| UniProt ID | PFKA1_YEAST | |
|---|---|---|
| UniProt AC | P16861 | |
| Protein Name | ATP-dependent 6-phosphofructokinase subunit alpha {ECO:0000255|HAMAP-Rule:MF_03184} | |
| Gene Name | PFK1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 987 | |
| Subcellular Localization |
Cytoplasm . Mitochondrion outer membrane Peripheral membrane protein Cytoplasmic side . |
|
| Protein Description | Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.. | |
| Protein Sequence | MQSQDSCYGVAFRSIITNDEALFKKTIHFYHTLGFATVKDFNKFKHGENSLLSSGTSQDSLREVWLESFKLSEVDASGFRIPQQEATNKAQSQGALLKIRLVMSAPIDETFDTNETATITYFSTDLNKIVEKFPKQAEKLSDTLVFLKDPMGNNITFSGLANATDSAPTSKDAFLEATSEDEIISRASSDASDLLRQTLGSSQKKKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGKYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKREGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWPSLVDELVAEGRFTKEEVAPYKNLSIVGLVGSIDNDMSGTDSTIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPHGKWQDELKEVCQRHRSKGRRNNTIIVAEGALDDQLNPVTANDVKDALIELGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEFTPETPSPLIGILENKIIRMPLVESVKLTKSVATAIENKDFDKAISLRDTEFIELYENFLSTTVKDDGSELLPVSDRLNIGIVHVGAPSAALNAATRAATLYCLSHGHKPYAIMNGFSGLIQTGEVKELSWIDVENWHNLGGSEIGTNRSVASEDLGTIAYYFQKNKLDGLIILGGFEGFRSLKQLRDGRTQHPIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSASATRRRVFVCEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIREDITLLKENFRHDKGENRNGKLLVRNEQASSVYSTQLLADIISEASKGKFGVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQWNKKNEASPNTDAKVLRFKFDTHGEKVPTVEHEDDSAAVICVNGSHVSFKPIANLWENETNVELRKGFEVHWAEYNKIGDILSGRLKLRAEVAALAAENK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MQSQDSCYGV -----CCCCCCCCHH | 25752575 | ||
| 6 | Phosphorylation | --MQSQDSCYGVAFR --CCCCCCCCHHHHH | 28152593 | ||
| 8 | Phosphorylation | MQSQDSCYGVAFRSI CCCCCCCCHHHHHHH | 30377154 | ||
| 24 | Acetylation | TNDEALFKKTIHFYH CCCHHHHHHHHHHHH | 24489116 | ||
| 24 | Succinylation | TNDEALFKKTIHFYH CCCHHHHHHHHHHHH | 23954790 | ||
| 24 | Ubiquitination | TNDEALFKKTIHFYH CCCHHHHHHHHHHHH | 15699485 | ||
| 25 | Ubiquitination | NDEALFKKTIHFYHT CCHHHHHHHHHHHHH | 15699485 | ||
| 45 | Acetylation | VKDFNKFKHGENSLL HHCCCCCCCCCCCCC | 24489116 | ||
| 50 | Phosphorylation | KFKHGENSLLSSGTS CCCCCCCCCCCCCCC | 25752575 | ||
| 53 | Phosphorylation | HGENSLLSSGTSQDS CCCCCCCCCCCCHHH | 24961812 | ||
| 54 | Phosphorylation | GENSLLSSGTSQDSL CCCCCCCCCCCHHHH | 24961812 | ||
| 56 | Phosphorylation | NSLLSSGTSQDSLRE CCCCCCCCCHHHHHH | 30377154 | ||
| 57 | Phosphorylation | SLLSSGTSQDSLREV CCCCCCCCHHHHHHH | 23749301 | ||
| 70 | Ubiquitination | EVWLESFKLSEVDAS HHHHHHCCCCEECCC | 17644757 | ||
| 77 | Phosphorylation | KLSEVDASGFRIPQQ CCCEECCCCCCCCHH | 23749301 | ||
| 89 | Acetylation | PQQEATNKAQSQGAL CHHHHCCHHHHHHHH | 24489116 | ||
| 89 | Ubiquitination | PQQEATNKAQSQGAL CHHHHCCHHHHHHHH | 23749301 | ||
| 92 | Phosphorylation | EATNKAQSQGALLKI HHCCHHHHHHHHHHE | 22369663 | ||
| 98 | 2-Hydroxyisobutyrylation | QSQGALLKIRLVMSA HHHHHHHHEEEEEEC | - | ||
| 132 | 2-Hydroxyisobutyrylation | DLNKIVEKFPKQAEK CHHHHHHHCHHHHHH | - | ||
