MET10_YEAST - dbPTM
MET10_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MET10_YEAST
UniProt AC P39692
Protein Name Sulfite reductase [NADPH] flavoprotein component
Gene Name MET10
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1035
Subcellular Localization
Protein Description This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate..
Protein Sequence MPVEFATNPFGEAKNATSLPKYGTPVTAISSVLFNNVDSIFAYKSFSQPDLLHQDLKKWSEKRGNESRGKPFFQELDIRSGAGLAPLGFSHGLKNTTAIVAPGFSLPYFINSLKTVSHDGKFLLNVGALNYDNATGSVTNDYVTALDAASKLKYGVVTPISANEVQSVALLALAIATFSNNSGAINLFDGLNYSKTVLPLVESVPEASILAKLSKVIAPDAAFDDVLDKFNELTGLRLHNFQYFGAQDAETVFITYGSLESELFNSAISGNNSKIGLINVRVPLPFNVAKFVTHVPSTTKQIVVIGQTLDGSSPSFLRSQVSAALFYHGRTSISVSEYIYQPDFIWSPKAVKSIVSSFIPEFTYNADSSFGEGFIYWASDKSINIDVASKLVKALSLEDGKFVSLRTKFDNLANAGTFQAQFVTSKEQIPVSNIDSTKLSVVEDVSLLKHLDVAATVAEQGSIALVSQKAVKDLDLNSVESYVKNLGIPESFLISIAKKNIKLFIIDGETTNDESKLSLFIQAVFWKLAFGLDVAECTNRIWKSIDSGADISAASISEFLTGAFKNFLSEVPLALYTKFSEINIEKKEDEEEPAALPIFVNETSFLPNNSTIEEIPLPETSEISDIAKKLSFKEAYEVENKLRPDLPVKNFVVKVKENRRVTPADYDRYIFHIEFDISGTGMTYDIGEALGIHARNNESLVKEFLTFYGLNESDVVLVPNKDNHHLLETRTVLQAFVENLDIFGKPPKRFYESLIPYASNEEEKKKLEDLVTPAGAVDLKRFQDVEYYTYADIFELFPSVRPSLEELVTIIEPLKRREYSIASSQKVHPNEVHLLIVVVDWVDNKGRKRYGQASKYISDLAVGSELVVSVKPSVMKLPPSPKQPVIMSGLGTGLAPFKAIVEEKLWQKQQGYEIGEVFLYLGSRHKREEYLYGELWEAYKDAGIITHIGAAFSRDQPQKIYIQDRIKENLDELKTAMIDNKGSFYLCGPTWPVPDITQALQDILAKDAEERGIKVDLDAAIEELKEASRYILEVY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
21UbiquitinationKNATSLPKYGTPVTA
CCCCCCCCCCCCHHH		62.7017644757
44UbiquitinationVDSIFAYKSFSQPDL
CCEECEECCCCCCCH		41.4117644757
57UbiquitinationDLLHQDLKKWSEKRG
CHHHHHHHHHHHHHC		61.5617644757
58UbiquitinationLLHQDLKKWSEKRGN
HHHHHHHHHHHHHCC		64.3517644757
70UbiquitinationRGNESRGKPFFQELD
HCCCCCCCCCCHHCC		37.2317644757
94UbiquitinationLGFSHGLKNTTAIVA
CCCCCCCCCCEEEEE		57.7617644757
114UbiquitinationPYFINSLKTVSHDGK
HHHHHCCCEECCCCE		46.8617644757
290AcetylationPLPFNVAKFVTHVPS
CCCCCHHHHEECCCC		35.7624489116
290UbiquitinationPLPFNVAKFVTHVPS
CCCCCHHHHEECCCC		35.7617644757
300UbiquitinationTHVPSTTKQIVVIGQ
ECCCCCCCEEEEEEE		37.8117644757
389PhosphorylationSINIDVASKLVKALS
CCCHHHHHHHHHHHC		26.7729688323
408UbiquitinationKFVSLRTKFDNLANA
CEEEEEECCCCHHCC		44.2617644757
426UbiquitinationQAQFVTSKEQIPVSN
EEEECCCCCCCCCCC		44.2517644757
438UbiquitinationVSNIDSTKLSVVEDV
CCCCCCCCEEEECCH		42.5917644757
449UbiquitinationVEDVSLLKHLDVAAT
ECCHHHHHHHCHHHH		47.6317644757
472UbiquitinationLVSQKAVKDLDLNSV
EEECHHHHCCCCHHH		58.3917644757
484UbiquitinationNSVESYVKNLGIPES
HHHHHHHHHCCCCHH		37.9217644757
543UbiquitinationECTNRIWKSIDSGAD
HHHHHHHHHCCCCCC		34.8517644757
565UbiquitinationEFLTGAFKNFLSEVP
HHHHHHHHHHHHHCC		46.3817644757
578UbiquitinationVPLALYTKFSEINIE
CCHHHHHHHHHCCCC		33.0817644757
603PhosphorylationLPIFVNETSFLPNNS
CCEEEECCCCCCCCC		21.4127017623
610PhosphorylationTSFLPNNSTIEEIPL
CCCCCCCCCCCCCCC		37.0827017623
611PhosphorylationSFLPNNSTIEEIPLP
CCCCCCCCCCCCCCC		34.2327017623
620PhosphorylationEEIPLPETSEISDIA
CCCCCCCCCHHHHHH		29.7127017623
