LCB5_YEAST - dbPTM
LCB5_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LCB5_YEAST
UniProt AC Q06147
Protein Name Sphingoid long chain base kinase 5
Gene Name LCB5
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 687
Subcellular Localization Golgi apparatus membrane
Peripheral membrane protein .
Protein Description Catalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS or sphinganine) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1-phosphate (PHS-1P) respectively. Redundant to LCB4, is only responsible for few percent of the total activity. Involved in the biosynthesis of sphingolipids and ceramides. Involved in heat-induced transient cell cycle arrest. Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling. Involved in heat-stress resistance..
Protein Sequence MTLKPSKRRKGRSRHSRKKQITSAILTEEGIMIKAKPSSPYTYANRMADKRSRSSIDNISRTSFQSNISRTSFQSNSDNNSIFETASLISCVTCLSDTDTIDRSETSTTDTSKDDLSANPKLHYPSVNGQLPANTVIPYGRILDARYIEKEPLHYYDANSSPSSPLSSSMSNISEKCDLDELESSQKKERKGNSLSRGSNSSSSLLTSRSPFTKLVEVIFARPRRHDVVPKRVSLYIDYKPHSSSHLKEEDDLVEEILKRSYKNTRRNKSIFVIINPFGGKGKAKKLFMTKAKPLLLASRCSIEVVYTKYPGHAIEIAREMDIDKYDTIACASGDGIPHEVINGLYQRPDHVKAFNNIAITEIPCGSGNAMSVSCHWTNNPSYSTLCLIKSIETRIDLMCCSQPSYAREHPKLSFLSQTYGLIAETDINTEFIRWMGPARFELGVAFNIIQKKKYPCEIYVKYAAKSKNELKNHYLEHKNKGSLEFQHITMNKDNEDCDNYNYENEYETENEDEDEDADADDEDSHLISRDLADSSADQIKEEDFKIKYPLDEGIPSDWERLDPNISNNLGIFYTGKMPYVAADTKFFPAALPSDGTMDMVITDARTSLTRMAPILLGLDKGSHVLQPEVLHSKILAYKIIPKLGNGLFSVDGEKFPLEPLQVEIMPRLCKTLLRNGRYVDTDFDSM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
38PhosphorylationIMIKAKPSSPYTYAN
CEEEECCCCCCHHHH		43.1527017623
39PhosphorylationMIKAKPSSPYTYANR
EEEECCCCCCHHHHH		30.3821440633
52PhosphorylationNRMADKRSRSSIDNI
HHHCCCCCHHHHCHH		42.1022369663
54PhosphorylationMADKRSRSSIDNISR
HCCCCCHHHHCHHHH		32.6522369663
55PhosphorylationADKRSRSSIDNISRT
CCCCCHHHHCHHHHH		32.6222369663
60PhosphorylationRSSIDNISRTSFQSN
HHHHCHHHHHHHHCC		35.4423749301
62PhosphorylationSIDNISRTSFQSNIS
HHCHHHHHHHHCCCC		27.4022369663
63PhosphorylationIDNISRTSFQSNISR
HCHHHHHHHHCCCCC		21.8522369663
66PhosphorylationISRTSFQSNISRTSF
HHHHHHHCCCCCCCC		33.8322369663
69PhosphorylationTSFQSNISRTSFQSN
HHHHCCCCCCCCCCC		33.4822369663
91S-palmitoylationETASLISCVTCLSDT
HHHHHHHHHHHCCCC		2.02-
94S-palmitoylationSLISCVTCLSDTDTI
HHHHHHHHCCCCCCC		1.38-
106PhosphorylationDTIDRSETSTTDTSK
CCCCCCCCCCCCCCH		32.4028889911
107PhosphorylationTIDRSETSTTDTSKD
CCCCCCCCCCCCCHH		25.8428889911
109PhosphorylationDRSETSTTDTSKDDL
CCCCCCCCCCCHHHC		36.7319779198
111PhosphorylationSETSTTDTSKDDLSA
CCCCCCCCCHHHCCC		35.2728889911
112PhosphorylationETSTTDTSKDDLSAN
CCCCCCCCHHHCCCC		36.5828889911
