| UniProt ID | MIG1_YEAST | |
|---|---|---|
| UniProt AC | P27705 | |
| Protein Name | Regulatory protein MIG1 | |
| Gene Name | MIG1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 504 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Involved in glucose repression of the SUC, GAL and MAL genes as well as of the CAT8 gene. Binds to two sites in the upstream region of SUC2.. | |
| Protein Sequence | MQSPYPMTQVSNVDDGSLLKESKSKSKVAAKSEAPRPHACPICHRAFHRLEHQTRHMRIHTGEKPHACDFPGCVKRFSRSDELTRHRRIHTNSHPRGKRGRKKKVVGSPINSASSSATSIPDLNTANFSPPLPQQHLSPLIPIAIAPKENSSRSSTRKGRKTKFEIGESGGNDPYMVSSPKTMAKIPVSVKPPPSLALNNMNYQTSSASTALSSLSNSHSGSRLKLNALSSLQMMTPIASSAPRTVFIDGPEQKQLQQQQNSLSPRYSNTVILPRPRSLTDFQGLNNANPNNNGSLRAQTQSSVQLKRPSSVLSLNDLLVGQRNTNESDSDFTTGGEDEEDGLKDPSNSSIDNLEQDYLQEQSRKKSKTSTPTTMLSRSTSGTNLHTLGYVMNQNHLHFSSSSPDFQKELNNRLLNVQQQQQEQHTLLQSQNTSNQSQNQNQNQMMASSSSLSTTPLLLSPRVNMINTAISTQQTPISQSDSQVQELETLPPIRSLPLPFPHMD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MQSPYPMTQV -----CCCCCCCCCC | 25.71 | 30377154 | |
| 11 | Phosphorylation | PYPMTQVSNVDDGSL CCCCCCCCCCCCCCH | 22.71 | 30377154 | |
| 17 | Phosphorylation | VSNVDDGSLLKESKS CCCCCCCCHHCHHHC | 37.21 | 30377154 | |
| 80 | Phosphorylation | CVKRFSRSDELTRHR HHHHCCCCHHHHHCH | 33.95 | 29136822 | |
| 108 | Phosphorylation | RKKKVVGSPINSASS CCCCCCCCCCCCCCC | 15.82 | 21440633 | |
| 112 | Phosphorylation | VVGSPINSASSSATS CCCCCCCCCCCCCCC | 30.19 | 21440633 | |
| 114 | Phosphorylation | GSPINSASSSATSIP CCCCCCCCCCCCCCC | 25.33 | 21440633 | |
| 115 | Phosphorylation | SPINSASSSATSIPD CCCCCCCCCCCCCCC | 24.57 | 21551504 | |
| 116 | Phosphorylation | PINSASSSATSIPDL CCCCCCCCCCCCCCC | 32.82 | 21440633 | |
| 118 | Phosphorylation | NSASSSATSIPDLNT CCCCCCCCCCCCCCC | 29.18 | 21440633 | |
| 119 | Phosphorylation | SASSSATSIPDLNTA CCCCCCCCCCCCCCC | 31.66 | 21440633 | |
| 125 | Phosphorylation | TSIPDLNTANFSPPL CCCCCCCCCCCCCCC | 30.21 | 21551504 | |
| 163 | Acetylation | TRKGRKTKFEIGESG CCCCCCCEEECCCCC | 43.99 | 25381059 | |
| 175 | Phosphorylation | ESGGNDPYMVSSPKT CCCCCCCCEECCCCC | 17.01 | 22369663 | |
| 178 | Phosphorylation | GNDPYMVSSPKTMAK CCCCCEECCCCCCCC | 25.13 | 22369663 | |
| 179 | Phosphorylation | NDPYMVSSPKTMAKI CCCCEECCCCCCCCC | 21.00 | 22369663 | |
| 189 | Phosphorylation | TMAKIPVSVKPPPSL CCCCCCCCCCCCCCC | 21.04 | 19823750 | |
| 195 | Phosphorylation | VSVKPPPSLALNNMN CCCCCCCCCCCCCCC | 31.86 | 21440633 | |
