dbPTM

FCY2_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FCY2_YEAST
UniProt AC	P17064
Protein Name	Purine-cytosine permease FCY2
Gene Name	FCY2
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	533
Subcellular Localization	Membrane Multi-pass membrane protein.
Protein Description	This permease has a broad specificity towards purines, and also transport cytosine and 5-methylcytosine but neither uracil nor thymine..
Protein Sequence	MLEEGNNVYEIQDLEKRSPVIGSSLENEKKVAASETFTATSEDDQQYIVESSEATKLSWFHKFFASLNAETKGVEPVTEDEKTDDSILNAASMWFSANMVIASYALGALGPMVFGLNFGQSVLVIIFFNIMGLIFVAFFSVFGAELGLRQMILSRYLVGNVTARIFSLINVIACVGWGIVNTSVSAQLLNMVNEGSGHVCPIWAGCLIIIGGTVLVTFFGYSVIHAYEKWSWVPNFAVFLVIIAQLSRSGKFKGGEWVGGATTAGSVLSFGSSIFGFAAGWTTYAADYTVYMPKSTNKYKIFFSLVAGLAFPLFFTMILGAASAMAALNDPTWKAYYDKNAMGGVIYAILVPNSLNGFGQFCCVLLALSTIANNIPNMYTVALSAQALWAPLAKIPRVVWTMAGNAATLGISIPATYYFDGFMENFMDSIGYYLAIYIAISCSEHFFYRRSFSAYNIDDWDNWEHLPIGIAGTAALIVGAFGVALGMCQTYWVGEIGRLIGKYGGDIGFELGASWAFIIYNILRPLELKYFGR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Ubiquitination	YEIQDLEKRSPVIGS EEEECHHHHCCCCCC	66.53	23749301
18	Phosphorylation	IQDLEKRSPVIGSSL EECHHHHCCCCCCCC	34.29	22369663
23	Phosphorylation	KRSPVIGSSLENEKK HHCCCCCCCCCCCCC	22.18	22369663
24	Phosphorylation	RSPVIGSSLENEKKV HCCCCCCCCCCCCCE	34.19	22369663
29	Ubiquitination	GSSLENEKKVAASET CCCCCCCCCEEEECE	65.22	23749301
30	Ubiquitination	SSLENEKKVAASETF CCCCCCCCEEEECEE	30.81	23749301
40	Phosphorylation	ASETFTATSEDDQQY EECEEEECCCCCCEE	29.59	28889911
41	Phosphorylation	SETFTATSEDDQQYI ECEEEECCCCCCEEE	36.24	29734811

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FCY2_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FCY2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FCY2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SOP4_YEAST	SOP4	physical	18467557
RAD52_YEAST	RAD52	genetic	18612078
PHO88_YEAST	PHO88	physical	16093310
PUR7_YEAST	ADE1	genetic	21623372
PUR4_YEAST	ADE6	genetic	21623372
PUR6_YEAST	ADE2	genetic	21623372
PUR1_YEAST	ADE4	genetic	21623372
PUR92_YEAST	ADE17	genetic	21623372
PUR2_YEAST	ADE5,7	genetic	21623372
GLYC_YEAST	SHM2	genetic	21623372
ADE_YEAST	AAH1	genetic	21623372
PUR3_YEAST	ADE8	genetic	21623372
FUMH_YEAST	FUM1	genetic	21623372
COQ7_YEAST	CAT5	genetic	21623372
SERB_YEAST	SER2	genetic	21623372
PDX3_YEAST	PDX3	genetic	21623372
SOP4_YEAST	SOP4	physical	22615397
YG19_YEAST	YGR015C	genetic	27708008
YG1C_YEAST	YGR018C	genetic	27708008
PUR7_YEAST	ADE1	genetic	27708008
RTG3_YEAST	RTG3	genetic	27708008
PUR3_YEAST	ADE8	genetic	27708008
HXKA_YEAST	HXK1	genetic	27708008
MIG1_YEAST	MIG1	genetic	27708008
YGS6_YEAST	YGL176C	genetic	27708008
ARO8_YEAST	ARO8	genetic	27708008
PUR2_YEAST	ADE5,7	genetic	27708008
EIF2A_YEAST	YGR054W	genetic	27708008
ASK10_YEAST	ASK10	genetic	27708008
HGH1_YEAST	HGH1	genetic	27708008
CYPB_YEAST	CPR2	genetic	27708008
COX23_YEAST	COX23	genetic	27708008
ARO9_YEAST	ARO9	genetic	27708008
SNL1_YEAST	SNL1	genetic	27708008
YJU6_YEAST	YJL206C	genetic	27708008
YKE44_YEAST	YKL044W	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FCY2_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, AND MASSSPECTROMETRY.	15665377 [Abstract]