113UbiquitinationTSTTDTSKDDLSANP
CCCCCCCHHHCCCCC		58.3023749301
147PhosphorylationGRILDARYIEKEPLH
CEEEEEEEEECCCCC		18.3617330950
155PhosphorylationIEKEPLHYYDANSSP
EECCCCCEECCCCCC		15.6622369663
156PhosphorylationEKEPLHYYDANSSPS
ECCCCCEECCCCCCC		9.6122369663
160PhosphorylationLHYYDANSSPSSPLS
CCEECCCCCCCCCCH		45.4020377248
161PhosphorylationHYYDANSSPSSPLSS
CEECCCCCCCCCCHH		28.7120377248
163PhosphorylationYDANSSPSSPLSSSM
ECCCCCCCCCCHHHC		46.6820377248
164PhosphorylationDANSSPSSPLSSSMS
CCCCCCCCCCHHHCC		32.9922369663
167PhosphorylationSSPSSPLSSSMSNIS
CCCCCCCHHHCCCHH		24.6122369663
168PhosphorylationSPSSPLSSSMSNISE
CCCCCCHHHCCCHHH		37.4320377248
169PhosphorylationPSSPLSSSMSNISEK
CCCCCHHHCCCHHHH		23.8920377248
171PhosphorylationSPLSSSMSNISEKCD
CCCHHHCCCHHHHCC		32.7222369663
174PhosphorylationSSSMSNISEKCDLDE
HHHCCCHHHHCCHHH		34.9422369663
184PhosphorylationCDLDELESSQKKERK
CCHHHHHHHHHHHHC		51.1730377154
194PhosphorylationKKERKGNSLSRGSNS
HHHHCCCCCCCCCCC		36.0721440633
196PhosphorylationERKGNSLSRGSNSSS
HHCCCCCCCCCCCCH		34.1224961812
199PhosphorylationGNSLSRGSNSSSSLL
CCCCCCCCCCCHHHH		32.2122369663
201PhosphorylationSLSRGSNSSSSLLTS
CCCCCCCCCHHHHHC		33.0422369663
202PhosphorylationLSRGSNSSSSLLTSR
CCCCCCCCHHHHHCC		28.3522369663
203PhosphorylationSRGSNSSSSLLTSRS
CCCCCCCHHHHHCCC		25.4822369663
204PhosphorylationRGSNSSSSLLTSRSP
CCCCCCHHHHHCCCC		29.3722369663
207PhosphorylationNSSSSLLTSRSPFTK
CCCHHHHHCCCCCHH		27.6422369663
208PhosphorylationSSSSLLTSRSPFTKL
CCHHHHHCCCCCHHH		30.6322369663
503PhosphorylationEDCDNYNYENEYETE
CCCCCCCCCCCCCCC		15.1226447709
507PhosphorylationNYNYENEYETENEDE
CCCCCCCCCCCCCCC		39.4719779198
509PhosphorylationNYENEYETENEDEDE
CCCCCCCCCCCCCCC		43.1128889911
535PhosphorylationISRDLADSSADQIKE
HHHHHCCCCCHHHHH		23.0928889911
686PhosphorylationYVDTDFDSM------
CCCCCCCCC------		26.7821440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LCB5_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LCB5_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LCB5_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MNN10_YEASTMNN10genetic
19269370
GET2_YEASTGET2genetic
19269370
PUR7_YEASTADE1genetic
20093466
CSG2_YEASTCSG2genetic
20093466
PP2C4_YEASTPTC4genetic
20093466
ADP1_YEASTADP1genetic
20093466
ATG9_YEASTATG9genetic
20093466
PAA1_YEASTPAA1genetic
20093466
TRS85_YEASTTRS85genetic
20093466
UME6_YEASTUME6genetic
20093466
ERD1_YEASTERD1genetic
20093466
SWI4_YEASTSWI4genetic
20093466
RTF1_YEASTRTF1genetic
20093466
AAKG_YEASTSNF4genetic
20093466
CGR1_YEASTCGR1genetic
20093466
COG7_YEASTCOG7genetic
20093466
RS27B_YEASTRPS27Bgenetic
20093466
MED20_YEASTSRB2genetic
20093466
