| UniProt ID | ROM2_YEAST | |
|---|---|---|
| UniProt AC | P51862 | |
| Protein Name | RHO1 GDP-GTP exchange protein 2 | |
| Gene Name | ROM2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1356 | |
| Subcellular Localization | ||
| Protein Description | Stimulates the exchange of RHO1 GDP-bound form into GTP-bound form.. | |
| Protein Sequence | MSETNVDSLGDRNDIYSQIFGVERRPDSFATFDSDSHGDISSQLLPNRIENIQNLNVLLSEDIANDIIIAKQRRRSGVEAAIDDSDIPNNEMKGKSSNYILSQQTNIKEVPDTQSLSSADNTPVSSPKKARDATSSHPIVHAKSMSHIYSTSNSASRQAKHYNDHPLPPMSPRNEVYQKNKSTTAFVPKRKPSLPQLALAGLKKQSSFSTGSASTTPTQARKSPLQGFGFFSRPSSKDLHEQHQHHQHIQHNNINNHNNNNTNNNGAHYQVGSSNSNYPQHSHSISSRSMSLNSSTLKNIASSFQSKTSNSRKATQKYDITSNPFSDPHHHHHHHHSSNSHSSLNNVHGSGNSSSVMGSSSNIGLGLKTRVSSTSLALKRYTSVSGTSLSSPRRSSMTPLSASRPVMSASSKKPQVYPALLSRVATKFKSSIQLGEHKKDGLVYRDAFTGQQAVDVICAIIRTSDRNLALLFGRSLDAQKLFHDVVYEHRLRDSPHEVYEFTDNSRFTGTGSTNAHDPLMLLPNSSSFNSGNHSYPNSGMVPSSSTSSLNSDQATLTGSRLHMSSSLSQQKNPAAIHNVNGVFTLLAECYSPTCTRDALCYSISCPRRLEQQARLNLKPNGGLKRNISMALDDDDEEKPSWTSSVSKEDWENLPKKEIKRQEAIYEVYITEKNFVKSLEITRDTFMKTLAETNIISADIRKNFIKHVFAHINDIYSVNRRFLKALTDRQRSSPVVRGIGDIVLRFIPFFEPFVSYVASRPYAKYLIETQRSVNPYFARFDDDMMSSSLRHGIDSFLSQGVSRPGRYMLLVKEIMKSTDPEKDKSDYEDLSKAMDALRDFMKRIDQASGAAQDRHDVKLLKQKILFKNEYVNLGLNDERRKIKHEGILSRKELSKSDGTVVGDIQFYLLDNMLLFLKAKAVNKWHQHKVFQRPIPLPLLFACPGEDMPALRKYIGDHPDCSGTVIQPEYNTSNPKNAITFLYYGAKQRYQVTLYAAQYAGLQTLLEKIKQGQAAIISKTEMFNVTKMSDRFFDYTNKINSVTSCDGGRKLLIATNSGLYMSNIKRQQNKDHRHKSSAFFSTPIQLVQRNNITQIAVLEEFKSIILLIDKKLYSCPLSLIEAEGNGTSFFKKHHKELINHVSFFAEGDCNGKRLIVTAHSSSHSIKYFEHEHPLLAEKNGSGSGNKKSLKKKITEVIFDSEPVSISFLKANLCIGCKKGFQIVSISQNAHESLLDPADTSLEFALRDTLKPMAIYRVGNMFLLCYTEFAFFVNNQGWRKKESHIIHWEGEPQKFAIWYPYILAFDSNFIEIRKIETGELIRCVLADKIRLLQTSTQEILYCYEDYRGYDTVASLDFWG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSETNVDSL ------CCCCCCCCC | 65.51 | 22814378 | |
| 76 | Phosphorylation | IAKQRRRSGVEAAID EEHHHHHCCCCCCCC | 45.43 | 22369663 | |
| 85 | Phosphorylation | VEAAIDDSDIPNNEM CCCCCCCCCCCCCCC | 33.42 | 29688323 | |
| 96 | Phosphorylation | NNEMKGKSSNYILSQ CCCCCCCCHHCEECC | 32.27 | 27017623 | |
| 97 | Phosphorylation | NEMKGKSSNYILSQQ CCCCCCCHHCEECCC | 36.82 | 21440633 | |
| 108 | Ubiquitination | LSQQTNIKEVPDTQS ECCCCCCCCCCCCCC | 55.52 | 17644757 | |
| 113 | Phosphorylation | NIKEVPDTQSLSSAD CCCCCCCCCCCCCCC | 17.62 | 28889911 | |
| 115 | Phosphorylation | KEVPDTQSLSSADNT CCCCCCCCCCCCCCC | 32.10 | 20377248 | |
| 117 | Phosphorylation | VPDTQSLSSADNTPV CCCCCCCCCCCCCCC | 28.82 | 20377248 | |
| 118 | Phosphorylation | PDTQSLSSADNTPVS CCCCCCCCCCCCCCC | 44.96 | 20377248 | |
| 122 | Phosphorylation | SLSSADNTPVSSPKK CCCCCCCCCCCCCCH | 26.14 | 20377248 | |
