WSC2_YEAST - dbPTM
WSC2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID WSC2_YEAST
UniProt AC P53832
Protein Name Cell wall integrity and stress response component 2
Gene Name WSC2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 503
Subcellular Localization Cell membrane
Single-pass membrane protein.
Protein Description
Protein Sequence MHLDLIHKSFILVWLIYIRAALADQFTYKACYSASDIRKLGLTYKGVYEYQSVSYCQNECPGQAVVALFNGTGCYCGGSVAQLQSLTQVDSSKCDVSCAGWPYQNCGGSSAMNVYINNAASTADSTSSTATSTSTTSSSSTSVSSKTSTKLDTKTSTSSSATHSSSSSSTTSTTTSSSETTTSSSSSSSSSSTSTTSTTSTTSSTTSTSSSPSTTSSSTSASSSSETSSTQATSSSTTSTSSSTSTATVTSTPSSTSIGTSTHYTTRVVTQSVVSQANQQASTIFTTRTSVYATVSSTSSSTSSLLNGKSSSSKSKGLSGGAIAGVVVGVVCGTVALLALALFFFVWKKRRQSSQHVDLEETKQYQPYSLGDADANPVIPPSASSTNWHIPSRNNTALSKNTASTFATYDLPTRAPGGRDSIITGDAHNISKRSHFPSVVYEEPPSIYNGNQRFSATSLPDMMEERQLHIVNPDNVSSNIGSNVSDGDDDYDDAKDSNNSSLR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
272PhosphorylationTTRVVTQSVVSQANQ
EEEEEEHHHHHHHHH		18.3430377154
303PhosphorylationSSTSSSTSSLLNGKS
ECCCCCCCHHHCCCC		22.4219779198
304PhosphorylationSTSSSTSSLLNGKSS
CCCCCCCHHHCCCCC		36.6419779198
382PhosphorylationANPVIPPSASSTNWH
CCCCCCCCCCCCCCC		35.1121440633
384PhosphorylationPVIPPSASSTNWHIP
CCCCCCCCCCCCCCC		41.8723749301
392PhosphorylationSTNWHIPSRNNTALS
CCCCCCCCCCCCCCC		47.2221440633
400UbiquitinationRNNTALSKNTASTFA
CCCCCCCCCCCCCEE		60.2023749301
402PhosphorylationNTALSKNTASTFATY
CCCCCCCCCCCEEEE		26.2228889911
405PhosphorylationLSKNTASTFATYDLP
CCCCCCCCEEEEECC		18.1521440633
409PhosphorylationTASTFATYDLPTRAP
CCCCEEEEECCCCCC		16.4421440633
421PhosphorylationRAPGGRDSIITGDAH
CCCCCCCCCCCCCCC		17.9621440633
424PhosphorylationGGRDSIITGDAHNIS
CCCCCCCCCCCCCCC		27.6028889911
431PhosphorylationTGDAHNISKRSHFPS
CCCCCCCCCCCCCCC		27.6021440633
438PhosphorylationSKRSHFPSVVYEEPP
CCCCCCCCEEECCCC		24.2219779198
441PhosphorylationSHFPSVVYEEPPSIY
CCCCCEEECCCCCCC		16.6619779198
446PhosphorylationVVYEEPPSIYNGNQR
EEECCCCCCCCCCCC		48.7121440633
448PhosphorylationYEEPPSIYNGNQRFS
ECCCCCCCCCCCCCC		22.7327017623
455PhosphorylationYNGNQRFSATSLPDM
CCCCCCCCCCCCCCH		32.5922369663
457PhosphorylationGNQRFSATSLPDMME
CCCCCCCCCCCCHHH		29.6022369663
458PhosphorylationNQRFSATSLPDMMEE
CCCCCCCCCCCHHHH		37.3122369663
462OxidationSATSLPDMMEERQLH
CCCCCCCHHHHCCEE		3.2515665377
463OxidationATSLPDMMEERQLHI
CCCCCCHHHHCCEEE		6.7115665377
477PhosphorylationIVNPDNVSSNIGSNV
ECCCCCCCCCCCCCC		24.7519795423
478PhosphorylationVNPDNVSSNIGSNVS
CCCCCCCCCCCCCCC		28.3419795423
482PhosphorylationNVSSNIGSNVSDGDD
CCCCCCCCCCCCCCC		30.2028132839
485PhosphorylationSNIGSNVSDGDDDYD
CCCCCCCCCCCCCCC		39.8828132839
491PhosphorylationVSDGDDDYDDAKDSN
CCCCCCCCCCCCCCC		23.7919795423
497PhosphorylationDYDDAKDSNNSSLR-
CCCCCCCCCCCCCC-		36.8919795423
500PhosphorylationDAKDSNNSSLR----
CCCCCCCCCCC----		34.6919795423
501PhosphorylationAKDSNNSSLR-----
CCCCCCCCCC-----		30.2219795423
