RS26B_YEAST - dbPTM
RS26B_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RS26B_YEAST
UniProt AC P39939
Protein Name 40S ribosomal protein S26-B {ECO:0000303|PubMed:9559554}
Gene Name RPS26B {ECO:0000303|PubMed:9559554}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 119
Subcellular Localization Cytoplasm .
Protein Description Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel..
Protein Sequence MPKKRASNGRNKKGRGHVKPVRCVNCSKSIPKDKAIKRMAIRNIVEAAAVRDLSEASVYPEYALPKTYNKLHYCVSCAIHARIVRVRSREDRKNRAPPQRPRFNRDNKVSPAAAAKKAL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
27PhosphorylationPVRCVNCSKSIPKDK
CEEECCCCCCCCCCH		25.0027717283
28UbiquitinationVRCVNCSKSIPKDKA
EEECCCCCCCCCCHH		55.3823749301
32UbiquitinationNCSKSIPKDKAIKRM
CCCCCCCCCHHHHHH		70.9122817900
34UbiquitinationSKSIPKDKAIKRMAI
CCCCCCCHHHHHHHH		59.1322817900
37UbiquitinationIPKDKAIKRMAIRNI
CCCCHHHHHHHHHHH		40.7722817900
54PhosphorylationAAAVRDLSEASVYPE
HHHHCCHHHHCCCCH		35.0922369663
57PhosphorylationVRDLSEASVYPEYAL
HCCHHHHCCCCHHHC		20.3822890988
59PhosphorylationDLSEASVYPEYALPK
CHHHHCCCCHHHCCC		6.4522890988
62PhosphorylationEASVYPEYALPKTYN
HHCCCCHHHCCCCCC		14.6622890988
66UbiquitinationYPEYALPKTYNKLHY
CCHHHCCCCCCHHHH		65.5723749301
70UbiquitinationALPKTYNKLHYCVSC
HCCCCCCHHHHHHHH		26.6523749301
108UbiquitinationPRFNRDNKVSPAAAA
CCCCCCCCCCHHHHH		48.6723749301
108AcetylationPRFNRDNKVSPAAAA
CCCCCCCCCCHHHHH		48.6722865919
110PhosphorylationFNRDNKVSPAAAAKK
CCCCCCCCHHHHHHH		15.4925704821
116UbiquitinationVSPAAAAKKAL----
CCHHHHHHHHC----		33.5823749301
116SuccinylationVSPAAAAKKAL----
CCHHHHHHHHC----		33.5823954790
117UbiquitinationSPAAAAKKAL-----
CHHHHHHHHC-----		50.6317644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RS26B_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RS26B_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RS26B_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TSR2_YEASTTSR2physical
10688190
FBRL_YEASTNOP1physical
16554755
MAM33_YEASTMAM33physical
16554755
RPA49_YEASTRPA49physical
16554755
CMR1_YEASTCMR1genetic
22842922
ERJ5_YEASTERJ5genetic
27708008
RS23A_YEASTRPS23Agenetic
27708008
RS23B_YEASTRPS23Agenetic
27708008
SNG1_YEASTSNG1genetic
27708008
RS10B_YEASTRPS10Bgenetic
27708008
ECM15_YEASTECM15genetic
27708008
RTG3_YEASTRTG3genetic
27708008
HPC2_YEASTHPC2genetic
27708008
RV161_YEASTRVS161genetic
27708008
PAT1_YEASTPAT1genetic
27708008
NHP10_YEASTNHP10genetic
27708008
TPS2_YEASTTPS2genetic
27708008
HNT2_YEASTHNT2genetic
27708008
LSM6_YEASTLSM6genetic
27708008
AAKG_YEASTSNF4genetic
27708008
XRN1_YEASTXRN1genetic
27708008
COS12_YEASTCOS12genetic
27708008
DBF2_YEASTDBF2genetic
27708008
YG37_YEASTYGR127Wgenetic
27708008
QCR9_YEASTQCR9genetic
27708008
GTR1_YEASTGTR1genetic
27708008
SSO2_YEASTSSO2genetic
27708008
PFKA2_YEASTPFK2genetic
27708008
MDM38_YEASTMDM38genetic
27708008
ZEO1_YEASTZEO1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RS26B_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-54 AND SER-57, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-54, AND MASSSPECTROMETRY.

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