| UniProt ID | SDA1_YEAST | |
|---|---|---|
| UniProt AC | P53313 | |
| Protein Name | Protein SDA1 | |
| Gene Name | SDA1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 767 | |
| Subcellular Localization | Nucleus, nucleolus . | |
| Protein Description | Required for 60S pre-ribosomal subunits export to the cytoplasm. May also be required for 60S ribosomal subunit maturation and accumulation. Involved in G1 events and passage through start, and possibly actin cytoskeleton organization.. | |
| Protein Sequence | MGRRSRAAMLPTNIILLQNLVKRDPESYQEEFLQQYAHYESLRDIFMLNGLAGGDSAAATNGLDVGNGSSTMAGTNGTTMSTSTSQLIELVGFVSQVCSCFPRETANFPSELKQLLLEHHKSLPFELKEKILSCLTMLRNKDVITAEELIQSLFPLLVAYSSHGNSLGVNSHAKELRKIIYTNLISLLKSCNTNGKNQKLNKSTQAVCFNLLDQPDSQGIWATKLTRELWRRGIWDDSRTVEIMTQAALHQDVKIVMSGVMFFLDADREREENFEENSEDEDGFDLDALRHKMQVNKKTGRRGKKLENAIKTVKKKKKNGPGAPQGYLNFSAIHLLRDPQGFAEKLFKEHLSGKTKNKFDMEQKISLMQLLSRLIGTHKLIVLGIYTFFLKYLTPKQRDVTRIMSACAQACHDLVPPEVINVMVRKIADEFVSDGVANEVAAAGINTIREICSRAPLAIDEILLQDLVEYKGSKAKGVNMAAKSLIALYRDVAPEMLKKKDRGKNAAMEVQEAKKGGKDSKRPQFGADNSVQGIAGIELLAKWKKEHGEESENEDADANWEVDVDSEEDDVDGEWVTMDSDKEYDVDMEDSDDEKDNAKGKESDSDLELSDDDDEKEVKDEQEDADIDPEAAFREIASTRILTPADFAKLQELRNEESVAKIMGIHKQDKREELVDASTLTGPIKYKQSREERLQKVLEGREGRDKFGSRRGKRDNMRSTTNREKERRKNFVMSIHKRSVRGKQKMSLRDKQKVLRAHITKQKKKGY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 113 | Acetylation | ANFPSELKQLLLEHH CCCCHHHHHHHHHHH | 34.54 | 24489116 | |
| 278 | Phosphorylation | EENFEENSEDEDGFD HHCCHHCCCCCCCCC | 50.10 | 22369663 | |
| 311 | Acetylation | KKLENAIKTVKKKKK HHHHHHHHHHHHHHH | 44.87 | 22865919 | |
| 345 | Acetylation | DPQGFAEKLFKEHLS CCCHHHHHHHHHHHC | 56.65 | 24489116 | |
| 426 | Ubiquitination | VINVMVRKIADEFVS HHHHHHHHHHHHHHH | 30.73 | 17644757 | |
| 471 | Ubiquitination | LQDLVEYKGSKAKGV HHHHHHHCCCCCCCC | 43.11 | 17644757 | |
| 474 | Ubiquitination | LVEYKGSKAKGVNMA HHHHCCCCCCCCCHH | 63.89 | 17644757 | |
| 521 | Ubiquitination | KKGGKDSKRPQFGAD HCCCCCCCCCCCCCC | 77.54 | 17644757 | |
| 521 | Acetylation | KKGGKDSKRPQFGAD HCCCCCCCCCCCCCC | 77.54 | 24489116 | |
| 542 | Ubiquitination | AGIELLAKWKKEHGE HHHHHHHHHHHHHCC | 60.56 | 17644757 | |
| 591 | Phosphorylation | YDVDMEDSDDEKDNA EECCCCCCCCHHHCC | 33.39 | 22890988 | |
| 601 | Ubiquitination | EKDNAKGKESDSDLE HHHCCCCCCCCCCCC | 54.03 | 24961812 | |
| 603 | Phosphorylation | DNAKGKESDSDLELS HCCCCCCCCCCCCCC | 45.99 | 22890988 | |
| 605 | Phosphorylation | AKGKESDSDLELSDD CCCCCCCCCCCCCCC | 54.07 | 22890988 | |
| 610 | Phosphorylation | SDSDLELSDDDDEKE CCCCCCCCCCCCHHH | 29.62 | 22890988 | |
| 616 | Ubiquitination | LSDDDDEKEVKDEQE CCCCCCHHHHHHHHH | 74.85 | 24961812 | |
| 649 | Ubiquitination | LTPADFAKLQELRNE CCHHHHHHHHHHCCH | 51.18 | 24961812 | |
| 649 | Acetylation | LTPADFAKLQELRNE CCHHHHHHHHHHCCH | 51.18 | 24489116 | |
| 670 | Acetylation | MGIHKQDKREELVDA HCCCCCCCHHHHCCH | 60.25 | 24489116 | |
| 679 | Phosphorylation | EELVDASTLTGPIKY HHHCCHHHHCCCCCC | 30.02 | 28889911 | |
| 685 | Acetylation | STLTGPIKYKQSREE HHHCCCCCCCCCHHH | 49.91 | 24489116 | |
| 696 | Acetylation | SREERLQKVLEGREG CHHHHHHHHHHCCCC | 54.07 | 22865919 | |
| 734 | Phosphorylation | RRKNFVMSIHKRSVR HHHHHHHHHHHHHHC | 19.08 | 30377154 | |
| 745 | Acetylation | RSVRGKQKMSLRDKQ HHHCCCCCCCHHHHH | 33.66 | 25381059 | |
| 747 | Phosphorylation | VRGKQKMSLRDKQKV HCCCCCCCHHHHHHH | 27.56 | 25005228 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SDA1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SDA1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SDA1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-278, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-278, AND MASSSPECTROMETRY. | |