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of WSC2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of WSC2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of WSC2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RHO1_YEASTRHO1genetic
9391108
RHO3_YEASTRHO3genetic
9391108
MID2_YEASTMID2genetic
10330137
WSC3_YEASTWSC3physical
18467557
WSC2_YEASTWSC2physical
18467557
PDR12_YEASTPDR12physical
18467557
KPC1_YEASTPKC1genetic
11554924
RAS2_YEASTRAS2genetic
11589572
BCK1_YEASTBCK1genetic
22747505
BPH1_YEASTBPH1genetic
23891562
HNT2_YEASTHNT2genetic
27708008
ERG3_YEASTERG3genetic
27708008
RU2A_YEASTLEA1genetic
27708008
RMRP_YEASTSNM1genetic
27708008
ACT_YEASTACT1genetic
27708008
RPC6_YEASTRPC34genetic
27708008
PROF_YEASTPFY1genetic
27708008
MDM10_YEASTMDM10genetic
27708008
GEM1_YEASTGEM1genetic
27708008
ECM15_YEASTECM15genetic
27708008
NU170_YEASTNUP170genetic
27708008
EDS1_YEASTEDS1genetic
27708008
SIF2_YEASTSIF2genetic
27708008
RMD9L_YEASTYBR238Cgenetic
27708008
SGF29_YEASTSGF29genetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
ARX1_YEASTARX1genetic
27708008
UME6_YEASTUME6genetic
27708008
GGA1_YEASTGGA1genetic
27708008
LSM6_YEASTLSM6genetic
27708008
SHE9_YEASTSHE9genetic
27708008
SLX8_YEASTSLX8genetic
27708008
PEA2_YEASTPEA2genetic
27708008
YEY6_YEASTYER156Cgenetic
27708008
BUD27_YEASTBUD27genetic
27708008
LSB3_YEASTLSB3genetic
27708008
CTU1_YEASTNCS6genetic
27708008
MDM34_YEASTMDM34genetic
27708008
RTG2_YEASTRTG2genetic
27708008
BUB1_YEASTBUB1genetic
27708008
SSF1_YEASTSSF1genetic
27708008
VPS53_YEASTVPS53genetic
27708008
NCA3_YEASTNCA3genetic
27708008
RPE_YEASTRPE1genetic
27708008
AIM25_YEASTAIM25genetic
27708008
IXR1_YEASTIXR1genetic
27708008
MDM35_YEASTMDM35genetic
27708008
YET1_YEASTYET1genetic
27708008
MRS4_YEASTMRS4genetic
27708008
CSF1_YEASTCSF1genetic
27708008
RL37A_YEASTRPL37Agenetic
27708008
UPS1_YEASTUPS1genetic
27708008
CDC73_YEASTCDC73genetic
27708008
FAR3_YEASTFAR3genetic
27708008
SCS7_YEASTSCS7genetic
27708008
MKS1_YEASTMKS1genetic
27708008
PFD4_YEASTGIM3genetic
27708008
BRE5_YEASTBRE5genetic
27708008
SIN3_YEASTSIN3genetic
27708008
NOP12_YEASTNOP12genetic
27708008
MET22_YEASTMET22genetic
27708008
RTG1_YEASTRTG1genetic
27708008
ARF3_YEASTARF3genetic
27708008
SFL1_YEASTSFL1genetic
27708008
MRS2_YEASTMRS2genetic
27708008
LGE1_YEASTLGE1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
BEM4_YEASTBEM4genetic
27708008
YP162_YEASTYPL162Cgenetic
27708008
NCBP2_YEASTCBC2genetic
27708008
YME1_YEASTYME1genetic
27708008
BRR1_YEASTBRR1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of WSC2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-455 AND SER-458, ANDMASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-455 AND SER-458, ANDMASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-458, AND MASSSPECTROMETRY.

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