GPB2_YEAST - dbPTM
GPB2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GPB2_YEAST
UniProt AC P39717
Protein Name Guanine nucleotide-binding protein subunit beta 2
Gene Name GPB2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 880
Subcellular Localization Cytoplasm . Mitochondrion .
Protein Description Beta subunit of a guanine nucleotide-binding protein (G protein). G proteins are involved as modulators or transducers in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Involved in the determination of the cAMP level according to nutritional conditions, most probably as a regulator of cAMP phosphodiesterase. Required for the control of pseudohyphal and haploid invasive growth..
Protein Sequence MEISSSPWNDGGYSPYERNRVAVSPFSSALEGEERIETSRSLGDHCFEPLPYVTNYLSIFALFGKEIFGDKGNVSSRNEYLLKKYYSLKKPFVLRHNGHALKNPDMPLQRNDILQTNFMVDKFLNRTVRSVNFNNFKIISDMQSKSGRGTKSGTNQNQSADAIQNICLPSIPSALPYFQYYRKLLTVNTKEWDILKLHSLWVPKLRKDFKDFSLYGDKNSLKPIDSHYDEDNTMKKNLFFERSPSRQTLDGKGCASKGYDISSGNMIIPSLFSEDKLPALTYHCSVELNGNIYIFGGLMPCYSYEEDAPMLNDFFVDGIKNLPPPLLPQVINNPSMVNNPHLYVASIPSCRFSKPKMGGYIPPPLLCVQGSKLTDRHIFFYGGFEIRTETRGDENGKYHLKKRLYVNNTGYILDIMSFKFTKIDIIVQPSKYNAYPTMSSRFGHLQISIDNPNRRASVHSSSMNEIHKMGSASMKQGSSITSGRLEKAAVLSSLPHNTVHTVIIFGGYRQTGDDRYEAMNDLWKIEIPVIRRGKKGYCKFSETANAILLTPSEKDKSDWPEERAFSAFSVHGTSLMDRSSLDMRLLNNLKNHFVLKPSYISQDRVVSPKPVFPMMVHGTHQDLFNSGSAAQESPKAGASASSASAASFDPDMDDNLENYIVNPGRKSSSIPMTAIGRQRLILSQEKPVGKTVVLHGGSNGLNVLDDMWLMDLECETWTPIETFAKADSSEDGDEKLDSVNVGLVGHRMESIGRICVCIGGMVQEDVDQFYSENDDEPPRKRKVDTLPLGGNFLNTIDLSTQCWEEHKITLSKKEDDEDRQDSENEDTNSNIVVGVGGTSLQCDKSIILIGGLISRRSNVKEIYLHGTITKSIFPSVNPSA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
24PhosphorylationERNRVAVSPFSSALE
CCCCEEECCCCHHHC		15.5322369663
27PhosphorylationRVAVSPFSSALEGEE
CEEECCCCHHHCCHH		20.3422369663
28PhosphorylationVAVSPFSSALEGEER
EEECCCCHHHCCHHH		36.9322369663
213PhosphorylationRKDFKDFSLYGDKNS
CCCCCCCCCCCCCCC		30.7119779198
215PhosphorylationDFKDFSLYGDKNSLK
CCCCCCCCCCCCCCC		23.2919779198
233PhosphorylationSHYDEDNTMKKNLFF
CCCCCCCCCCCCEEE		42.5619779198
243PhosphorylationKNLFFERSPSRQTLD
CCEEEECCCCCCCCC		21.7421440633
245PhosphorylationLFFERSPSRQTLDGK
EEEECCCCCCCCCCC		37.9621440633
248PhosphorylationERSPSRQTLDGKGCA
ECCCCCCCCCCCCCC		26.2121440633
457PhosphorylationDNPNRRASVHSSSMN
CCCCCCEECCCCCHH		20.6728889911
461PhosphorylationRRASVHSSSMNEIHK
CCEECCCCCHHHHHH		20.8027017623
473PhosphorylationIHKMGSASMKQGSSI
HHHHCCCHHCCCCCC		28.3627017623
481PhosphorylationMKQGSSITSGRLEKA
HCCCCCCCCCHHHHH		27.3827017623
482PhosphorylationKQGSSITSGRLEKAA
CCCCCCCCCHHHHHH		21.9027017623
601PhosphorylationVLKPSYISQDRVVSP
EECHHHCCCCCCCCC		20.1427717283
607PhosphorylationISQDRVVSPKPVFPM
