dbPTM

YE12B_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	YE12B_YEAST
UniProt AC	Q03619
Protein Name	Transposon Ty1-ER2 Gag-Pol polyprotein
Gene Name	TY1B-ER2
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	1755
Subcellular Localization	Cytoplasm. Nucleus.
Protein Description	Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)..
Protein Sequence	MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQKLTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYHSFIASNEIQQSNDLNIESDHDFQSDIELHPEQLRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISDIESTGSGGMHRLDVPLLAPMSQSNTHESSHASKSKDFRHSDSYSDNETNHTNVPISSTGGTNNKTVPQTSEQETEKRIIHRSPSIDTSSSESNSLHHVVPIKTSDTCPKENTEESIIADLPLPDLPPEPPTELSDSFKELPPINSHQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIQAYHKEVNQLLKMKTWDTDRYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDPGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQQELELEEDDYKMKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSKQVLDMTYELIQFIWNTRDKQLIWHKSKPVKPTNKLVVISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSHLVQELNKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCYIETKKNIADVMTKPLPIKTFKLLTNKWIH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MESQQLSN -------CCCCCCCC	46.79	-
13	Phosphorylation	LSNYPHISHGSACAS CCCCCCCCCCCCCCC	20.82	15665377
16	Phosphorylation	YPHISHGSACASVTS CCCCCCCCCCCCCCC	18.10	28889911
20	Phosphorylation	SHGSACASVTSKEVH CCCCCCCCCCCCCCC	26.30	28889911
22	Phosphorylation	GSACASVTSKEVHTN CCCCCCCCCCCCCCC	31.42	28889911
23	Phosphorylation	SACASVTSKEVHTNQ CCCCCCCCCCCCCCC	25.35	19823750
24	Ubiquitination	ACASVTSKEVHTNQD CCCCCCCCCCCCCCC	55.16	17644757
28	Phosphorylation	VTSKEVHTNQDPLDV CCCCCCCCCCCCCCC	39.49	28889911
36	Phosphorylation	NQDPLDVSASKIQEY CCCCCCCCHHHHHHH	26.88	25521595
38	Phosphorylation	DPLDVSASKIQEYDK CCCCCCHHHHHHHHH	23.84	25521595
39	Ubiquitination	PLDVSASKIQEYDKA CCCCCHHHHHHHHHH	48.39	24961812
43	Phosphorylation	SASKIQEYDKASTKA CHHHHHHHHHHCCCC	13.33	22890988
45	Ubiquitination	SKIQEYDKASTKANS HHHHHHHHHCCCCCC	43.25	15699485
47	Phosphorylation	IQEYDKASTKANSQQ HHHHHHHCCCCCCCC	35.86	25533186
48	Phosphorylation	QEYDKASTKANSQQT HHHHHHCCCCCCCCC	38.75	22890988
71	Phosphorylation	PENPHHASPQPASVP CCCCCCCCCCCCCCC	21.51	28889911
145	Phosphorylation	GTPLSTPSPESGNTF CCCCCCCCCCCCCCC	41.19	28889911