CYP7_YEASTCPR7genetic
20093466
VPS55_YEASTVPS55genetic
20093466
MRT4_YEASTMRT4genetic
20093466
IRS4_YEASTIRS4genetic
20093466
ENT4_YEASTENT4genetic
20093466
YL415_YEASTYLR415Cgenetic
20093466
YOX1_YEASTYOX1genetic
20093466
RSF1_YEASTRSF1genetic
20093466
BUB2_YEASTBUB2genetic
20093466
OSW5_YEASTOSW5genetic
20093466
MSS11_YEASTMSS11genetic
20093466
YM59_YEASTYMR209Cgenetic
20093466
SKY1_YEASTSKY1genetic
20093466
YHM2_YEASTYHM2genetic
20093466
SCS7_YEASTSCS7genetic
20093466
GOT1_YEASTGOT1genetic
20093466
AF9_YEASTYAF9genetic
20093466
ASI3_YEASTASI3genetic
20093466
ATG3_YEASTATG3genetic
20093466
HUB1_YEASTHUB1genetic
20093466
HOL1_YEASTHOL1genetic
20093466
BSC5_YEASTBSC5genetic
20093466
HST1_YEASTHST1genetic
20093466
YAP7_YEASTYAP7genetic
20093466
MDM12_YEASTMDM12genetic
20093466
TOP1_YEASTTOP1genetic
20093466
YO019_YEASTYOR019Wgenetic
20093466
GYP1_YEASTGYP1genetic
20093466
DIA2_YEASTDIA2genetic
20093466
YOR97_YEASTYOR097Cgenetic
20093466
VPS17_YEASTVPS17genetic
20093466
LCB4_YEASTLCB4genetic
20093466
ULS1_YEASTULS1genetic
20093466
PEX27_YEASTPEX27genetic
20093466
SLK19_YEASTSLK19genetic
20093466
RUD3_YEASTRUD3genetic
20093466
FABD_YEASTMCT1genetic
20093466
DSE3_YEASTDSE3genetic
20093466
RDL2_YEASTRDL2genetic
20093466
RAX1_YEASTRAX1genetic
20093466
YO304_YEASTBIL1genetic
20093466
MRN1_YEASTMRN1genetic
20093466
CARP_YEASTPEP4genetic
20093466
SUR1_YEASTSUR1genetic
20093466
ERV2_YEASTERV2genetic
20093466
TKT1_YEASTTKL1genetic
20093466
WSC4_YEASTWSC4genetic
20526336
TOR2_YEASTTOR2genetic
20526336
SRS2_YEASTSRS2genetic
21459050
CSG2_YEASTCSG2genetic
21623372
RPE_YEASTRPE1genetic
21623372
SUR1_YEASTSUR1genetic
21623372
GGPPS_YEASTBTS1genetic
21623372
SCS7_YEASTSCS7genetic
21623372
BUB1_YEASTBUB1genetic
21127252
KDX1_YEASTKDX1genetic
21127252
ADA2_YEASTADA2genetic
21127252
SWI4_YEASTSWI4genetic
21127252
HSL1_YEASTHSL1genetic
21127252
RAD51_YEASTRAD51genetic
21127252
PP4C_YEASTPPH3genetic
21127252
DOT6_YEASTDOT6genetic
21127252
IXR1_YEASTIXR1genetic
21127252
CTK1_YEASTCTK1genetic
21127252
OPI1_YEASTOPI1genetic
21127252
SEC1_YEASTSEC1genetic
21987634
YEH7_YEASTYEL067Cgenetic
21987634
GET2_YEASTGET2genetic
21987634
GUP1_YEASTGUP1genetic
21987634
IRS4_YEASTIRS4genetic
21987634
BET3_YEASTBET3genetic
21987634
RIC1_YEASTRIC1genetic
21987634
ERG2_YEASTERG2genetic
21987634
SCS7_YEASTSCS7genetic
21987634
COG6_YEASTCOG6genetic
21987634
TLG2_YEASTTLG2genetic
21987634
GET2_YEASTGET2genetic
23891562
TRS20_YEASTTRS20genetic
23891562
YPT1_YEASTYPT1genetic
23891562
TLG2_YEASTTLG2genetic
23891562
GYP1_YEASTGYP1genetic
23891562
RGP1_YEASTRGP1genetic
23891562
RIC1_YEASTRIC1genetic
23891562