| 125 | Phosphorylation | SADNTPVSSPKKARD CCCCCCCCCCCHHCC | 41.97 | 21551504 | |
| 126 | Phosphorylation | ADNTPVSSPKKARDA CCCCCCCCCCHHCCC | 40.76 | 21440633 | |
| 128 | Ubiquitination | NTPVSSPKKARDATS CCCCCCCCHHCCCCC | 62.10 | 17644757 | |
| 129 | Ubiquitination | TPVSSPKKARDATSS CCCCCCCHHCCCCCC | 52.63 | 17644757 | |
| 135 | Phosphorylation | KKARDATSSHPIVHA CHHCCCCCCCCEEEH | 28.50 | 30377154 | |
| 143 | Ubiquitination | SHPIVHAKSMSHIYS CCCEEEHHHHHHEEE | 31.64 | 17644757 | |
| 144 | Phosphorylation | HPIVHAKSMSHIYST CCEEEHHHHHHEEEC | 26.71 | 22369663 | |
| 146 | Phosphorylation | IVHAKSMSHIYSTSN EEEHHHHHHEEECCC | 17.52 | 22369663 | |
| 149 | Phosphorylation | AKSMSHIYSTSNSAS HHHHHHEEECCCHHH | 10.65 | 22369663 | |
| 150 | Phosphorylation | KSMSHIYSTSNSASR HHHHHEEECCCHHHC | 25.42 | 21440633 | |
| 151 | Phosphorylation | SMSHIYSTSNSASRQ HHHHEEECCCHHHCH | 18.24 | 22369663 | |
| 152 | Phosphorylation | MSHIYSTSNSASRQA HHHEEECCCHHHCHH | 23.89 | 22369663 | |
| 154 | Phosphorylation | HIYSTSNSASRQAKH HEEECCCHHHCHHHH | 27.65 | 19823750 | |
| 156 | Phosphorylation | YSTSNSASRQAKHYN EECCCHHHCHHHHCC | 25.42 | 19823750 | |
| 171 | Phosphorylation | DHPLPPMSPRNEVYQ CCCCCCCCCCCHHHC | 26.87 | 21440633 | |
| 177 | Phosphorylation | MSPRNEVYQKNKSTT CCCCCHHHCCCCCCC | 13.95 | 24961812 | |
| 182 | Phosphorylation | EVYQKNKSTTAFVPK HHHCCCCCCCCCCCC | 40.14 | 22369663 | |
| 183 | Phosphorylation | VYQKNKSTTAFVPKR HHCCCCCCCCCCCCC | 24.61 | 22369663 | |
| 184 | Phosphorylation | YQKNKSTTAFVPKRK HCCCCCCCCCCCCCC | 25.78 | 22369663 | |
| 193 | Phosphorylation | FVPKRKPSLPQLALA CCCCCCCCHHHHHHH | 56.57 | 22369663 | |
| 203 | Ubiquitination | QLALAGLKKQSSFST HHHHHCHHCCCCCCC | 48.09 | 17644757 | |
| 204 | Ubiquitination | LALAGLKKQSSFSTG HHHHCHHCCCCCCCC | 61.53 | 17644757 | |
| 206 | Phosphorylation | LAGLKKQSSFSTGSA HHCHHCCCCCCCCCC | 42.08 | 20377248 | |
| 207 | Phosphorylation | AGLKKQSSFSTGSAS HCHHCCCCCCCCCCC | 22.26 | 22369663 | |
| 209 | Phosphorylation | LKKQSSFSTGSASTT HHCCCCCCCCCCCCC | 33.53 | 22369663 | |
| 210 | Phosphorylation | KKQSSFSTGSASTTP HCCCCCCCCCCCCCC | 32.90 | 22369663 | |
| 212 | Phosphorylation | QSSFSTGSASTTPTQ CCCCCCCCCCCCCCC | 21.09 | 22369663 | |
| 214 | Phosphorylation | SFSTGSASTTPTQAR CCCCCCCCCCCCCCC | 34.21 | 22369663 | |
| 215 | Phosphorylation | FSTGSASTTPTQARK CCCCCCCCCCCCCCC | 36.19 | 21440633 | |
| 216 | Phosphorylation | STGSASTTPTQARKS CCCCCCCCCCCCCCC | 23.11 | 22369663 | |
| 218 | Phosphorylation | GSASTTPTQARKSPL CCCCCCCCCCCCCCC | 32.54 | 22369663 | |
| 222 | Ubiquitination | TTPTQARKSPLQGFG CCCCCCCCCCCCCCC | 60.48 | 17644757 | |