157	Phosphorylation	NTFTDSSSADSDMTS CCCCCCCCCCCCCCC	39.79	28889911
160	Phosphorylation	TDSSSADSDMTSTKK CCCCCCCCCCCCCCC	29.06	16445868
166	Ubiquitination	DSDMTSTKKYVRPPP CCCCCCCCCCCCCCC	41.70	15699485
167	Ubiquitination	SDMTSTKKYVRPPPM CCCCCCCCCCCCCCC	49.41	17644757
176	Phosphorylation	VRPPPMLTSPNDFPN CCCCCCCCCCCCCCH	35.57	17330950
177	Phosphorylation	RPPPMLTSPNDFPNW CCCCCCCCCCCCCHH	20.11	17330950
186	Ubiquitination	NDFPNWVKTYIKFLQ CCCCHHHHHHHHHHH	27.50	17644757
190	Ubiquitination	NWVKTYIKFLQNSNL HHHHHHHHHHHCCCC	29.61	17644757
203	Phosphorylation	NLGGIIPTVNGKPVR CCCCEEECCCCEECE	19.05	24909858
207	Ubiquitination	IIPTVNGKPVRQITD EEECCCCEECEECCH	34.83	23749301
238	Ubiquitination	QFLPTWVKDILSVDY HCCCHHHHHHHCCCH	30.52	15699485
250	Ubiquitination	VDYTDIMKILSKSIE CCHHHHHHHHHHHHH	40.61	24961812
255	Phosphorylation	IMKILSKSIEKMQSD HHHHHHHHHHHHHHC	32.38	21440633
261	Phosphorylation	KSIEKMQSDTQEAND HHHHHHHHCCHHHHH	38.84	28132839
263	Phosphorylation	IEKMQSDTQEANDIV HHHHHHCCHHHHHHH	33.29	28132839
280	Phosphorylation	ANLQYNGSTPADAFE HHCEECCCCHHHHHH	27.81	28889911
281	Phosphorylation	NLQYNGSTPADAFET HCEECCCCHHHHHHH	24.72	27214570
289	Ubiquitination	PADAFETKVTNIIDR HHHHHHHHHHHHHHH	39.60	17644757
307	Ubiquitination	NGIHINNKVACQLIM CCCCCCCHHHHHHHH	27.07	17644757
318	Phosphorylation	QLIMRGLSGEYKFLR HHHHCCCCCCHHHHH	32.19	21440633
322	Ubiquitination	RGLSGEYKFLRYTRH CCCCCCHHHHHHHCH	33.35	23749301
353	Phosphorylation	IYEEQQGSRNSKPNY HHHHHCCCCCCCCCC	24.77	28889911
357	Ubiquitination	QQGSRNSKPNYRRNP HCCCCCCCCCCCCCC	40.61	22817900
365	Phosphorylation	PNYRRNPSDEKNDSR CCCCCCCCCCCCCCC	63.05	28889911
371	Phosphorylation	PSDEKNDSRSYTNTT CCCCCCCCCCCCCCC	32.30	17287358
373	Phosphorylation	DEKNDSRSYTNTTKP CCCCCCCCCCCCCCC	40.02	25521595
374	Phosphorylation	EKNDSRSYTNTTKPK CCCCCCCCCCCCCCE	11.69	22890988
375	Phosphorylation	KNDSRSYTNTTKPKV CCCCCCCCCCCCCEE	27.60	21551504
377	Phosphorylation	DSRSYTNTTKPKVIA CCCCCCCCCCCEEEE	28.53	22890988
378	Phosphorylation	SRSYTNTTKPKVIAR CCCCCCCCCCEEEEC	47.63	22890988
379	Ubiquitination	RSYTNTTKPKVIARN CCCCCCCCCEEEECC	40.58	22817900
381	Ubiquitination	YTNTTKPKVIARNPQ CCCCCCCEEEECCCC	48.07	22817900
397	Phosphorylation	TNNSKSKTARAHNVS CCCCCCCCCHHCCCC	28.59	21551504
404	Phosphorylation	TARAHNVSTSNNSPS CCHHCCCCCCCCCCC	31.28	25533186
