| UniProt ID | LYS14_YEAST | |
|---|---|---|
| UniProt AC | P40971 | |
| Protein Name | Lysine biosynthesis regulatory protein LYS14 | |
| Gene Name | LYS14 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 790 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Activates the transcription of lysine biosynthesis genes. This activation is dependent on the inducer alpha-aminoadipate semialdehyde and repressed by lysine.. | |
| Protein Sequence | MFESVNLDENSPEDRELAKVLSPPGSYLSPASLDSGSSFTNSGTSTSCFEPKNNLPSLSFLNARAGSLGGIFNHKQMTSPSNSNIGGENVESTTSSNDGSNENAGHPTTSEQDQNADHPTISQADDNGHSSLTPNPAVTSTVTDKKGNTVKRKYSRNGCSECKRRRMKCDETKPTCWQCARLNRQCVYVLNPKNKKRRTSNAQRVKEFRKHSTSLDNDHNNARKRQHSSCKAEKKKKVRQNLSEDTTDPKPITDNGKNVPLDEIESLEIPNLDLTTTMNGYDVNLLMQNLNDMVNMKLHDSYLLNEELKGLDLPDLDIPELLPASNVNSSVPISFLVNNVITFNTKLSSFKLGGIHDKYLKIFYYDCLDSIAPFFQNQGNPLRDILLSFAKNEAYLLSSILATGASIAYRKSNNLEDERNYCAYLSHCLSLLGEQFKNESNVLNRIEPIILTVIMLAWDCIYSMNSQWRSHLKGVTDLFKKINAGNSSKVLNVAKCWFKVMETFASISTVFGGSLIDNNDLDAIFDPYDYQYVDSLKFLNIMTPLNEFNLLRGHKEDFDLVIKEVFKSLNTIRSTEKNYFSKEEGLFTKKLDYLLLSSQTSSEKSKDQISYFNTQKILVEIDKQLDYEFIDKSGIIPSDNQSHPRISNIHDNAIDMVTLKNGEEVAISWYDISHQTQVLSFLLIVLLKLLGMPKESSTIQQVVKKIMSFFKFLDSDSPPQNSRTCYSNFAVLIAGLNAMDEETRAIVKRYYKINGGKFQKLTEHNLNRLEKVWYGKNQNYRLEEQDVLTW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 11 | Phosphorylation | SVNLDENSPEDRELA CCCCCCCCHHHHHHH | 27.84 | 22369663 | |
| 57 | Phosphorylation | EPKNNLPSLSFLNAR CCCCCCCCHHHHHHC | 39.55 | 22369663 | |
| 59 | Phosphorylation | KNNLPSLSFLNARAG CCCCCCHHHHHHCCC | 31.83 | 22369663 | |
| 67 | Phosphorylation | FLNARAGSLGGIFNH HHHHCCCCCCCCCCC | 23.90 | 21440633 | |
| 348 | Phosphorylation | ITFNTKLSSFKLGGI EEECHHHCCCCCCCC | 34.97 | 25533186 | |
| 597 | Phosphorylation | KLDYLLLSSQTSSEK HHHHHHHCCCCCCCC | 21.99 | 28889911 | |
| 598 | Phosphorylation | LDYLLLSSQTSSEKS HHHHHHCCCCCCCCC | 37.13 | 25752575 | |
| 600 | Phosphorylation | YLLLSSQTSSEKSKD HHHHCCCCCCCCCHH | 35.85 | 30377154 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LYS14_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LYS14_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LYS14_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SAHH_YEAST | SAH1 | physical | 11283351 | |
| DAM1_YEAST | DAM1 | physical | 11283351 | |
| RPN4_YEAST | RPN4 | genetic | 20959818 | |
| SPT3_YEAST | SPT3 | genetic | 20959818 | |
| HMO1_YEAST | HMO1 | genetic | 20959818 | |
| SPT8_YEAST | SPT8 | genetic | 20959818 | |
| DOA1_YEAST | DOA1 | genetic | 20959818 | |
| GCR2_YEAST | GCR2 | genetic | 20959818 | |
| UBP3_YEAST | UBP3 | genetic | 20959818 | |
| PHO23_YEAST | PHO23 | genetic | 20959818 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-597 AND SER-598, ANDMASS SPECTROMETRY. | |
