dbPTM

ATF2_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ATF2_YEAST
UniProt AC	P53296
Protein Name	Alcohol O-acetyltransferase 2 {ECO:0000303\|PubMed:10103065}
Gene Name	ATF2 {ECO:0000303\|PubMed:10103065}
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	535
Subcellular Localization	Lipid droplet . Endoplasmic reticulum membrane Peripheral membrane protein . Traffics to lipid droplets during the stationary phase (PubMed:25093817).
Protein Description	Can use acetyl-CoA to synthesize acetate esters from various alcohols, producing ethyl acetate, isoamyl acetate, isobutyl acetate, butyl acetate, hexyl acetate, heptyl acetate and octyl acetate. [PubMed: 12957907]
Protein Sequence	MEDIEGYEPHITQELIDRGHARRMGHLENYFAVLSRQKMYSNFTVYAELNKGVNKRQLMLVLKVLLQKYSTLAHTIIPKHYPHHEAYYSSEEYLSKPFPQHDFIKVISHLEFDDLIMNNQPEYREVMEKISEQFKKDDFKVTNRLIELISPVIIPLGNPKRPNWRLICLPGKDTDGFETWKNFVYVTNHCGSDGVSGSNFFKDLALLFCKIEEKGFDYDEEFIEDQVIIDYDRDYTEISKLPKPITDRIDYKPALTSLPKFFLTTFIYEHCNFKTSSESTLTARYSPSSNANASYNYLLHFSTKQVEQIRAQIKKNVHDGCTLTPFIQACFLVALYRLDKLFTKSLLEYGFDVAIPSNARRFLPNDEELRDSYKYGSNVGGSHYAYLISSFDIPEGDNDKFWSLVEYYYDRFLESYDNGDHLIGLGVLQLDFIVENKNIDSLLANSYLHQQRGGAIISNTGLVSQDTTKPYYVRDLIFSQSAGALRFAFGLNVCSTNVNGMNMDMSVVQGTLRDRGEWESFCKLFYQTIGEFASL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
304	Ubiquitination	YLLHFSTKQVEQIRA EEEEEEHHHHHHHHH	51.66	23749301
441	Phosphorylation	VENKNIDSLLANSYL ECCCCHHHHHHHHHH	22.83	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ATF2_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ATF2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ATF2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YG3A_YEAST	YGR130C	physical	16554755
TSC3_YEAST	TSC3	genetic	16269340
PCY1_YEAST	PCT1	genetic	16269340
UPPS_YEAST	NUS1	genetic	16269340
GAS1_YEAST	GAS1	genetic	16269340
HAC1_YEAST	HAC1	genetic	16269340
OST6_YEAST	OST6	genetic	16269340
ATC6_YEAST	SPF1	genetic	16269340
ARV1_YEAST	ARV1	genetic	16269340
IRE1_YEAST	IRE1	genetic	16269340
TVP15_YEAST	TVP15	physical	18719252
TVP18_YEAST	TVP18	physical	18719252
PRA1_YEAST	YIP3	physical	18719252
RAD33_YEAST	RAD33	physical	18719252
YIF1_YEAST	YIF1	physical	18719252
PRM8_YEAST	PRM8	physical	18719252
GGPPS_YEAST	BTS1	genetic	21623372
ARO1_YEAST	ARO1	genetic	21623372
PPT2_YEAST	PPT2	genetic	21623372
DCOR_YEAST	SPE1	genetic	21623372
GSH1_YEAST	GSH1	genetic	21623372
ADH2_YEAST	ADH2	genetic	21623372
THRC_YEAST	THR4	genetic	21623372
ODPA_YEAST	PDA1	genetic	21623372
GCSH_YEAST	GCV3	genetic	21623372
ADH3_YEAST	ADH3	genetic	21623372
LCB5_YEAST	LCB5	genetic	21623372
ATPO_YEAST	ATP5	genetic	21623372
ATPF_YEAST	ATP4	genetic	21623372
COQ4_YEAST	COQ4	genetic	21623372
AATC_YEAST	AAT2	genetic	21623372
FLO9_YEAST	FLO9	genetic	23891562
FAL1_YEAST	FAL1	genetic	27708008
RSP5_YEAST	RSP5	genetic	27708008
CDC11_YEAST	CDC11	genetic	27708008
ATF1_YEAST	ATF1	genetic	27618952
PHO4_YEAST	PHO4	genetic	27618952
PHO81_YEAST	PHO81	genetic	27618952
PHO90_YEAST	PHO90	genetic	27618952
RTN3_HUMAN	RTN3	physical	27107014
RTN4_HUMAN	RTN4	physical	27107014
WAC_HUMAN	WAC	physical	27107014
PRAF1_HUMAN	RABAC1	physical	27107014
AR6P1_HUMAN	ARL6IP1	physical	27107014

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ATF2_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-441, AND MASSSPECTROMETRY.	18407956 [Abstract]