| UniProt ID | KAPC_YEAST | |
|---|---|---|
| UniProt AC | P05986 | |
| Protein Name | cAMP-dependent protein kinase type 3 | |
| Gene Name | TPK3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 398 | |
| Subcellular Localization | ||
| Protein Description | ||
| Protein Sequence | MYVDPMNNNEIRKLSITAKTETTPDNVGQDIPVNAHSVHEECSSNTPVEINGRNSGKLKEEASAGICLVKKPMLQYRDTSGKYSLSDFQILRTLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTNDERRMLSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLAGYTPFYNSNTMKTYENILNAELKFPPFFHPDAQDLLKKLITRDLSERLGNLQNGSEDVKNHPWFNEVIWEKLLARYIETPYEPPIQQGQGDTSQFDRYPEEEFNYGIQGEDPYMDLMKEF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MYVDPMNNN ------CCCCCCCHH | 17.35 | 28132839 | |
| 15 | Phosphorylation | NNEIRKLSITAKTET HHHEEEEEEEEECCC | 22.41 | 19823750 | |
| 17 | Phosphorylation | EIRKLSITAKTETTP HEEEEEEEEECCCCC | 20.80 | 22890988 | |
| 20 | Phosphorylation | KLSITAKTETTPDNV EEEEEEECCCCCCCC | 35.78 | 19779198 | |
| 22 | Phosphorylation | SITAKTETTPDNVGQ EEEEECCCCCCCCCC | 49.19 | 21440633 | |
| 23 | Phosphorylation | ITAKTETTPDNVGQD EEEECCCCCCCCCCC | 23.55 | 21082442 | |
| 37 | Phosphorylation | DIPVNAHSVHEECSS CCCCCCCCCCHHHHC | 23.82 | 20377248 | |
| 43 | Phosphorylation | HSVHEECSSNTPVEI CCCCHHHHCCCCEEE | 29.87 | 19779198 | |
| 44 | Phosphorylation | SVHEECSSNTPVEIN CCCHHHHCCCCEEEC | 57.28 | 21440633 | |
| 46 | Phosphorylation | HEECSSNTPVEINGR CHHHHCCCCEEECCC | 30.57 | 20377248 | |
| 55 | Phosphorylation | VEINGRNSGKLKEEA EEECCCCCCCCCCCE | 35.62 | 20377248 | |
| 82 | Acetylation | QYRDTSGKYSLSDFQ EEECCCCCCCCCHHH | 31.28 | 24489116 | |
| 96 | Phosphorylation | QILRTLGTGSFGRVH HHHHHHCCCCCCEEE | 32.53 | 22369663 | |
| 98 | Phosphorylation | LRTLGTGSFGRVHLI HHHHCCCCCCEEEEE | 25.10 | 22369663 | |
| 213 | Ubiquitination | DIIYRDLKPENILLD CCCCCCCCHHHEEEC | 55.35 | 23749301 | |
| 221 | Acetylation | PENILLDKNGHIKIT HHHEEECCCCCEEEC | 65.87 | 24489116 | |
| 235 | Phosphorylation | TDFGFAKYVPDVTYT CCCCCCCCCCCCEEE | 17.49 | 22369663 | |
| 240 | Phosphorylation | AKYVPDVTYTLCGTP CCCCCCCEEEECCCC | 20.40 | 22369663 | |
| 241 | Phosphorylation | KYVPDVTYTLCGTPD CCCCCCEEEECCCCC | 9.50 | 20377248 | |
| 242 | Phosphorylation | YVPDVTYTLCGTPDY CCCCCEEEECCCCCC | 13.25 | 22369663 | |
| 246 | Phosphorylation | VTYTLCGTPDYIAPE CEEEECCCCCCCCCC | 16.40 | 22369663 | |
| 323 | Phosphorylation | KLITRDLSERLGNLQ HHHHHHHHHHHCCCC | 25.59 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KAPC_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KAPC_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KAPC_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-37, AND MASSSPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15, AND MASSSPECTROMETRY. | |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-23, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-242, AND MASSSPECTROMETRY. | |
