DOT6_YEAST - dbPTM
DOT6_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DOT6_YEAST
UniProt AC P40059
Protein Name Transcriptional regulatory protein DOT6
Gene Name DOT6
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 670
Subcellular Localization Nucleus .
Protein Description Component of the RPD3 histone deacetylase complex RPD3C(L) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. DOT6 binds to sequences containing the core CGATG, which resembles the PAC (Polymerase A and C) motif..
Protein Sequence MSISTSLNSASIHLSSMDTHPQLHSLTRQPHSSSTAMSKNEAQESSPSLPASSSSSTSASASASSKNSSKNPSSWDPQDDLLLRHLKEVKKMGWKDISQYFPNRTPNACQFRWRRLKSGNLKSNKTALIDINTYTGPLKITHGDETANAQQKPSKKVEENVLTEDTAEFTTTSSIPIPSRKTSLPSFHASMSFSQSPSNVTPTTIVSNAASSMPFAPPTLPAALPHHPHQHLHHHPHHKTLKPRSNSHSFTNSLNQDPIVRSNDEEKYGFIPKVFVRSRRSSFAYPQQVAITTTPSSPNSSHVLLSSKSRRGSLANWSRRSSFNVSSNNTSRRSSMILAPNSVSNIFNVNNSGSNTASTSNTNSRRESVIKKEFQQRLNNLSNSGGPTSNNGPIFPNSYTFMDLPHSSSVSSSSTLHKSKRGSFSGHSMKSSCNPTNLWSKDEDALLMENKKRNLSVMELSILLPQRTEVEIQWRLNALSSDADMLSPTHSPQKTLSKKTCPRMFKSGSTTDDDKGSDKEDVMGDGSNDDDEDNVDPLHRAKQSSNKTVFSSSSSNISSKDVSPDPIFSPDPADDSSNTSDAGSRCTITSDTSSSAATMNRTPNSKNPQDIALLNNFRSEAITPRPKPSSTTTSITTETTNNMINHSSSTTTTTNNSPLPSINTIFKDML
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
33PhosphorylationLTRQPHSSSTAMSKN
HHCCCCCCCCCCCHH		28.7728889911
34PhosphorylationTRQPHSSSTAMSKNE
HCCCCCCCCCCCHHH		24.1728889911
35PhosphorylationRQPHSSSTAMSKNEA
CCCCCCCCCCCHHHH		28.4727017623
39UbiquitinationSSSTAMSKNEAQESS
CCCCCCCHHHHHHCC		45.8022106047
45PhosphorylationSKNEAQESSPSLPAS
CHHHHHHCCCCCCCC		35.1523749301
46PhosphorylationKNEAQESSPSLPASS
HHHHHHCCCCCCCCC		20.1128889911
48PhosphorylationEAQESSPSLPASSSS
HHHHCCCCCCCCCCC		49.2724961812
66UbiquitinationASASASSKNSSKNPS
CCCCCCCCCCCCCCC		59.3524961812
70AcetylationASSKNSSKNPSSWDP
CCCCCCCCCCCCCCH		73.1022865919
73PhosphorylationKNSSKNPSSWDPQDD
CCCCCCCCCCCHHHH		54.1523749301
74PhosphorylationNSSKNPSSWDPQDDL
CCCCCCCCCCHHHHH		36.4321440633
87UbiquitinationDLLLRHLKEVKKMGW
HHHHHHHHHHHHCCC		55.1024961812
139AcetylationNTYTGPLKITHGDET
CCCCCCEEEECCCHH		49.0122865919
156UbiquitinationAQQKPSKKVEENVLT
CCCCCCCCHHHCCCC		60.2523749301
163PhosphorylationKVEENVLTEDTAEFT
CHHHCCCCCCCCEEE		27.7723749301
170PhosphorylationTEDTAEFTTTSSIPI
CCCCCEEEECCCCCC		22.2223749301
172PhosphorylationDTAEFTTTSSIPIPS
CCCEEEECCCCCCCC		19.8823749301
179PhosphorylationTSSIPIPSRKTSLPS
CCCCCCCCCCCCCCC		47.3223749301
240PhosphorylationHHHPHHKTLKPRSNS
CCCCCCCCCCCCCCC		35.3424961812
242UbiquitinationHPHHKTLKPRSNSHS
CCCCCCCCCCCCCCC		43.5524961812
245PhosphorylationHKTLKPRSNSHSFTN
CCCCCCCCCCCCCCC		51.7322369663