| 203 | Phosphorylation | LALNNMNYQTSSAST CCCCCCCCCCCCHHH | 11.47 | 21440633 | |
| 205 | Phosphorylation | LNNMNYQTSSASTAL CCCCCCCCCCHHHHH | 17.81 | 20377248 | |
| 206 | Phosphorylation | NNMNYQTSSASTALS CCCCCCCCCHHHHHH | 14.37 | 21440633 | |
| 207 | Phosphorylation | NMNYQTSSASTALSS CCCCCCCCHHHHHHH | 29.62 | 20377248 | |
| 209 | Phosphorylation | NYQTSSASTALSSLS CCCCCCHHHHHHHHC | 19.03 | 20377248 | |
| 210 | Phosphorylation | YQTSSASTALSSLSN CCCCCHHHHHHHHCC | 31.19 | 20377248 | |
| 213 | Phosphorylation | SSASTALSSLSNSHS CCHHHHHHHHCCCCC | 27.11 | 20377248 | |
| 214 | Phosphorylation | SASTALSSLSNSHSG CHHHHHHHHCCCCCC | 36.35 | 20377248 | |
| 216 | Phosphorylation | STALSSLSNSHSGSR HHHHHHHCCCCCCCC | 37.93 | 20377248 | |
| 218 | Phosphorylation | ALSSLSNSHSGSRLK HHHHHCCCCCCCCHH | 18.69 | 20377248 | |
| 220 | Phosphorylation | SSLSNSHSGSRLKLN HHHCCCCCCCCHHHH | 37.98 | 20377248 | |
| 222 | Phosphorylation | LSNSHSGSRLKLNAL HCCCCCCCCHHHHHH | 37.14 | 20377248 | |
| 230 | Phosphorylation | RLKLNALSSLQMMTP CHHHHHHHHHCHHCC | 26.96 | 21440633 | |
| 231 | Phosphorylation | LKLNALSSLQMMTPI HHHHHHHHHCHHCCC | 24.38 | 21551504 | |
| 236 | Phosphorylation | LSSLQMMTPIASSAP HHHHCHHCCCCCCCC | 13.24 | 28132839 | |
| 241 | Phosphorylation | MMTPIASSAPRTVFI HHCCCCCCCCCEEEE | 33.02 | 27017623 | |
| 262 | Phosphorylation | QLQQQQNSLSPRYSN HHHHHHHCCCCCCCC | 26.36 | 22369663 | |
| 264 | Phosphorylation | QQQQNSLSPRYSNTV HHHHHCCCCCCCCCE | 13.73 | 22369663 | |
| 268 | Phosphorylation | NSLSPRYSNTVILPR HCCCCCCCCCEEECC | 27.57 | 27017623 | |
| 270 | Phosphorylation | LSPRYSNTVILPRPR CCCCCCCCEEECCCC | 11.72 | 21440633 | |
| 278 | Phosphorylation | VILPRPRSLTDFQGL EEECCCCCCCCCCCC | 38.00 | 22369663 | |
| 280 | Phosphorylation | LPRPRSLTDFQGLNN ECCCCCCCCCCCCCC | 35.69 | 22369663 | |
| 295 | Phosphorylation | ANPNNNGSLRAQTQS CCCCCCCCCCEECCC | 19.46 | 22369663 | |
| 300 | Phosphorylation | NGSLRAQTQSSVQLK CCCCCEECCCCEECC | 29.45 | 22369663 | |
| 302 | Phosphorylation | SLRAQTQSSVQLKRP CCCEECCCCEECCCC | 35.54 | 22369663 | |
| 303 | Phosphorylation | LRAQTQSSVQLKRPS CCEECCCCEECCCCC | 12.22 | 22369663 | |
| 307 | Acetylation | TQSSVQLKRPSSVLS CCCCEECCCCCCEEE | 45.21 | 25381059 | |
| 310 | Phosphorylation | SVQLKRPSSVLSLND CEECCCCCCEEEHHH | 36.79 | 22369663 | |
| 311 | Phosphorylation | VQLKRPSSVLSLNDL EECCCCCCEEEHHHE | 29.75 | 22369663 | |
