PTP1_YEAST - dbPTM
PTP1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PTP1_YEAST
UniProt AC P25044
Protein Name Tyrosine-protein phosphatase 1
Gene Name PTP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 335
Subcellular Localization Cytoplasm.
Protein Description Is not required for vegetative growth..
Protein Sequence MAAAPWYIRQRDTDLLGKFKFIQNQEDGRLREATNGTVNSRWSLGVSIEPRNDARNRYVNIMPYERNRVHLKTLSGNDYINASYVKVNVPGQSIEPGYYIATQGPTRKTWDQFWQMCYHNCPLDNIVIVMVTPLVEYNREKCYQYWPRGGVDDTVRIASKWESPGGANDMTQFPSDLKIEFVNVHKVKDYYTVTDIKLTPTDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNSRGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNITERSRHSDRATEEYTRDLIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKYLNSLSVNQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
20AcetylationTDLLGKFKFIQNQED
CCHHHCEEEEECCCC		45.0724489116
83PhosphorylationGNDYINASYVKVNVP
CCCCCCCEEEEEECC		26.4328889911
141AcetylationLVEYNREKCYQYWPR
CEEECHHHHHHHCCC		34.7024489116
310UbiquitinationQLRSQRMKMVQTKDQ
HHHHCCCCCCCCHHH		37.8023749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
83SPhosphorylationKinaseCLK1P38623
Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
83SPhosphorylation

10480872
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PTP1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FKBP3_YEASTFPR3physical
7559654
RAS2_YEASTRAS2genetic
19269370
SLA1_YEASTSLA1genetic
20093466
ELO2_YEASTELO2genetic
20093466
AIM7_YEASTAIM7genetic
20093466
VPS41_YEASTVPS41genetic
20093466
SAC3_YEASTSAC3genetic
20093466
HMO1_YEASTHMO1genetic
20093466
YEV1_YEASTYER121Wgenetic
20093466
YFF2_YEASTYFL052Wgenetic
20093466
RPOM_YEASTRPO41genetic
20093466
WWM1_YEASTWWM1genetic
20093466
BLM10_YEASTBLM10genetic
20093466
RME1_YEASTRME1genetic
20093466
MUP1_YEASTMUP1genetic
20093466
SKN1_YEASTSKN1genetic
20093466
YG5Q_YEASTYGR273Cgenetic
20093466
SODM_YEASTSOD2genetic
20093466
IRE1_YEASTIRE1genetic
20093466
THIK_YEASTPOT1genetic
20093466
ATG32_YEASTATG32genetic
20093466
MDM35_YEASTMDM35genetic
20093466
YK58_YEASTYKR078Wgenetic
20093466
PFD6_YEASTYKE2genetic
20093466
HXT2_YEASTHXT2genetic
20093466
SOK2_YEASTSOK2genetic
20093466
YMW4_YEASTYMR074Cgenetic
20093466
PFKA2_YEASTPFK2genetic
20093466
NGL2_YEASTNGL2genetic
20093466
ELP6_YEASTELP6genetic
20093466
OCA1_YEASTOCA1genetic
20093466
PHO23_YEASTPHO23genetic
20093466
NST1_YEASTNST1genetic
20093466
ATG3_YEASTATG3genetic
20093466
TRM11_YEASTTRM11genetic
20093466
MSN1_YEASTMSN1genetic
20093466
MSB4_YEASTMSB4genetic
20093466
YO075_YEASTYOL075Cgenetic
20093466
WTM2_YEASTWTM2genetic
20093466
WDR6_YEASTRTT10genetic
20093466
MDM36_YEASTMDM36genetic
20093466
YP089_YEASTYPR089Wgenetic
20093466
ATG13_YEASTATG13genetic
20093466
CDC14_YEASTCDC14physical
20489023
FKS1_YEASTFKS1physical
20489023
FKS2_YEASTGSC2physical
20489023
NOP12_YEASTNOP12physical
20489023
RIF1_YEASTRIF1physical
20489023
YE12B_YEASTYER160Cphysical
20489023
KSS1_YEASTKSS1physical
21460040
TBS1_YEASTTBS1genetic
21127252
RS27B_YEASTRPS27Bgenetic
27708008
NCA3_YEASTNCA3genetic
27708008
PEX15_YEASTPEX15genetic
27708008
MED1_YEASTMED1genetic
27708008
SLA1_YEASTSLA1genetic
27708008
CCZ1_YEASTCCZ1genetic
27708008
ELO2_YEASTELO2genetic
27708008
CSM1_YEASTCSM1genetic
27708008
VPS41_YEASTVPS41genetic
27708008
SAC3_YEASTSAC3genetic
27708008
BL1S4_YEASTCNL1genetic
27708008
RS26B_YEASTRPS26Bgenetic
27708008
BEM2_YEASTBEM2genetic
27708008
WWM1_YEASTWWM1genetic
27708008
VAM7_YEASTVAM7genetic
27708008
RME1_YEASTRME1genetic
27708008
MUP1_YEASTMUP1genetic
27708008
VMA21_YEASTVMA21genetic
27708008
ATG32_YEASTATG32genetic
27708008
THIK_YEASTPOT1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
YK58_YEASTYKR078Wgenetic
27708008
PFD6_YEASTYKE2genetic
27708008
YPT7_YEASTYPT7genetic
27708008
SOK2_YEASTSOK2genetic
27708008
IDH1_YEASTIDH1genetic
27708008
NST1_YEASTNST1genetic
27708008
ATG3_YEASTATG3genetic
27708008
MSN1_YEASTMSN1genetic
27708008
TRM11_YEASTTRM11genetic
27708008
CIN1_YEASTCIN1genetic
27708008
FUS3_YEASTFUS3physical
25736922
CN093_HUMANC14orf93physical
27107014
CDK1_YEASTCDC28physical
26715668
RV161_YEASTRVS161genetic
29674565
SCS2_YEASTSCS2genetic
29674565
GPI10_YEASTGPI10genetic
29674565
CHO2_YEASTCHO2genetic
29674565
ORC6_YEASTORC6genetic
29674565
APQ12_YEASTAPQ12genetic
29674565
ICE2_YEASTICE2genetic
29674565
STS1_YEASTSTS1genetic
29674565
RPC9_YEASTRPC17genetic
29674565
RFC2_YEASTRFC2genetic
29674565
DBP9_YEASTDBP9genetic
29674565
SCS7_YEASTSCS7genetic
29674565
NUF2_YEASTNUF2genetic
29674565
BUB3_YEASTBUB3genetic
29674565
OST2_YEASTOST2genetic
29674565
CHL1_YEASTCHL1genetic
29674565
ASA1_YEASTASA1genetic
29674565
RPC1_YEASTRPO31genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PTP1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The CLK family kinases, CLK1 and CLK2, phosphorylate and activate thetyrosine phosphatase, PTP-1B.";
Moeslein F.M., Myers M.P., Landreth G.E.;
J. Biol. Chem. 274:26697-26704(1999).
Cited for: PHOSPHORYLATION AT SER-83.

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