| 223 | Phosphorylation | TPTQARKSPLQGFGF CCCCCCCCCCCCCCC | 25.86 | 22369663 | |
| 232 | Phosphorylation | LQGFGFFSRPSSKDL CCCCCCCCCCCCCCH | 40.81 | 22369663 | |
| 235 | Phosphorylation | FGFFSRPSSKDLHEQ CCCCCCCCCCCHHHH | 49.24 | 22369663 | |
| 236 | Phosphorylation | GFFSRPSSKDLHEQH CCCCCCCCCCHHHHH | 32.64 | 20377248 | |
| 289 | Phosphorylation | SHSISSRSMSLNSST CCCCCCCCCCCCHHH | 18.05 | 22369663 | |
| 291 | Phosphorylation | SISSRSMSLNSSTLK CCCCCCCCCCHHHHH | 26.16 | 22369663 | |
| 294 | Phosphorylation | SRSMSLNSSTLKNIA CCCCCCCHHHHHHHH | 29.96 | 22369663 | |
| 295 | Phosphorylation | RSMSLNSSTLKNIAS CCCCCCHHHHHHHHH | 36.36 | 21440633 | |
| 302 | Phosphorylation | STLKNIASSFQSKTS HHHHHHHHHHHHCCC | 28.08 | 30377154 | |
| 303 | Phosphorylation | TLKNIASSFQSKTSN HHHHHHHHHHHCCCC | 20.48 | 21551504 | |
| 306 | Phosphorylation | NIASSFQSKTSNSRK HHHHHHHHCCCCCCC | 35.57 | 21551504 | |
| 369 | Phosphorylation | NIGLGLKTRVSSTSL CEECCCCCCCCCCEE | 41.15 | 22369663 | |
| 372 | Phosphorylation | LGLKTRVSSTSLALK CCCCCCCCCCEEEEE | 25.30 | 25521595 | |
| 373 | Phosphorylation | GLKTRVSSTSLALKR CCCCCCCCCEEEEEE | 21.11 | 20377248 | |
| 374 | Phosphorylation | LKTRVSSTSLALKRY CCCCCCCCEEEEEEE | 21.91 | 22369663 | |
| 375 | Phosphorylation | KTRVSSTSLALKRYT CCCCCCCEEEEEEEE | 17.37 | 22369663 | |
| 379 | Ubiquitination | SSTSLALKRYTSVSG CCCEEEEEEEECCCC | 37.44 | 17644757 | |
| 381 | Phosphorylation | TSLALKRYTSVSGTS CEEEEEEEECCCCCC | 11.20 | 22369663 | |
| 382 | Phosphorylation | SLALKRYTSVSGTSL EEEEEEEECCCCCCC | 27.04 | 22369663 | |
| 383 | Phosphorylation | LALKRYTSVSGTSLS EEEEEEECCCCCCCC | 12.83 | 22369663 | |
| 385 | Phosphorylation | LKRYTSVSGTSLSSP EEEEECCCCCCCCCC | 35.80 | 22369663 | |
| 387 | Phosphorylation | RYTSVSGTSLSSPRR EEECCCCCCCCCCCC | 20.98 | 22369663 | |
| 388 | Phosphorylation | YTSVSGTSLSSPRRS EECCCCCCCCCCCCC | 29.76 | 22369663 | |
| 390 | Phosphorylation | SVSGTSLSSPRRSSM CCCCCCCCCCCCCCC | 37.76 | 22369663 | |
| 391 | Phosphorylation | VSGTSLSSPRRSSMT CCCCCCCCCCCCCCC | 27.93 | 22369663 | |
| 396 | Phosphorylation | LSSPRRSSMTPLSAS CCCCCCCCCCCCCCC | 25.51 | 28889911 | |
| 398 | Phosphorylation | SPRRSSMTPLSASRP CCCCCCCCCCCCCCC | 24.03 | 21440633 | |
| 403 | Phosphorylation | SMTPLSASRPVMSAS CCCCCCCCCCCCCCC | 33.47 | 28889911 | |
| 408 | Phosphorylation | SASRPVMSASSKKPQ CCCCCCCCCCCCCCC | 25.82 | 22369663 | |
| 410 | Phosphorylation | SRPVMSASSKKPQVY CCCCCCCCCCCCCHH | 35.07 | 22369663 | |
| 411 | Phosphorylation | RPVMSASSKKPQVYP CCCCCCCCCCCCHHH | 44.40 | 22369663 | |
| 412 | Ubiquitination | PVMSASSKKPQVYPA CCCCCCCCCCCHHHH | 67.01 | 17644757 | |
| 413 | Ubiquitination | VMSASSKKPQVYPAL CCCCCCCCCCHHHHH | 42.50 | 17644757 | |