COG8_YEASTCOG8genetic
23891562
RUD3_YEASTRUD3genetic
23891562
CANB_YEASTCNB1genetic
23891562
MSMO_YEASTERG25genetic
23891562
HMCS_YEASTERG13genetic
23891562
SEC18_YEASTSEC18genetic
23891562
HSF_YEASTHSF1genetic
23891562
GPI13_YEASTGPI13genetic
23891562
PROF_YEASTPFY1genetic
23891562
CSG2_YEASTCSG2genetic
23891562
SUR1_YEASTSUR1genetic
23891562
THIL_YEASTERG10genetic
23891562
MSS11_YEASTMSS11genetic
27708008
YM59_YEASTYMR209Cgenetic
27708008
YO13A_YEASTYOL013W-Agenetic
27708008
VPS17_YEASTVPS17genetic
27708008
LCB4_YEASTLCB4genetic
27708008
EAF3_YEASTEAF3genetic
27708008
SEC17_YEASTSEC17genetic
27708008
KPC1_YEASTPKC1genetic
27708008
CALM_YEASTCMD1genetic
27708008
MED8_YEASTMED8genetic
27708008
CDC37_YEASTCDC37genetic
27708008
COG3_YEASTCOG3genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
ATC7_YEASTNEO1genetic
27708008
MOB1_YEASTMOB1genetic
27708008
HMCS_YEASTERG13genetic
27708008
GPI12_YEASTGPI12genetic
27708008
NOP2_YEASTNOP2genetic
27708008
DCP2_YEASTDCP2genetic
27708008
MED4_YEASTMED4genetic
27708008
TBF1_YEASTTBF1genetic
27708008
PUR7_YEASTADE1genetic
27708008
PP2C4_YEASTPTC4genetic
27708008
NHP10_YEASTNHP10genetic
27708008
ATG9_YEASTATG9genetic
27708008
PAA1_YEASTPAA1genetic
27708008
TRS85_YEASTTRS85genetic
27708008
UME6_YEASTUME6genetic
27708008
ERD1_YEASTERD1genetic
27708008
SNF1_YEASTSNF1genetic
27708008
SWI4_YEASTSWI4genetic
27708008
COG7_YEASTCOG7genetic
27708008
AAKG_YEASTSNF4genetic
27708008
RTF1_YEASTRTF1genetic
27708008
RS27B_YEASTRPS27Bgenetic
27708008
MED20_YEASTSRB2genetic
27708008
HTD2_YEASTHTD2genetic
27708008
VPS53_YEASTVPS53genetic
27708008
CYP7_YEASTCPR7genetic
27708008
VPS55_YEASTVPS55genetic
27708008
MRT4_YEASTMRT4genetic
27708008
IRS4_YEASTIRS4genetic
27708008
VPS51_YEASTVPS51genetic
27708008
RSF1_YEASTRSF1genetic
27708008
OSW5_YEASTOSW5genetic
27708008
YHM2_YEASTYHM2genetic
27708008
SCS7_YEASTSCS7genetic
27708008
ADH2_YEASTADH2genetic
27708008
MAS5_YEASTYDJ1genetic
27708008
HUB1_YEASTHUB1genetic
27708008
YAP7_YEASTYAP7genetic
27708008
YO019_YEASTYOR019Wgenetic
27708008
PEX27_YEASTPEX27genetic
27708008
RUD3_YEASTRUD3genetic
27708008
RAX1_YEASTRAX1genetic
27708008
YO304_YEASTBIL1genetic
27708008
SUR1_YEASTSUR1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
CARP_YEASTPEP4genetic
27708008
ERV2_YEASTERV2genetic
27708008
TKT1_YEASTTKL1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LCB5_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39; SER-168; SER-169;SER-171; SER-201; SER-202 AND SER-204, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55, AND MASSSPECTROMETRY.

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