COS12_YEAST - dbPTM
COS12_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID COS12_YEAST
UniProt AC P53053
Protein Name Protein COS12
Gene Name COS12
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 380
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description
Protein Sequence MDGAKFENTVAFLPSEIFDCYNSTLPKNVFRSFVTWSCYEKFNSLEFRTWLLMWLPLIIAWKIRGKRHYLVIVTALMFEVLYFLWTYSYIFRERTLGKQVSQFAKEIITNTPGIDTEDWERVAVNFNSYLYENKLWNTEYFFFDGSSCQEAFRKMLLEPFSLKKNDFANAKVPDGSVCYTEKALQVYFTQIERKWHWINSEGFLHNKTTQSVQFSKHGYGSKLLWAFKEVTIMNSRFAFFSIAYLNGLLTIPRLRNSLHILYVCAVLSSMIIEYLIGIDKFRFKSMNLIHKLQFLSYITCGHEKSDATNWSQIAKRTNTYMFEQKIWNSPILFSDGIDCEKFFKWYFSTPVSSQASLSVGSTDFELWPYIKEAQSACNDV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
32PhosphorylationLPKNVFRSFVTWSCY
CCHHHHHHHCHHHHH		16.7729734811
35PhosphorylationNVFRSFVTWSCYEKF
HHHHHHCHHHHHHHH		15.0629734811
37PhosphorylationFRSFVTWSCYEKFNS
HHHHCHHHHHHHHCC		9.4629734811
308PhosphorylationGHEKSDATNWSQIAK
CCCCCCCCCHHHHHH		42.0627017623
311PhosphorylationKSDATNWSQIAKRTN
CCCCCCHHHHHHHHC		17.4927017623
317PhosphorylationWSQIAKRTNTYMFEQ
HHHHHHHHCCCEEEE		31.0727017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of COS12_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of COS12_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of COS12_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CND1_YEASTYCS4physical
18467557
SFC1_YEASTSFC1physical
16093310
DMA2_YEASTDMA2genetic
27708008
TPS1_YEASTTPS1genetic
27708008
CCZ1_YEASTCCZ1genetic
27708008
PAT1_YEASTPAT1genetic
27708008
FCY2_YEASTFCY2genetic
27708008
STB5_YEASTSTB5genetic
27708008
OSH6_YEASTOSH6genetic
27708008
SST2_YEASTSST2genetic
27708008
CY1_YEASTCYT1genetic
27708008
CR3L1_HUMANCREB3L1physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of COS12_YEAST

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Related Literatures of Post-Translational Modification

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