405	Phosphorylation	ARAHNVSTSNNSPST CHHCCCCCCCCCCCC	31.06	25533186
406	Phosphorylation	RAHNVSTSNNSPSTD HHCCCCCCCCCCCCC	26.89	21551504
409	Phosphorylation	NVSTSNNSPSTDNDS CCCCCCCCCCCCCCC	25.20	17330950
411	Phosphorylation	STSNNSPSTDNDSIS CCCCCCCCCCCCCCC	48.49	17330950
412	Phosphorylation	TSNNSPSTDNDSISK CCCCCCCCCCCCCCC	42.05	17330950
416	Phosphorylation	SPSTDNDSISKSTTE CCCCCCCCCCCCCCC	34.71	21551504
418	Phosphorylation	STDNDSISKSTTEPI CCCCCCCCCCCCCCE	25.22	25533186
419	Ubiquitination	TDNDSISKSTTEPIQ CCCCCCCCCCCCCEE	50.59	23749301
420	Phosphorylation	DNDSISKSTTEPIQL CCCCCCCCCCCCEEC	33.50	24909858
421	Phosphorylation	NDSISKSTTEPIQLN CCCCCCCCCCCEECC	38.63	28889911
422	Phosphorylation	DSISKSTTEPIQLNN CCCCCCCCCCEECCC	47.02	21551504
430	Ubiquitination	EPIQLNNKHDLHLGQ CCEECCCCCCCCCCH	37.11	22817900
438	Ubiquitination	HDLHLGQKLTESTVN CCCCCCHHCCHHHCC	56.42	17644757
440	Phosphorylation	LHLGQKLTESTVNHT CCCCHHCCHHHCCCC	34.62	19779198
442	Phosphorylation	LGQKLTESTVNHTNH CCHHCCHHHCCCCCC	32.21	17330950
443	Phosphorylation	GQKLTESTVNHTNHS CHHCCHHHCCCCCCC	21.06	17330950
447	Phosphorylation	TESTVNHTNHSDDEL CHHHCCCCCCCCCCC	29.44	19779198
450	Phosphorylation	TVNHTNHSDDELPGH HCCCCCCCCCCCCCE	49.15	28889911
471	Phosphorylation	ASRTLIRSAHHIHSA CCHHHHHHHHHHHHC	25.59	30377154
477	Phosphorylation	RSAHHIHSASSNPDI HHHHHHHHCCCCCCC	29.28	24909858
479	Phosphorylation	AHHIHSASSNPDINV HHHHHHCCCCCCCCC	33.39	19779198
480	Phosphorylation	HHIHSASSNPDINVV HHHHHCCCCCCCCCC	52.69	24909858
491	Ubiquitination	INVVDAQKRNIPINA CCCCCHHHCCCCCCE	49.48	23749301
511	Ubiquitination	FHFQDNTKTSIKVLH EEEECCCCCEEEEEE	46.67	17644757
515	Ubiquitination	DNTKTSIKVLHTPNI CCCCCEEEEEECCCH	38.21	17644757
543	Ubiquitination	DITACFTKNVLERSD CHHHHCCCCHHHCCC	25.47	17644757
559	Ubiquitination	TVLAPIVKYGDFYWV EEEEEEEECCCEEEE	44.21	17644757
568	Ubiquitination	GDFYWVSKKYLLPSN CCEEEEECEEECCCC	35.50	17644757
569	Ubiquitination	DFYWVSKKYLLPSNI CEEEEECEEECCCCC	33.36	24961812
574	Phosphorylation	SKKYLLPSNISVPTI ECEEECCCCCCCCCC	46.92	30377154
577	Phosphorylation	YLLPSNISVPTINNV EECCCCCCCCCCCCC	26.71	25521595
580	Phosphorylation	PSNISVPTINNVHTS CCCCCCCCCCCCCCC	33.89	28889911
586	Phosphorylation	PTINNVHTSESTRKY CCCCCCCCCCCCCCC	29.88	25521595
589	Phosphorylation	NNVHTSESTRKYPYP CCCCCCCCCCCCCCH	33.02	25521595