CCCCCCCCCCCCCCE		25.0921551504
628PhosphorylationQDLFNSGSAAQESPK
HHHHHCCCCCCCCCC		21.9124961812
633PhosphorylationSGSAAQESPKAGASA
CCCCCCCCCCCCCCC		21.4420377248
644PhosphorylationGASASSASAASFDPD
CCCCCCHHHHHCCCC		26.7321551504
647PhosphorylationASSASAASFDPDMDD
CCCHHHHHCCCCCCC		29.8721551504
668PhosphorylationVNPGRKSSSIPMTAI
CCCCCCCCCCCCCHH		35.0123749301
669PhosphorylationNPGRKSSSIPMTAIG
CCCCCCCCCCCCHHC		37.4919779198
673PhosphorylationKSSSIPMTAIGRQRL
CCCCCCCCHHCCCEE		15.1228889911
686UbiquitinationRLILSQEKPVGKTVV
EEEEECCCCCCCEEE		37.0523749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GPB2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GPB2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GPB2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GPB1_YEASTGPB1genetic
12538771
IRA1_YEASTIRA1physical
16793550
IRA2_YEASTIRA2physical
16793550
VAC17_YEASTVAC17genetic
20093466
MRC1_YEASTMRC1genetic
20093466
PEX34_YEASTPEX34genetic
20093466
GFD2_YEASTGFD2genetic
20093466
MXR2_YEASTMXR2genetic
20093466
STE50_YEASTSTE50genetic
20093466
RHEB_YEASTRHB1genetic
20093466
BUD31_YEASTBUD31genetic
20093466
UBP3_YEASTUBP3genetic
20093466
RIM15_YEASTRIM15genetic
20093466
PCP1_YEASTPCP1genetic
20093466
YOR1_YEASTYOR1genetic
20093466
SODM_YEASTSOD2genetic
20093466
RS27B_YEASTRPS27Bgenetic
20093466
LRP1_YEASTLRP1genetic
20093466
STB5_YEASTSTB5genetic
20093466
NFU1_YEASTNFU1genetic
20093466
MRT4_YEASTMRT4genetic
20093466
RS22B_YEASTRPS22Bgenetic
20093466
MSC1_YEASTMSC1genetic
20093466
COG5_YEASTCOG5genetic
20093466
ENG1_YEASTDSE4genetic
20093466
IRA2_YEASTIRA2genetic
20093466
IDH2_YEASTIDH2genetic
20093466
GPB1_YEASTGPB1genetic
20093466
QCR2_YEASTQCR2genetic
20093466
KAPR_YEASTBCY1genetic
20826609
TBP7_YEASTYTA7genetic
27708008
DIA2_YEASTDIA2genetic
27708008
STE50_YEASTSTE50genetic
27708008
MXR2_YEASTMXR2genetic
27708008
GFD2_YEASTGFD2genetic
27708008
PEX34_YEASTPEX34genetic
27708008
VAC17_YEASTVAC17genetic
27708008
LSM6_YEASTLSM6genetic
27708008
YOR1_YEASTYOR1genetic
27708008
LRP1_YEASTLRP1genetic
27708008
STB5_YEASTSTB5genetic
27708008
DAL81_YEASTDAL81genetic
27708008
MRT4_YEASTMRT4genetic
27708008
YL049_YEASTYLR049Cgenetic
27708008
SEC72_YEASTSEC72genetic
27708008
UBX2_YEASTUBX2genetic
27708008
COG5_YEASTCOG5genetic
27708008
EAF7_YEASTEAF7genetic
27708008
LSM7_YEASTLSM7genetic
27708008
ENG1_YEASTDSE4genetic
27708008
IRA2_YEASTIRA2genetic
27708008
IDH2_YEASTIDH2genetic
27708008
ISN1_YEASTISN1genetic
27708008
GPB1_YEASTGPB1genetic
27708008
QCR2_YEASTQCR2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GPB2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, AND MASSSPECTROMETRY.

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