247PhosphorylationTLKPRSNSHSFTNSL
CCCCCCCCCCCCCCC		23.0422369663
249PhosphorylationKPRSNSHSFTNSLNQ
CCCCCCCCCCCCCCC		33.3222369663
251PhosphorylationRSNSHSFTNSLNQDP
CCCCCCCCCCCCCCC		27.2322369663
253PhosphorylationNSHSFTNSLNQDPIV
CCCCCCCCCCCCCCC		26.1622890988
262PhosphorylationNQDPIVRSNDEEKYG
CCCCCCCCCCHHHHC		37.4321440633
267UbiquitinationVRSNDEEKYGFIPKV
CCCCCHHHHCCCCEE		48.9324961812
278PhosphorylationIPKVFVRSRRSSFAY
CCEEEEECCCCCCCC		27.0921440633
281PhosphorylationVFVRSRRSSFAYPQQ
EEEECCCCCCCCCCE		28.7922890988
282PhosphorylationFVRSRRSSFAYPQQV
EEECCCCCCCCCCEE		16.4617330950
285PhosphorylationSRRSSFAYPQQVAIT
CCCCCCCCCCEEEEE		10.2822890988
292PhosphorylationYPQQVAITTTPSSPN
CCCEEEEEECCCCCC		18.1922890988
293PhosphorylationPQQVAITTTPSSPNS
CCEEEEEECCCCCCC		30.5122890988
294PhosphorylationQQVAITTTPSSPNSS
CEEEEEECCCCCCCC		16.7222890988
296PhosphorylationVAITTTPSSPNSSHV
EEEEECCCCCCCCEE		57.2322369663
297PhosphorylationAITTTPSSPNSSHVL
EEEECCCCCCCCEEE		29.3322369663
300PhosphorylationTTPSSPNSSHVLLSS
ECCCCCCCCEEEECC		25.7922890988
301PhosphorylationTPSSPNSSHVLLSSK
CCCCCCCCEEEECCC		25.0222890988
306PhosphorylationNSSHVLLSSKSRRGS
CCCEEEECCCCCCCC		31.4022890988
307PhosphorylationSSHVLLSSKSRRGSL
CCEEEECCCCCCCCC		34.3222890988
308UbiquitinationSHVLLSSKSRRGSLA
CEEEECCCCCCCCCC		44.6024961812
309PhosphorylationHVLLSSKSRRGSLAN
EEEECCCCCCCCCCC		29.2024909858
313PhosphorylationSSKSRRGSLANWSRR
CCCCCCCCCCCCCCC		23.6121082442
318PhosphorylationRGSLANWSRRSSFNV
CCCCCCCCCCCCCCC		20.0224909858
321PhosphorylationLANWSRRSSFNVSSN
CCCCCCCCCCCCCCC		37.8722890988
322PhosphorylationANWSRRSSFNVSSNN
CCCCCCCCCCCCCCC		21.0122890988
326PhosphorylationRRSSFNVSSNNTSRR
CCCCCCCCCCCCCCC		28.5822890988
327PhosphorylationRSSFNVSSNNTSRRS
CCCCCCCCCCCCCCC		29.8022890988
330PhosphorylationFNVSSNNTSRRSSMI
CCCCCCCCCCCCEEE		28.0622890988
331PhosphorylationNVSSNNTSRRSSMIL
CCCCCCCCCCCEEEE		28.0222890988
334PhosphorylationSNNTSRRSSMILAPN
CCCCCCCCEEEECCC		24.1323749301
335PhosphorylationNNTSRRSSMILAPNS
CCCCCCCEEEECCCC		14.1823749301
342PhosphorylationSMILAPNSVSNIFNV
EEEECCCCCCCCEEE		26.3428889911
344PhosphorylationILAPNSVSNIFNVNN
EECCCCCCCCEEECC		24.8319779198
352PhosphorylationNIFNVNNSGSNTAST
CCEEECCCCCCCCCC		38.0923749301
354PhosphorylationFNVNNSGSNTASTSN
EEECCCCCCCCCCCC		30.7223749301
356PhosphorylationVNNSGSNTASTSNTN
ECCCCCCCCCCCCCC		24.5528889911
358PhosphorylationNSGSNTASTSNTNSR
CCCCCCCCCCCCCHH		30.2628889911
359PhosphorylationSGSNTASTSNTNSRR
CCCCCCCCCCCCHHH		24.4323749301
360PhosphorylationGSNTASTSNTNSRRE
CCCCCCCCCCCHHHH		38.8823749301
362PhosphorylationNTASTSNTNSRRESV
CCCCCCCCCHHHHHH		34.0523749301