592	Ubiquitination	HTSESTRKYPYPFIH CCCCCCCCCCCHHHH	51.14	17644757
615	Ubiquitination	QTIRYSLKNNTITYF CEEEEECCCCEEEEE	42.06	15699485
644	Ubiquitination	CPDCLIGKSTKHRHI CCCCEECCCCCCCCC	48.21	15699485
657	Ubiquitination	HIKGSRLKYQNSYEP CCCCCCCCCCCCCCC	43.62	17644757
681	Ubiquitination	GPVHNLPKSAPSYFI CCCCCCCCCCCCEEE	63.52	17644757
696	Ubiquitination	SFTDETTKFRWVYPL EEECCCCCEEEEEEC	40.11	17644757
723	Ubiquitination	TTILAFIKNQFQASV HHHHHHHHHHHHCEE	37.94	15699485
748	Ubiquitination	YTNRTLHKFLEKNGI CCHHHHHHHHHHCCC	55.55	23749301
752	Ubiquitination	TLHKFLEKNGITPCY HHHHHHHHCCCCCCE	63.72	23749301
812	Phosphorylation	IVRNSLASPKSKKSA HHHHHCCCCCCHHHH	37.85	25752575
850	Ubiquitination	NDHNPNSKIHPRGIP CCCCCCCCCCCCCCC	52.23	23749301
878	Ubiquitination	IIYLPSLKKTVDTTN EEEECCCCEEECCCC	51.22	17644757
879	Ubiquitination	IYLPSLKKTVDTTNY EEECCCCEEECCCCE	60.10	17644757
880	Phosphorylation	YLPSLKKTVDTTNYV EECCCCEEECCCCEE	23.25	27017623
883	Phosphorylation	SLKKTVDTTNYVILQ CCCEEECCCCEEEEC	16.77	27017623
884	Phosphorylation	LKKTVDTTNYVILQG CCEEECCCCEEEECC	21.79	27017623
886	Phosphorylation	KTVDTTNYVILQGKE EEECCCCEEEECCCH	6.18	27017623
892	Ubiquitination	NYVILQGKESRLDQF CEEEECCCHHHHHHC	39.29	24961812
894	Phosphorylation	VILQGKESRLDQFNY EEECCCHHHHHHCCC	41.45	27017623
905	Phosphorylation	QFNYDALTFDEDLNR HCCCCCCCCCHHHHH	30.66	27017623
936	Phosphorylation	SNDLNIESDHDFQSD CCCCCCCCCCCHHHH	36.13	19779198
942	Phosphorylation	ESDHDFQSDIELHPE CCCCCHHHHHCCCHH	40.32	28889911
956	Phosphorylation	EQLRNVLSKAVSPTD HHHHHHHHHCCCCCC	17.81	17330950
957	Ubiquitination	QLRNVLSKAVSPTDS HHHHHHHHCCCCCCC	48.96	17644757
960	Phosphorylation	NVLSKAVSPTDSTPP HHHHHCCCCCCCCCC	27.26	17330950
962	Phosphorylation	LSKAVSPTDSTPPST HHHCCCCCCCCCCCC	34.77	17330950
964	Phosphorylation	KAVSPTDSTPPSTHT HCCCCCCCCCCCCCC	45.34	17330950
965	Phosphorylation	AVSPTDSTPPSTHTE CCCCCCCCCCCCCCH	41.87	17330950
968	Phosphorylation	PTDSTPPSTHTEDSK CCCCCCCCCCCHHCC	33.74	22890988
969	Phosphorylation	TDSTPPSTHTEDSKR CCCCCCCCCCHHCCC	38.29	22890988
971	Phosphorylation	STPPSTHTEDSKRVS CCCCCCCCHHCCCCC	41.39	22890988
974	Phosphorylation	PSTHTEDSKRVSKTN CCCCCHHCCCCCCCC	19.01	22890988
975	Ubiquitination	STHTEDSKRVSKTNI CCCCHHCCCCCCCCC	69.96	22817900
978	Phosphorylation	TEDSKRVSKTNIRAP CHHCCCCCCCCCCCC	37.48	21440633
979	Ubiquitination	EDSKRVSKTNIRAPR HHCCCCCCCCCCCCC	42.61	22817900