621PhosphorylationEIPLPETSEISDIAK
CCCCCCCCHHHHHHH		31.1327017623
631PhosphorylationSDIAKKLSFKEAYEV
HHHHHHCCHHHHHHH		43.0528889911
641UbiquitinationEAYEVENKLRPDLPV
HHHHHHHCCCCCCCC		32.1617644757
649UbiquitinationLRPDLPVKNFVVKVK
CCCCCCCCCEEEEEE		42.6117644757
702UbiquitinationRNNESLVKEFLTFYG
CCCHHHHHHHHHHCC		48.3017644757
721UbiquitinationDVVLVPNKDNHHLLE
CEEEECCCCCCCHHH		54.5617644757
745UbiquitinationENLDIFGKPPKRFYE
HCCCCCCCCCHHHHH		47.6117644757
748UbiquitinationDIFGKPPKRFYESLI
CCCCCCCHHHHHHHC		64.7617644757
764UbiquitinationYASNEEEKKKLEDLV
CCCCHHHHHHHHHCC		59.4917644757
765UbiquitinationASNEEEKKKLEDLVT
CCCHHHHHHHHHCCC		66.9117644757
766UbiquitinationSNEEEKKKLEDLVTP
CCHHHHHHHHHCCCC		69.0817644757
780UbiquitinationPAGAVDLKRFQDVEY
CCCCCCHHHHCCCEE		46.8617644757
880PhosphorylationSVMKLPPSPKQPVIM
HHCCCCCCCCCCEEE		42.6721440633
882UbiquitinationMKLPPSPKQPVIMSG
CCCCCCCCCCEEECC		72.1317644757
898UbiquitinationGTGLAPFKAIVEEKL
CCCCHHHHHHHHHHH		35.8217644757
908UbiquitinationVEEKLWQKQQGYEIG
HHHHHHHHHCCCCHH		32.7617644757
940UbiquitinationGELWEAYKDAGIITH
HHHHHHHHHCCCEEE		48.4217644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MET10_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MET10_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MET10_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CYPD_YEASTCPR5physical
16554755
YRA1_YEASTYRA1physical
16554755
RV167_YEASTRVS167physical
16554755
MTC1_YEASTMTC1physical
16554755
EIF3B_YEASTPRT1physical
16554755
TPS2_YEASTTPS2genetic
21623372
ACON2_YEASTACO2genetic
21623372
PGM1_YEASTPGM1genetic
21623372
ATPF_YEASTATP4genetic
21623372
CEM1_YEASTCEM1genetic
21623372
ATP5E_YEASTATP15genetic
21623372
HTD2_YEASTHTD2genetic
21623372
MET18_YEASTMET18physical
22678362
KPC1_YEASTPKC1genetic
27708008
MCM7_YEASTMCM7genetic
27708008
CDC10_YEASTCDC10genetic
27708008
PRP9_YEASTPRP9genetic
27708008
PRP11_YEASTPRP11genetic
27708008
UAP1_YEASTQRI1genetic
27708008
CDC48_YEASTCDC48genetic
27708008
DAD1_YEASTDAD1genetic
27708008
RPC10_YEASTRPC11genetic
27708008
UTP6_YEASTUTP6genetic
27708008
SMT3_YEASTSMT3genetic
27708008
PSB3_YEASTPUP3genetic
27708008
ERG26_YEASTERG26genetic
27708008
PRS8_YEASTRPT6genetic
27708008
SDA1_YEASTSDA1genetic
27708008
CDC12_YEASTCDC12genetic
27708008
MOB1_YEASTMOB1genetic
27708008
PRP21_YEASTPRP21genetic
27708008
KTHY_YEASTCDC8genetic
27708008
RFC2_YEASTRFC2genetic
27708008
CDC11_YEASTCDC11genetic
27708008
ORC3_YEASTORC3genetic
27708008
SSL1_YEASTSSL1genetic
27708008
SMC4_YEASTSMC4genetic
27708008
CDC3_YEASTCDC3genetic
27708008
TAD3_YEASTTAD3genetic
27708008
MCM1_YEASTMCM1genetic
27708008
ROT1_YEASTROT1genetic
27708008
SEC63_YEASTSEC63genetic
27708008
IPL1_YEASTIPL1genetic
27708008
MED10_YEASTNUT2genetic
27708008
PMP1_YEASTPMP1physical
26404137
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MET10_YEAST

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Related Literatures of Post-Translational Modification

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