364PhosphorylationASTSNTNSRRESVIK
CCCCCCCHHHHHHHH		30.5823749301
368PhosphorylationNTNSRRESVIKKEFQ
CCCHHHHHHHHHHHH		27.6028132839
398PhosphorylationNGPIFPNSYTFMDLP
CCCCCCCCEEEEECC		26.2823749301
400PhosphorylationPIFPNSYTFMDLPHS
CCCCCCEEEEECCCC		16.5923749301
407PhosphorylationTFMDLPHSSSVSSSS
EEEECCCCCCCCCCC		23.5123749301
408PhosphorylationFMDLPHSSSVSSSST
EEECCCCCCCCCCCC		31.5523749301
409PhosphorylationMDLPHSSSVSSSSTL
EECCCCCCCCCCCCC		29.0923749301
411PhosphorylationLPHSSSVSSSSTLHK
CCCCCCCCCCCCCCC		26.8423749301
412PhosphorylationPHSSSVSSSSTLHKS
CCCCCCCCCCCCCCC		26.5923749301
413PhosphorylationHSSSVSSSSTLHKSK
CCCCCCCCCCCCCCC		21.6023749301
419PhosphorylationSSSTLHKSKRGSFSG
CCCCCCCCCCCCCCC		19.4823749301
423PhosphorylationLHKSKRGSFSGHSMK
CCCCCCCCCCCCCCC		21.9219823750
425PhosphorylationKSKRGSFSGHSMKSS
CCCCCCCCCCCCCCC		36.9822890988
428PhosphorylationRGSFSGHSMKSSCNP
CCCCCCCCCCCCCCC		31.2822890988
456PhosphorylationENKKRNLSVMELSIL
HHHHCCEEEEEEEEE		23.9824909858
480PhosphorylationQWRLNALSSDADMLS
HHHHHHHCCCCCCCC		24.6222890988
481PhosphorylationWRLNALSSDADMLSP
HHHHHHCCCCCCCCC		37.3522369663
487PhosphorylationSSDADMLSPTHSPQK
CCCCCCCCCCCCCCC		22.5522369663
489PhosphorylationDADMLSPTHSPQKTL
CCCCCCCCCCCCCCC		31.4522369663
491PhosphorylationDMLSPTHSPQKTLSK
CCCCCCCCCCCCCCC		31.3522369663
495PhosphorylationPTHSPQKTLSKKTCP
CCCCCCCCCCCCCCC		30.8923749301
497PhosphorylationHSPQKTLSKKTCPRM
CCCCCCCCCCCCCCC		37.0221440633
507PhosphorylationTCPRMFKSGSTTDDD
CCCCCCCCCCCCCCC		27.0628889911
509PhosphorylationPRMFKSGSTTDDDKG
CCCCCCCCCCCCCCC		34.9128889911
510PhosphorylationRMFKSGSTTDDDKGS
CCCCCCCCCCCCCCC		37.4620377248
511PhosphorylationMFKSGSTTDDDKGSD
CCCCCCCCCCCCCCC		38.8420377248
517PhosphorylationTTDDDKGSDKEDVMG
CCCCCCCCCHHHHCC		51.7721551504
527PhosphorylationEDVMGDGSNDDDEDN
HHHCCCCCCCCCCCC		41.6521551504
548PhosphorylationAKQSSNKTVFSSSSS
HHHHCCCEEECCCCC		30.9122369663
551PhosphorylationSSNKTVFSSSSSNIS
HCCCEEECCCCCCCC		25.6022369663
552PhosphorylationSNKTVFSSSSSNISS
CCCEEECCCCCCCCC		23.8322369663
553PhosphorylationNKTVFSSSSSNISSK
CCEEECCCCCCCCCC		36.2722369663
554PhosphorylationKTVFSSSSSNISSKD
CEEECCCCCCCCCCC		29.3822369663
555PhosphorylationTVFSSSSSNISSKDV
EEECCCCCCCCCCCC		39.8822369663
558PhosphorylationSSSSSNISSKDVSPD
CCCCCCCCCCCCCCC		35.2722369663
559PhosphorylationSSSSNISSKDVSPDP
CCCCCCCCCCCCCCC		29.1322369663
563PhosphorylationNISSKDVSPDPIFSP
CCCCCCCCCCCCCCC		33.4522369663
569PhosphorylationVSPDPIFSPDPADDS
CCCCCCCCCCCCCCC		29.1622890988
576PhosphorylationSPDPADDSSNTSDAG
CCCCCCCCCCCCCCC		26.4921440633
577PhosphorylationPDPADDSSNTSDAGS