| 429 | Ubiquitination | SRVATKFKSSIQLGE HHHHHHHHHHHCCCC | 44.86 | 17644757 | |
| 438 | Ubiquitination | SIQLGEHKKDGLVYR HHCCCCCCCCCEEEE | 48.54 | 17644757 | |
| 439 | Ubiquitination | IQLGEHKKDGLVYRD HCCCCCCCCCEEEEC | 59.96 | 17644757 | |
| 480 | Ubiquitination | GRSLDAQKLFHDVVY CCCCCHHHHHHHHHH | 55.64 | 17644757 | |
| 494 | Phosphorylation | YEHRLRDSPHEVYEF HHHCCCCCCCCEEEC | 23.02 | 28889911 | |
| 564 | Phosphorylation | TGSRLHMSSSLSQQK CCCCEECCCCCCCCC | 13.16 | 22369663 | |
| 565 | Phosphorylation | GSRLHMSSSLSQQKN CCCEECCCCCCCCCC | 27.94 | 22369663 | |
| 566 | Phosphorylation | SRLHMSSSLSQQKNP CCEECCCCCCCCCCH | 25.41 | 22369663 | |
| 568 | Phosphorylation | LHMSSSLSQQKNPAA EECCCCCCCCCCHHH | 32.29 | 22369663 | |
| 571 | Ubiquitination | SSSLSQQKNPAAIHN CCCCCCCCCHHHHHC | 58.21 | 17644757 | |
| 628 | Phosphorylation | GGLKRNISMALDDDD CCCCCCEEEECCCCC | 11.10 | 25521595 | |
| 640 | Phosphorylation | DDDEEKPSWTSSVSK CCCCCCCCCCCCCCH | 54.79 | 19779198 | |
| 659 | Ubiquitination | NLPKKEIKRQEAIYE HCCHHHHHHHHHEEE | 49.47 | 17644757 | |
| 672 | Ubiquitination | YEVYITEKNFVKSLE EEEEEECCCHHHEEE | 47.22 | 17644757 | |
| 857 | Acetylation | AQDRHDVKLLKQKIL CCCHHHHHHHHEEEH | 54.91 | 25381059 | |
| 1073 | Ubiquitination | QNKDHRHKSSAFFST CCCCCCCCHHHHHCC | 46.17 | 17644757 | |
| 1080 | Phosphorylation | KSSAFFSTPIQLVQR CHHHHHCCHHHHHHC | 21.18 | 28889911 | |
| 1091 | Phosphorylation | LVQRNNITQIAVLEE HHHCCCCCEEEHHHH | 18.95 | 28889911 | |
| 1140 | Phosphorylation | KELINHVSFFAEGDC HHHHHHHHEEECCCC | 13.70 | 21551504 | |
| 1158 | Phosphorylation | RLIVTAHSSSHSIKY EEEEEEECCCCCCCE | 30.95 | 21551504 | |
| 1159 | Phosphorylation | LIVTAHSSSHSIKYF EEEEEECCCCCCCEE | 23.39 | 21551504 | |
| 1189 | Ubiquitination | GNKKSLKKKITEVIF CCHHHHHHHHEEEEC | 55.49 | 17644757 | |
| 1190 | Ubiquitination | NKKSLKKKITEVIFD CHHHHHHHHEEEECC | 53.96 | 17644757 | |
| 1207 | Ubiquitination | PVSISFLKANLCIGC CEEHHHEECCEECCC | 32.97 | 17644757 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ROM2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ROM2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ROM2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76; SER-117; SER-118;SER-207; THR-387; SER-388; SER-568 AND THR-1091, AND MASSSPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76; SER-193 AND SER-223,AND MASS SPECTROMETRY. | |
| "A proteomics approach to understanding protein ubiquitination."; Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.; Nat. Biotechnol. 21:921-926(2003). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193 AND SER-385, ANDMASS SPECTROMETRY. | |
