ACS1_YEAST - dbPTM
ACS1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ACS1_YEAST
UniProt AC Q01574
Protein Name Acetyl-coenzyme A synthetase 1
Gene Name ACS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 713
Subcellular Localization Microsome . Cytoplasm. Mitochondrion. Nucleus.
Protein Description Catalyzes the production of acetyl-CoA. Provides the acetyl-CoA source for histone acetylation in the nucleus. "Aerobic" isozyme of acetyl-coenzyme A synthetase, which supports growth on nonfermentable carbon sources such as glycerol and ethanol. May be required for assimilation of ethanol and acetate..
Protein Sequence MSPSAVQSSKLEEQSSEIDKLKAKMSQSAATAQQKKEHEYEHLTSVKIVPQRPISDRLQPAIATHYSPHLDGLQDYQRLHKESIEDPAKFFGSKATQFLNWSKPFDKVFIPDPKTGRPSFQNNAWFLNGQLNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILRKILAGESDQLGDVSTLSNPGIVRHLIDSVKL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSPSAVQSS
------CCHHHHHCH		27.8025371407
4Phosphorylation----MSPSAVQSSKL
----CCHHHHHCHHH		33.4927214570
8PhosphorylationMSPSAVQSSKLEEQS
CCHHHHHCHHHHHHH		23.8830377154
15PhosphorylationSSKLEEQSSEIDKLK
CHHHHHHHHHHHHHH		32.9727214570
16PhosphorylationSKLEEQSSEIDKLKA
HHHHHHHHHHHHHHH		37.9627214570
20AcetylationEQSSEIDKLKAKMSQ
HHHHHHHHHHHHHHH		58.5125381059
22AcetylationSSEIDKLKAKMSQSA
HHHHHHHHHHHHHHH		52.2625381059
26PhosphorylationDKLKAKMSQSAATAQ
HHHHHHHHHHHHHHH		21.9230377154
31PhosphorylationKMSQSAATAQQKKEH
HHHHHHHHHHHHHHH		25.3924930733
35AcetylationSAATAQQKKEHEYEH
HHHHHHHHHHHHHHH		48.3125381059
45PhosphorylationHEYEHLTSVKIVPQR
HHHHHCCCCEEEECC		27.9827214570
55PhosphorylationIVPQRPISDRLQPAI
EEECCCCCCCCCHHH		21.2529734811
64PhosphorylationRLQPAIATHYSPHLD
CCCHHHHHCCCCCCC		18.4227214570
66PhosphorylationQPAIATHYSPHLDGL
CHHHHHCCCCCCCCH		21.3927214570
67PhosphorylationPAIATHYSPHLDGLQ
HHHHHCCCCCCCCHH		9.7629734811
191PhosphorylationMGVRKGDTVAVYMPM
CCCCCCCEEEEECCC		21.0219779198
195PhosphorylationKGDTVAVYMPMVPEA
CCCEEEEECCCCHHH		5.9319779198
266PhosphorylationVDDALRETPGVRHVL
CCHHHHHCCCCEEEE		20.9327214570
278PhosphorylationHVLVYRKTNNPSVAF
EEEEEECCCCCCEEE		31.0929136822
282PhosphorylationYRKTNNPSVAFHAPR
EECCCCCCEEEECCC		28.3527214570
307PhosphorylationYKTYYPCTPVDSEDP
CCCCCCCCCCCCCCC		23.1127214570
415PhosphorylationTQFYVAPTALRLLKR
CEEEEHHHHHHHHHH		28.6927214570
426PhosphorylationLLKRAGDSYIENHSL
HHHHHCCCHHHCCCC		27.3927214570
427PhosphorylationLKRAGDSYIENHSLK
HHHHCCCHHHCCCCC		19.5927214570
434AcetylationYIENHSLKSLRCLGS
HHHCCCCCCCEECCC		50.9225381059
565AcetylationGDGAAKDKDGYIWIL
CCCCCCCCCCEEEEE		52.9624489116
582PhosphorylationVDDVVNVSGHRLSTA
CCCEEECCCCCCCHH		24.5527214570
642AcetylationDDELQDIKKHLVFTV
HHHHHHHHHHHCEEE		42.2925381059
696PhosphorylationSDQLGDVSTLSNPGI
CCCCCCCHHCCCHHH		28.5027214570
697PhosphorylationDQLGDVSTLSNPGIV
CCCCCCHHCCCHHHH		33.7727214570
699PhosphorylationLGDVSTLSNPGIVRH
CCCCHHCCCHHHHHH		40.8627214570
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ACS1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ACS1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ACS1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CACM_YEASTYAT1physical
18467557
ADR1_YEASTADR1physical
18719252
ACS2_YEASTACS2genetic
19406923
ACS2_YEASTACS2genetic
16941010
THDH_YEASTILV1genetic
21623372
ETR1_YEASTETR1genetic
21623372
PFKA1_YEASTPFK1genetic
21623372
MET22_YEASTMET22genetic
21623372
THRC_YEASTTHR4genetic
21623372
POS5_YEASTPOS5genetic
21623372
DHOM_YEASTHOM6genetic
21623372
MET10_YEASTMET10genetic
21623372
FOLE_YEASTMET7genetic
21623372
ERG2_YEASTERG2genetic
21623372
EPT1_YEASTEPT1genetic
21623372
SCS7_YEASTSCS7genetic
21623372
ADH3_YEASTADH3genetic
21623372
CISY2_YEASTCIT2genetic
22876324
MASY_YEASTMLS1genetic
22876324
PDR3_YEASTPDR3genetic
27708008
TXTP_YEASTCTP1genetic
27708008
GID7_YEASTGID7genetic
27708008
ATG9_YEASTATG9genetic
27708008
CSK2B_YEASTCKB1genetic
27708008
NEM1_YEASTNEM1genetic
27708008
YHK5_YEASTYHR045Wgenetic
27708008
KSP1_YEASTKSP1genetic
27708008
PRY2_YEASTPRY2genetic
27708008
YL224_YEASTYLR224Wgenetic
27708008
ARV1_YEASTARV1genetic
27708008
VIP1_YEASTVIP1genetic
27708008
LSM7_YEASTLSM7genetic
27708008
MET22_YEASTMET22genetic
27708008
SFL1_YEASTSFL1genetic
27708008
ALDH6_YEASTALD6genetic
27708008
YP089_YEASTYPR089Wgenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ACS1_YEAST

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory