YL049_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YL049_YEAST
• UniProt AC: Q12110
• Protein Name: Uncharacterized protein YLR049C
• Gene Name: YLR049C
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 428
• Protein Sequence: MVNNIMHEYVPPSQRLFHSRHRITRNDLKEEALHSGTTDWTTILDTTIDKDTNLISYAVPIIDNFAIPRANSQGSPVAPSPNHRSTMYSSSSSSASSVFSDGLFTPNNNRNSSGSSSLVIRPQKNLSVDSLIQENKRKINSEKESLSLIANNNDETLCTHTDPSIQNLIKSETKRNILNLKFQNRNLFRRELKLEKFWSNLRSCHTSGDETDLLLVISKHNLYWFGIPNDFRLPIYKRCLYHYSELDEAGFFSQYANNSLYLAIRKCCNNEEQETLSRSIFINLTKNVTWLNSRFDDNKDNKNSYTVTEGKFYQDFPNLYYHLKDKLKLNVIMDFIKPVIRNFMTNALNKHKLDGIGLELLDILIVTTYYGPNKINAFLMDTFILNLLKQCHYKFFVSNISELVIQISKIDCDLVILLEDLRSRIDLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	Phosphorylation	FAIPRANSQGSPVAP CCCCCCCCCCCCCCC	34.63	23749301
75	Phosphorylation	PRANSQGSPVAPSPN CCCCCCCCCCCCCCC	14.47	23749301
80	Phosphorylation	QGSPVAPSPNHRSTM CCCCCCCCCCCCCCC	28.70	23749301
124	Ubiquitination	SLVIRPQKNLSVDSL CEEECCCCCCCHHHH	63.64	17644757
127	Phosphorylation	IRPQKNLSVDSLIQE ECCCCCCCHHHHHHH	33.02	19823750
130	Phosphorylation	QKNLSVDSLIQENKR CCCCCHHHHHHHCHH	25.80	22890988
136	Ubiquitination	DSLIQENKRKINSEK HHHHHHCHHHHCCCH	55.08	23749301
138	Ubiquitination	LIQENKRKINSEKES HHHHCHHHHCCCHHH	48.09	17644757
143	Ubiquitination	KRKINSEKESLSLIA HHHHCCCHHHHHHHH	53.04	17644757
170	Ubiquitination	PSIQNLIKSETKRNI HHHHHHHHHHHHHHH	45.46	17644757
219	Ubiquitination	DLLLVISKHNLYWFG CEEEEEECCCEEEEC	25.95	17644757
266	Ubiquitination	SLYLAIRKCCNNEEQ HHHHHHHHHCCCHHH	36.71	23749301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YL049_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YL049_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YL049_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACS1_YEAST	ACS1	physical	11283351
YO214_YEAST	SPR2	genetic	20093466
AIM44_YEAST	AIM44	genetic	20093466

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127, AND MASSSPECTROMETRY.
PubMed: 15665377