3genetic
27708008
LST8_YEASTLST8genetic
27708008
PRP4_YEASTPRP4genetic
27708008
KCC4_YEASTKCC4genetic
27708008
AGP1_YEASTAGP1genetic
27708008
MRC1_YEASTMRC1genetic
27708008
THRC_YEASTTHR4genetic
27708008
OCA4_YEASTOCA4genetic
27708008
RPN4_YEASTRPN4genetic
27708008
GPR1_YEASTGPR1genetic
27708008
MCH1_YEASTMCH1genetic
27708008
PEX19_YEASTPEX19genetic
27708008
KAR_YEASTYDL124Wgenetic
27708008
HOSM_YEASTLYS21genetic
27708008
ARO1_YEASTARO1genetic
27708008
WDR59_YEASTMTC5genetic
27708008
UME6_YEASTUME6genetic
27708008
PEX5_YEASTPEX5genetic
27708008
GNTK_YEASTYDR248Cgenetic
27708008
PEX10_YEASTPEX10genetic
27708008
LSM6_YEASTLSM6genetic
27708008
HKR1_YEASTHKR1genetic
27708008
KFA_YEASTBNA7genetic
27708008
GMC1_YEASTGMC1genetic
27708008
CAJ1_YEASTCAJ1genetic
27708008
GPP2_YEASTGPP2genetic
27708008
ODPA_YEASTPDA1genetic
27708008
YFF1_YEASTYFL051Cgenetic
27708008
AROC_YEASTARO2genetic
27708008
MED5_YEASTNUT1genetic
27708008
PEX14_YEASTPEX14genetic
27708008
XRN1_YEASTXRN1genetic
27708008
GCN1_YEASTGCN1genetic
27708008
PAU13_YEASTPAU13genetic
27708008
VPS53_YEASTVPS53genetic
27708008
PYR1_YEASTURA2genetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
EI2BA_YEASTGCN3genetic
27708008
GTR1_YEASTGTR1genetic
27708008
SIW14_YEASTSIW14genetic
27708008
OCA2_YEASTOCA2genetic
27708008
LSM7_YEASTLSM7genetic
27708008
DCAM_YEASTSPE2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ETR1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-135 AND SER-339, ANDMASS SPECTROMETRY.

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