980	Phosphorylation	DSKRVSKTNIRAPRE HCCCCCCCCCCCCCC	28.50	28889911
993	Phosphorylation	REVDPNISESNILPS CCCCCCCCHHHCCCC	41.43	25533186
995	Phosphorylation	VDPNISESNILPSKK CCCCCCHHHCCCCCC	23.52	22890988
1000	Phosphorylation	SESNILPSKKRSSTP CHHHCCCCCCCCCCC	47.57	22890988
1001	Ubiquitination	ESNILPSKKRSSTPQ HHHCCCCCCCCCCCC	50.71	17644757
1002	Ubiquitination	SNILPSKKRSSTPQI HHCCCCCCCCCCCCC	62.95	17644757
1004	Phosphorylation	ILPSKKRSSTPQISD CCCCCCCCCCCCCCC	47.66	21440633
1005	Phosphorylation	LPSKKRSSTPQISDI CCCCCCCCCCCCCCC	48.41	17330950
1006	Phosphorylation	PSKKRSSTPQISDIE CCCCCCCCCCCCCCC	22.06	17330950
1010	Phosphorylation	RSSTPQISDIESTGS CCCCCCCCCCCCCCC	27.56	28889911
1014	Phosphorylation	PQISDIESTGSGGMH CCCCCCCCCCCCCCC	38.10	28889911
1015	Phosphorylation	QISDIESTGSGGMHR CCCCCCCCCCCCCCC	23.68	27017623
1032	Phosphorylation	VPLLAPMSQSNTHES CCEEEECCCCCCCCC	29.42	28889911
1036	Phosphorylation	APMSQSNTHESSHAS EECCCCCCCCCCCCC	32.06	28889911
1039	Phosphorylation	SQSNTHESSHASKSK CCCCCCCCCCCCCCC	21.59	28889911
1043	Phosphorylation	THESSHASKSKDFRH CCCCCCCCCCCCCCC	31.85	28889911
1045	Phosphorylation	ESSHASKSKDFRHSD CCCCCCCCCCCCCCC	34.66	28889911
1051	Phosphorylation	KSKDFRHSDSYSDNE CCCCCCCCCCCCCCC	24.81	20377248
1053	Phosphorylation	KDFRHSDSYSDNETN CCCCCCCCCCCCCCC	29.56	25533186
1054	Phosphorylation	DFRHSDSYSDNETNH CCCCCCCCCCCCCCC	25.65	20377248
1055	Phosphorylation	FRHSDSYSDNETNHT CCCCCCCCCCCCCCC	37.60	17330950
1059	Phosphorylation	DSYSDNETNHTNVPI CCCCCCCCCCCCCCC	38.26	21440633
1062	Phosphorylation	SDNETNHTNVPISST CCCCCCCCCCCCCCC	39.73	17330950
1067	Phosphorylation	NHTNVPISSTGGTNN CCCCCCCCCCCCCCC	18.77	20377248
1068	Phosphorylation	HTNVPISSTGGTNNK CCCCCCCCCCCCCCC	31.62	20377248
1072	Phosphorylation	PISSTGGTNNKTVPQ CCCCCCCCCCCCCCC	36.64	28889911
1081	Phosphorylation	NKTVPQTSEQETEKR CCCCCCCCHHHHHHH	31.84	23749301
1087	Ubiquitination	TSEQETEKRIIHRSP CCHHHHHHHHHHCCC	57.21	22817900
1093	Phosphorylation	EKRIIHRSPSIDTSS HHHHHHCCCCCCCCC	14.61	17330950
1095	Phosphorylation	RIIHRSPSIDTSSSE HHHHCCCCCCCCCCC	34.05	17330950
1098	Phosphorylation	HRSPSIDTSSSESNS HCCCCCCCCCCCCCC	28.92	17287358
1099	Phosphorylation	RSPSIDTSSSESNSL CCCCCCCCCCCCCCC	28.28	28889911
1100	Phosphorylation	SPSIDTSSSESNSLH CCCCCCCCCCCCCCE	39.97	28889911
1101	Phosphorylation	PSIDTSSSESNSLHH CCCCCCCCCCCCCEE	44.82	28889911
