| UniProt ID | IXR1_YEAST | |
|---|---|---|
| UniProt AC | P33417 | |
| Protein Name | Intrastrand cross-link recognition protein | |
| Gene Name | IXR1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 597 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Binds to platinated DNA and confers sensitivity to the anticancer drug cisplatin. Activate the expression of the COX5B gene.. | |
| Protein Sequence | MNTGISPKQDDASNSNLLNIGQDHSLQYQGLEHNDSQYRDASHQTPHQYLNQFQAQPQQQQQQQQQQQQQQQQAPYQGHFQQSPQQQQQNVYYPLPPQSLTQPTSQSQQQQQQQQQQQYANSNSNSNNNVNVNALPQDFGYMQQTGSGQNYPTINQQQFSEFYNSFLSHLTQKQTNPSVTGTGASSNNNSNNNNVSSGNNSTSSNPAQLAASQLNPATAAAAAANNAAGPASYLSQLPQVQRYYPNNMNALSSLLDPSSAGNAAGNANTATHPGLLPPNLQPQLTHHQQQMQQQLQLQQQQQLQQQQQLQQQHQLQQQQQLQQQHHHLQQQQQQQQHPVVKKLSSTQSRIERRKQLKKQGPKRPSSAYFLFSMSIRNELLQQFPEAKVPELSKLASARWKELTDDQKKPFYEEFRTNWEKYRVVRDAYEKTLPPKRPSGPFIQFTQEIRPTVVKENPDKGLIEITKIIGERWRELDPAKKAEYTETYKKRLKEWESCYPDENDPNGNPTGHSHKAMNMNLNMDTKIMENQDSIEHITANAIDSVTGSNSNSTNPNTPVSPPISLQQQPLQQQQQQQQQQQHMLLADPTTNGSIIKNE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MNTGISPKQD -----CCCCCCCCCC | 34.30 | 22369663 | |
| 6 | Phosphorylation | --MNTGISPKQDDAS --CCCCCCCCCCCCC | 27.65 | 22369663 | |
| 13 | Phosphorylation | SPKQDDASNSNLLNI CCCCCCCCCCCCCCC | 48.03 | 22369663 | |
| 15 | Phosphorylation | KQDDASNSNLLNIGQ CCCCCCCCCCCCCCC | 26.76 | 22369663 | |
| 25 | Phosphorylation | LNIGQDHSLQYQGLE CCCCCCCCCCCCCCC | 26.00 | 22369663 | |
| 28 | Phosphorylation | GQDHSLQYQGLEHND CCCCCCCCCCCCCCC | 15.16 | 22369663 | |
| 36 | Phosphorylation | QGLEHNDSQYRDASH CCCCCCCHHHHCCCC | 34.13 | 22369663 | |
| 38 | Phosphorylation | LEHNDSQYRDASHQT CCCCCHHHHCCCCCC | 17.89 | 22369663 | |
| 344 | Phosphorylation | HPVVKKLSSTQSRIE CHHHHHHHHHHHHHH | 39.97 | 30377154 | |
| 348 | Phosphorylation | KKLSSTQSRIERRKQ HHHHHHHHHHHHHHH | 35.00 | 30377154 | |
| 387 | Acetylation | LQQFPEAKVPELSKL HHHCCCCCCHHHHHH | 57.57 | 24489116 | |
| 393 | Acetylation | AKVPELSKLASARWK CCCHHHHHHHHHHHH | 61.78 | 24489116 | |
| 459 | Acetylation | VVKENPDKGLIEITK ECCCCCCCCCEEHHH | 57.80 | 24489116 | |
| 466 | Acetylation | KGLIEITKIIGERWR CCCEEHHHHHHHHHH | 37.68 | 24489116 | |
| 532 | Phosphorylation | KIMENQDSIEHITAN HHHCCCHHHHHHHHH | 21.80 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IXR1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IXR1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IXR1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-532, AND MASSSPECTROMETRY. | |
