AATC_YEAST - dbPTM
AATC_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AATC_YEAST
UniProt AC P23542
Protein Name Aspartate aminotransferase, cytoplasmic
Gene Name AAT2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 418
Subcellular Localization Cytoplasm . Peroxisome . Targeted to peroxisomes in cells grown in oleate.
Protein Description Plays a key role in amino acid metabolism..
Protein Sequence MSATLFNNIELLPPDALFGIKQRYGQDQRATKVDLGIGAYRDDNGKPWVLPSVKAAEKLIHNDSSYNHEYLGITGLPSLTSNAAKIIFGTQSDAFQEDRVISVQSLSGTGALHISAKFFSKFFPDKLVYLSKPTWANHMAIFENQGLKTATYPYWANETKSLDLNGFLNAIQKAPEGSIFVLHSCAHNPTGLDPTSEQWVQIVDAIASKNHIALFDTAYQGFATGDLDKDAYAVRLGVEKLSTVSPVFVCQSFAKNAGMYGERVGCFHLALTKQAQNKTIKPAVTSQLAKIIRSEVSNPPAYGAKIVAKLLETPELTEQWHKDMVTMSSRITKMRHALRDHLVKLGTPGNWDHIVNQCGMFSFTGLTPQMVKRLEETHAVYLVASGRASIAGLNQGNVEYVAKAIDEVVRFYTIEAKL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSATLFNNI
------CCCCCCCCC		29.9322369663
2Acetylation------MSATLFNNI
------CCCCCCCCC		29.931859361
4Phosphorylation----MSATLFNNIEL
----CCCCCCCCCCC		25.2822369663
46AcetylationAYRDDNGKPWVLPSV
CEECCCCCCCCCCCH		41.7924489116
58AcetylationPSVKAAEKLIHNDSS
CCHHHHHHHHCCCCC		48.2724489116
64PhosphorylationEKLIHNDSSYNHEYL
HHHHCCCCCCCCCCC		39.7922369663
65PhosphorylationKLIHNDSSYNHEYLG
HHHCCCCCCCCCCCC		32.5822369663
66PhosphorylationLIHNDSSYNHEYLGI
HHCCCCCCCCCCCCC		25.2122369663
70PhosphorylationDSSYNHEYLGITGLP
CCCCCCCCCCCCCCC		11.5922369663
74PhosphorylationNHEYLGITGLPSLTS
CCCCCCCCCCCCCCC		30.7622369663
78PhosphorylationLGITGLPSLTSNAAK
CCCCCCCCCCCCCCH		49.6922369663
80PhosphorylationITGLPSLTSNAAKII
CCCCCCCCCCCCHHH		25.0322369663
81PhosphorylationTGLPSLTSNAAKIIF
CCCCCCCCCCCHHHH		29.7522369663
120PhosphorylationHISAKFFSKFFPDKL
EEEEEHHHHHCCCCE		31.5228889911
121AcetylationISAKFFSKFFPDKLV
EEEEHHHHHCCCCEE		45.9624489116
129PhosphorylationFFPDKLVYLSKPTWA
HCCCCEEEECCCCCC		18.7230377154
132AcetylationDKLVYLSKPTWANHM
CCEEEECCCCCCCCH		43.8224489116
161PhosphorylationYWANETKSLDLNGFL
CCCCCCCCCCCHHHH		34.2421440633
240AcetylationAVRLGVEKLSTVSPV
HHHHCCCCCCCCCCE		45.3824489116
255AcetylationFVCQSFAKNAGMYGE
EEEHHHHHHCCCCCC		45.3724489116
255N6-(pyridoxal phosphate)lysineFVCQSFAKNAGMYGE
EEEHHHHHHCCCCCC		45.37-
255OtherFVCQSFAKNAGMYGE
EEEHHHHHHCCCCCC		45.379655342
255UbiquitinationFVCQSFAKNAGMYGE
EEEHHHHHHCCCCCC		45.3723749301
281UbiquitinationQAQNKTIKPAVTSQL
HHCCCCCCHHHHHHH		31.9623749301
285PhosphorylationKTIKPAVTSQLAKII
CCCCHHHHHHHHHHH		16.9228889911
290UbiquitinationAVTSQLAKIIRSEVS
HHHHHHHHHHHHHCC		47.4623749301
290AcetylationAVTSQLAKIIRSEVS
HHHHHHHHHHHHHCC		47.4624489116
294PhosphorylationQLAKIIRSEVSNPPA
HHHHHHHHHCCCCCC		31.7621440633
297PhosphorylationKIIRSEVSNPPAYGA
HHHHHHCCCCCCHHH		39.3022369663
302PhosphorylationEVSNPPAYGAKIVAK
HCCCCCCHHHHHHHH		24.3222369663
305UbiquitinationNPPAYGAKIVAKLLE
CCCCHHHHHHHHHHC		33.0923749301
309AcetylationYGAKIVAKLLETPEL
HHHHHHHHHHCCHHH		42.5924489116
313PhosphorylationIVAKLLETPELTEQW
HHHHHHCCHHHHHHH		23.2521440633
317PhosphorylationLLETPELTEQWHKDM
HHCCHHHHHHHHHHH		25.1922369663
322AcetylationELTEQWHKDMVTMSS
HHHHHHHHHHHHHHH		44.5624489116
326PhosphorylationQWHKDMVTMSSRITK
HHHHHHHHHHHHHHH		12.5127017623
329PhosphorylationKDMVTMSSRITKMRH
HHHHHHHHHHHHHHH		19.5130377154
332PhosphorylationVTMSSRITKMRHALR
HHHHHHHHHHHHHHH		20.0627017623
362PhosphorylationVNQCGMFSFTGLTPQ
HHHCCCCEECCCCHH		17.0127017623
367PhosphorylationMFSFTGLTPQMVKRL