1103	Phosphorylation	IDTSSSESNSLHHVV CCCCCCCCCCCEEEE	33.40	19779198
1105	Phosphorylation	TSSSESNSLHHVVPI CCCCCCCCCEEEEEE	38.06	28889911
1113	Ubiquitination	LHHVVPIKTSDTCPK CEEEEEEECCCCCCC	35.59	17644757
1120	Ubiquitination	KTSDTCPKENTEESI ECCCCCCCCCCCCCE	66.79	17644757
1156	Phosphorylation	KELPPINSHQTNSSL CCCCCCCCCCCCCCC	20.07	28889911
1159	Phosphorylation	PPINSHQTNSSLGGI CCCCCCCCCCCCCCC	31.48	28889911
1161	Phosphorylation	INSHQTNSSLGGIGD CCCCCCCCCCCCCCC	30.26	21440633
1162	Phosphorylation	NSHQTNSSLGGIGDS CCCCCCCCCCCCCCC	32.86	25752575
1173	Phosphorylation	IGDSNAYTTINSKKR CCCCCCCCEECCCCC	20.84	19779198
1178	Ubiquitination	AYTTINSKKRSLEDN CCCEECCCCCCCCCC	47.95	15699485
1179	Ubiquitination	YTTINSKKRSLEDNE CCEECCCCCCCCCCC	47.22	15699485
1181	Phosphorylation	TINSKKRSLEDNETE EECCCCCCCCCCCCE	45.02	17330950
1187	Phosphorylation	RSLEDNETEIKVSRD CCCCCCCCEEEEEHH	49.63	28132839
1190	Ubiquitination	EDNETEIKVSRDTWN CCCCCEEEEEHHCCC	28.11	23749301
1192	Phosphorylation	NETEIKVSRDTWNTK CCCEEEEEHHCCCCC	21.31	30377154
1199	Ubiquitination	SRDTWNTKNMRSLEP EHHCCCCCCCCCCCC	45.60	22817900
1220	Ubiquitination	IHLIAAVKAVKSIKP HHHHHHHHHHHCCCC	42.61	17644757
1242	Ubiquitination	DEAITYNKDIKEKEK CCEECCCCCHHHHHH	50.87	23749301
1245	Ubiquitination	ITYNKDIKEKEKYIQ ECCCCCHHHHHHHHH	73.24	22817900
1247	Ubiquitination	YNKDIKEKEKYIQAY CCCCHHHHHHHHHHH	55.28	22817900
1263	Ubiquitination	KEVNQLLKMKTWDTD HHHHHHHHCCCCCCC	47.12	22817900
1265	Ubiquitination	VNQLLKMKTWDTDRY HHHHHHCCCCCCCCC	44.89	22817900
1293	Ubiquitination	SMFIFNRKRDGTHKA EEEEEECCCCCCCCE	56.81	17644757
1385	Ubiquitination	KKSLYGLKQSGANWY HHHHHCCHHCCCCHH	37.75	15699485
1387	Phosphorylation	SLYGLKQSGANWYET HHHCCHHCCCCHHHH	37.98	19779198
1392	Phosphorylation	KQSGANWYETIKSYL HHCCCCHHHHHHHHH	11.73	19779198
1396	Ubiquitination	ANWYETIKSYLIKQC CCHHHHHHHHHHHHH	40.23	15699485
1401	Ubiquitination	TIKSYLIKQCGMEEV HHHHHHHHHHCCHHH	36.62	24961812
1440	Ubiquitination	SKDLNANKKIITTLK HCCCCCCHHHHHHHH	42.83	17644757
1441	Ubiquitination	KDLNANKKIITTLKK CCCCCCHHHHHHHHH	38.87	17644757
1447	Ubiquitination	KKIITTLKKQYDTKI HHHHHHHHHHCCCEE	35.42	17644757
1448	Ubiquitination	KIITTLKKQYDTKII HHHHHHHHHCCCEEE	58.14	17644757
1453	Ubiquitination	LKKQYDTKIINLGES HHHHCCCEEEECCCC	38.40	17644757