| 314 | Phosphorylation | KRPSSVLSLNDLLVG CCCCCEEEHHHEEEC | 23.99 | 22369663 | |
| 328 | Phosphorylation | GQRNTNESDSDFTTG CCCCCCCCCCCCCCC | 44.47 | 21551504 | |
| 347 | Phosphorylation | EDGLKDPSNSSIDNL CCCCCCCCCCCCHHH | 60.52 | 19795423 | |
| 349 | Phosphorylation | GLKDPSNSSIDNLEQ CCCCCCCCCCHHHHH | 32.77 | 19795423 | |
| 350 | Phosphorylation | LKDPSNSSIDNLEQD CCCCCCCCCHHHHHH | 37.91 | 19795423 | |
| 363 | Phosphorylation | QDYLQEQSRKKSKTS HHHHHHHHHHHCCCC | 45.36 | 28889911 | |
| 367 | Phosphorylation | QEQSRKKSKTSTPTT HHHHHHHCCCCCCCC | 44.17 | 22369663 | |
| 369 | Phosphorylation | QSRKKSKTSTPTTML HHHHHCCCCCCCCCC | 44.94 | 22890988 | |
| 370 | Phosphorylation | SRKKSKTSTPTTMLS HHHHCCCCCCCCCCC | 35.81 | 22890988 | |
| 371 | Phosphorylation | RKKSKTSTPTTMLSR HHHCCCCCCCCCCCC | 29.86 | 22369663 | |
| 373 | Phosphorylation | KSKTSTPTTMLSRST HCCCCCCCCCCCCCC | 25.56 | 22890988 | |
| 374 | Phosphorylation | SKTSTPTTMLSRSTS CCCCCCCCCCCCCCC | 19.81 | 22890988 | |
| 377 | Phosphorylation | STPTTMLSRSTSGTN CCCCCCCCCCCCCCC | 17.23 | 22369663 | |
| 379 | Phosphorylation | PTTMLSRSTSGTNLH CCCCCCCCCCCCCHH | 24.45 | 28889911 | |
| 381 | Phosphorylation | TMLSRSTSGTNLHTL CCCCCCCCCCCHHHH | 44.88 | 28889911 | |
| 383 | Phosphorylation | LSRSTSGTNLHTLGY CCCCCCCCCHHHHEE | 34.08 | 19779198 | |
| 400 | Phosphorylation | NQNHLHFSSSSPDFQ CCCCCEECCCCHHHH | 20.68 | 19779198 | |
| 401 | Phosphorylation | QNHLHFSSSSPDFQK CCCCEECCCCHHHHH | 33.61 | 21551504 | |
| 402 | Phosphorylation | NHLHFSSSSPDFQKE CCCEECCCCHHHHHH | 44.70 | 28889911 | |
| 451 | Phosphorylation | QMMASSSSLSTTPLL HHHHHCCCCCCCCHH | 28.43 | 28889911 | |
| 455 | Phosphorylation | SSSSLSTTPLLLSPR HCCCCCCCCHHCCCC | 14.46 | 28889911 | |
| 472 | Phosphorylation | MINTAISTQQTPISQ CCCCHHHCCCCCCCC | 20.70 | 28889911 | |
| 475 | Phosphorylation | TAISTQQTPISQSDS CHHHCCCCCCCCCHH | 16.87 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MIG1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MIG1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MIG1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179; SER-218; SER-278;THR-280; SER-302; SER-310; SER-311; SER-314; SER-350; THR-371;SER-377; SER-379; SER-381; SER-402; SER-451 AND THR-455, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-311 AND SER-314, ANDMASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-311, AND MASSSPECTROMETRY. | |