CCEECCCCHHHHHHH		16.9027017623
389PhosphorylationLVASGRASIAGLNQG
EEECCCCEECCCCCC		16.1722369663
400PhosphorylationLNQGNVEYVAKAIDE
CCCCCHHHHHHHHHH		11.0422369663
403AcetylationGNVEYVAKAIDEVVR
CCHHHHHHHHHHHHH		35.5124489116
417AcetylationRFYTIEAKL------
HHEEEEECC------		41.7722865919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AATC_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AATC_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AATC_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AATC_YEASTAAT2physical
9655342
RTG2_YEASTRTG2genetic
8913736
FUN30_YEASTFUN30physical
16554755
EF2_YEASTEFT2physical
16554755
G3P2_YEASTTDH2physical
16554755
PEX11_YEASTPEX11physical
18467557
LSP1_YEASTLSP1physical
18467557
FUI1_YEASTFUI1genetic
20093466
SMY2_YEASTSMY2genetic
20093466
SWD3_YEASTSWD3genetic
20093466
CRD1_YEASTCRD1genetic
20093466
RLA3_YEASTRPP1Bgenetic
20093466
ARO1_YEASTARO1genetic
20093466
MET10_YEASTMET10genetic
20093466
VMA21_YEASTVMA21genetic
20093466
BOP2_YEASTBOP2genetic
20093466
PML39_YEASTPML39genetic
20093466
PP2A4_YEASTPPG1genetic
20093466
CRC1_YEASTCRC1genetic
20093466
AZF1_YEASTAZF1genetic
20959818
PACC_YEASTRIM101genetic
20959818
MET28_YEASTMET28genetic
20959818
STP2_YEASTSTP2genetic
20959818
HAP4_YEASTHAP4genetic
20959818
BDF1_YEASTBDF1genetic
20959818
ERT1_YEASTERT1genetic
20959818
TOS8_YEASTTOS8genetic
20959818
SPT23_YEASTSPT23genetic
20959818
RPA34_YEASTRPA34genetic
20959818
SNT1_YEASTSNT1genetic
20959818
SPT8_YEASTSPT8genetic
20959818
SKN7_YEASTSKN7genetic
20959818
SAP30_YEASTSAP30genetic
20959818
CHD1_YEASTCHD1genetic
20959818
PFD5_YEASTGIM5genetic
20959818
UME1_YEASTUME1genetic
20959818
ISW2_YEASTISW2genetic
20959818
YG2A_YEASTYGR067Cgenetic
20959818
CUP9_YEASTCUP9genetic
20959818
SWR1_YEASTSWR1genetic
20959818
TEA1_YEASTTEA1genetic
20959818
HAP5_YEASTHAP5genetic
20959818
IES3_YEASTIES3genetic
20959818
ELP2_YEASTELP2genetic
20959818
RPH1_YEASTRPH1genetic
20959818
IES4_YEASTIES4genetic
20959818
SEM1_YEASTSEM1genetic
20959818
SUB1_YEASTSUB1genetic
20959818
PFD3_YEASTPAC10genetic
20959818
CTK1_YEASTCTK1genetic
20959818
PHO23_YEASTPHO23genetic
20959818
MTHR1_YEASTMET12genetic
21623372
TPS1_YEASTTPS1genetic
21623372
RSP5_YEASTRSP5genetic
27708008
ALG14_YEASTALG14genetic
27708008
CDC37_YEASTCDC37genetic
27708008
ERF3_YEASTSUP35genetic
27708008
RNA15_YEASTRNA15genetic
27708008
KTHY_YEASTCDC8genetic
27708008
KCY_YEASTURA6genetic
27708008
MIF2_YEASTMIF2genetic
27708008
ABF1_YEASTABF1genetic
27708008
SEC13_YEASTSEC13genetic
27708008
EI2BB_YEASTGCD7genetic
27708008
LST8_YEASTLST8genetic
27708008
DYR_YEASTDFR1genetic
27708008
SEC8_YEASTSEC8genetic
27708008
FAT1_YEASTFAT1genetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
BFA1_YEASTBFA1genetic
27708008
SRO7_YEASTSRO7genetic
27708008
PMP1_YEASTPMP1physical
26404137
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AATC_YEAST

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"The amino acid sequence of the aspartate aminotransferase frombaker's yeast (Saccharomyces cerevisiae).";
Cronin V.B., Maras B., Barra D., Doonan S.;
Biochem. J. 277:335-340(1991).
Cited for: PROTEIN SEQUENCE OF 2-418, ACETYLATION AT SER-2, AND ENZYME ACTIVITY.
Phosphorylation
ReferencePubMed
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-389, AND MASSSPECTROMETRY.

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