1474	Ubiquitination	DILGLEIKYQRGKYM EEECEEEEEECCCCC	26.42	17644757
1480	Phosphorylation	IKYQRGKYMKLGMEN EEEECCCCCCCCCCC	11.42	19779198
1482	Ubiquitination	YQRGKYMKLGMENSL EECCCCCCCCCCCCC	38.51	15699485
1492	Ubiquitination	MENSLTEKIPKLNVP CCCCCCCCCCCCCCC	60.10	23749301
1495	Ubiquitination	SLTEKIPKLNVPLNP CCCCCCCCCCCCCCC	57.05	22817900
1503	Ubiquitination	LNVPLNPKGRKLSAP CCCCCCCCCCCCCCC	70.99	22817900
1506	Ubiquitination	PLNPKGRKLSAPGQP CCCCCCCCCCCCCCC	56.30	22817900
1508	Phosphorylation	NPKGRKLSAPGQPGL CCCCCCCCCCCCCCE	35.14	28889911
1538	Ubiquitination	MKVHEMQKLIGLASY HHHHHHHHHHHHHHH	40.54	17644757
1549	Ubiquitination	LASYVGYKFRFDLLY HHHHCCHHHHHHHHH	24.92	22106047
1604	Ubiquitination	KPVKPTNKLVVISDA CCCCCCCCEEEEECC	45.17	17644757
1620	Ubiquitination	YGNQPYYKSQIGNIY CCCCCCEECCCCCEE	30.00	17644757
1632	Ubiquitination	NIYLLNGKVIGGKST CEEEECCEEECCCCC	29.61	17644757
1640	Ubiquitination	VIGGKSTKASLTCTS EECCCCCCEEEEECC	42.97	15699485
1675	Ubiquitination	HLVQELNKKPITKGL HHHHHHHCCCCCCCC	72.97	15699485
1676	Ubiquitination	LVQELNKKPITKGLL HHHHHHCCCCCCCCC	40.35	15699485
1687	Ubiquitination	KGLLTDSKSTISIII CCCCCCCCCEEEEEE	55.20	17644757
1700	Ubiquitination	IISNNEEKFRNRFFG EECCCHHHHHHHHCC	43.37	17644757
1709	Ubiquitination	RNRFFGTKAMRLRDE HHHHCCHHHCHHHHC	40.33	23749301
1730	Ubiquitination	HVCYIETKKNIADVM EEEEEECCCCHHHHH	30.91	17644757
1731	Ubiquitination	VCYIETKKNIADVMT EEEEECCCCHHHHHC	62.09	23749301
1738	Phosphorylation	KNIADVMTKPLPIKT CCHHHHHCCCCCCCC	29.38	20377248
1739	Ubiquitination	NIADVMTKPLPIKTF CHHHHHCCCCCCCCC	26.85	23749301
1744	Ubiquitination	MTKPLPIKTFKLLTN HCCCCCCCCCHHHHC	46.07	22817900
1747	Ubiquitination	PLPIKTFKLLTNKWI CCCCCCCHHHHCCCC	48.06	15699485

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of YE12B_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of YE12B_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of YE12B_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of YE12B_YEAST !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of YE12B_YEAST

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-13, AND MASS SPECTROMETRY.	15665377 [Abstract]
Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-942 AND THR-1006, ANDMASS SPECTROMETRY.	18407956 [Abstract]
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-13, AND MASS SPECTROMETRY.	15665377 [Abstract]