CCCCCCCCCCCCCCC		51.6422890988
579PhosphorylationPADDSSNTSDAGSRC
CCCCCCCCCCCCCCE		29.9022890988
580PhosphorylationADDSSNTSDAGSRCT
CCCCCCCCCCCCCEE		29.7022890988
584PhosphorylationSNTSDAGSRCTITSD
CCCCCCCCCEEEEEC		26.3822890988
589PhosphorylationAGSRCTITSDTSSSA
CCCCEEEEECCCCCC		11.4620377248
590PhosphorylationGSRCTITSDTSSSAA
CCCEEEEECCCCCCC		34.7323749301
592PhosphorylationRCTITSDTSSSAATM
CEEEEECCCCCCCCC		30.2123749301
593PhosphorylationCTITSDTSSSAATMN
EEEEECCCCCCCCCC		27.5623749301
594PhosphorylationTITSDTSSSAATMNR
EEEECCCCCCCCCCC		26.5323749301
598PhosphorylationDTSSSAATMNRTPNS
CCCCCCCCCCCCCCC		18.0723749301
602PhosphorylationSAATMNRTPNSKNPQ
CCCCCCCCCCCCCHH		23.0923749301
605PhosphorylationTMNRTPNSKNPQDIA
CCCCCCCCCCHHHHH		34.7121082442
606AcetylationMNRTPNSKNPQDIAL
CCCCCCCCCHHHHHH		78.3322865919
606UbiquitinationMNRTPNSKNPQDIAL
CCCCCCCCCHHHHHH		78.3323749301
623PhosphorylationNFRSEAITPRPKPSS
CCCCCCCCCCCCCCC		21.9421440633
637PhosphorylationSTTTSITTETTNNMI
CCEEEEEEECCCCCC		29.6621551504
657PhosphorylationTTTTTNNSPLPSINT
CCCCCCCCCCCCHHH		29.8621551504
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DOT6_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DOT6_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DOT6_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NST1_YEASTNST1physical
16554755
MUM2_YEASTMUM2genetic
17314980
ARO1_YEASTARO1genetic
17314980
PCNA_YEASTPOL30genetic
17314980
RTG3_YEASTRTG3genetic
17314980
SSB1_YEASTSSB1physical
19536198
KAPA_YEASTTPK1physical
16751660
RLA1_YEASTRPP1Agenetic
20093466
PKH3_YEASTPKH3genetic
20093466
DCOR_YEASTSPE1genetic
20093466
ROM2_YEASTROM2genetic
20093466
GGPPS_YEASTBTS1genetic
20093466
CHL1_YEASTCHL1genetic
20093466
IXR1_YEASTIXR1genetic
20959818
AATC_YEASTAAT2genetic
20959818
SPT8_YEASTSPT8genetic
20959818
SGF73_YEASTSGF73genetic
20959818
JHD1_YEASTJHD1genetic
21127252
RPN4_YEASTRPN4genetic
21127252
SDS3_YEASTSDS3genetic
21730963
RPD3_YEASTRPD3genetic
21730963
SDS3_YEASTSDS3physical
21730963
PKH3_YEASTPKH3genetic
22282571
REG2_YEASTREG2genetic
27708008
IMG2_YEASTIMG2genetic
27708008
SNF6_YEASTSNF6genetic
27708008
AIR1_YEASTAIR1genetic
27708008
LST4_YEASTLST4genetic
27708008
DCOR_YEASTSPE1genetic
27708008
ROM2_YEASTROM2genetic
27708008
CHL1_YEASTCHL1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DOT6_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481; SER-491; SER-553;SER-555 AND SER-558, AND MASS SPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-247, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-491, AND MASSSPECTROMETRY.

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