| 132 | Acetylation | DLNKIVEKFPKQAEK CHHHHHHHCHHHHHH | 24489116 | ||
| 139 | Acetylation | KFPKQAEKLSDTLVF HCHHHHHHHCCEEEE | 24489116 | ||
| 156 | Phosphorylation | DPMGNNITFSGLANA CCCCCCCEEECCCCC | 22369663 | ||
| 158 | Phosphorylation | MGNNITFSGLANATD CCCCCEEECCCCCCC | 22369663 | ||
| 164 | Phosphorylation | FSGLANATDSAPTSK EECCCCCCCCCCCCH | 22369663 | ||
| 166 | Phosphorylation | GLANATDSAPTSKDA CCCCCCCCCCCCHHH | 22369663 | ||
| 169 | Phosphorylation | NATDSAPTSKDAFLE CCCCCCCCCHHHHHH | 22369663 | ||
| 170 | Phosphorylation | ATDSAPTSKDAFLEA CCCCCCCCHHHHHHC | 22369663 | ||
| 178 | Phosphorylation | KDAFLEATSEDEIIS HHHHHHCCCHHHHHH | 22369663 | ||
| 179 | Phosphorylation | DAFLEATSEDEIISR HHHHHCCCHHHHHHH | 22369663 | ||
| 185 | Phosphorylation | TSEDEIISRASSDAS CCHHHHHHHHCCCHH | 22369663 | ||
| 188 | Phosphorylation | DEIISRASSDASDLL HHHHHHHCCCHHHHH | 22369663 | ||
| 189 | Phosphorylation | EIISRASSDASDLLR HHHHHHCCCHHHHHH | 22369663 | ||
| 192 | Phosphorylation | SRASSDASDLLRQTL HHHCCCHHHHHHHHH | 22369663 | ||
| 198 | Phosphorylation | ASDLLRQTLGSSQKK HHHHHHHHHCCCCCC | 21440633 | ||
| 201 | Phosphorylation | LLRQTLGSSQKKKKI HHHHHHCCCCCCCEE | 22369663 | ||
| 202 | Phosphorylation | LRQTLGSSQKKKKIA HHHHHCCCCCCCEEE | 22369663 | ||
| 204 | Ubiquitination | QTLGSSQKKKKIAVM HHHCCCCCCCEEEEE | 24961812 | ||
| 207 | Ubiquitination | GSSQKKKKIAVMTSG CCCCCCCEEEEEECC | 23749301 | ||
| 217 | Phosphorylation | VMTSGGDSPGMNAAV EEECCCCCHHHHHHH | 28152593 | ||
| 268 | Phosphorylation | EDVRGWLSEGGTLIG HHHHHHHHCCCEEEE | 19779198 | ||
| 337 | Acetylation | VAEGRFTKEEVAPYK HHCCCCCHHHCCCCC | 24489116 | ||
| 337 | Succinylation | VAEGRFTKEEVAPYK HHCCCCCHHHCCCCC | 23954790 | ||
| 337 | Ubiquitination | VAEGRFTKEEVAPYK HHCCCCCHHHCCCCC | 23749301 | ||
| 344 | Ubiquitination | KEEVAPYKNLSIVGL HHHCCCCCCCEEEEE | 17644757 | ||
| 387 | Ubiquitination | DYIDATAKSHSRAFV HHHHHHCHHCCCEEH | 23749301 | ||
| 429 | Acetylation | ERAVPHGKWQDELKE CCCCCCCCCHHHHHH | 24489116 | ||
| 435 | Acetylation | GKWQDELKEVCQRHR CCCHHHHHHHHHHHH | 24489116 | ||
| 450 | Phosphorylation | SKGRRNNTIIVAEGA HCCCCCCEEEEECCC | 28889911 | ||
| 482 | Ubiquitination | IELGLDTKVTILGHV HHCCCCCEEEEEEEH | 17644757 | ||
| 494 | Phosphorylation | GHVQRGGTAVAHDRW EEHHCCCEEEECCHH | 28889911 | ||
| 512 | Ubiquitination | LQGVDAVKAVLEFTP HCCHHHHHHHHHCCC | 17644757 | ||
| 518 | Phosphorylation | VKAVLEFTPETPSPL HHHHHHCCCCCCCCC | 22369663 | ||
| 521 | Phosphorylation | VLEFTPETPSPLIGI HHHCCCCCCCCCEEH | 22369663 | ||
| 523 | Phosphorylation | EFTPETPSPLIGILE HCCCCCCCCCEEHHH | 21440633 | ||
| 532 | Ubiquitination | LIGILENKIIRMPLV CEEHHHCCEEECHHH | 23749301 | ||
| 543 | 2-Hydroxyisobutyrylation | MPLVESVKLTKSVAT CHHHCCHHCCHHHHH | - | ||
| 543 | Acetylation | MPLVESVKLTKSVAT CHHHCCHHCCHHHHH | 24489116 | ||
| 546 | 2-Hydroxyisobutyrylation | VESVKLTKSVATAIE HCCHHCCHHHHHHHH | - | ||
| 546 | Acetylation | VESVKLTKSVATAIE HCCHHCCHHHHHHHH | 22865919 | ||
| 546 | Ubiquitination | VESVKLTKSVATAIE HCCHHCCHHHHHHHH | 17644757 | ||
| 547 | Phosphorylation | ESVKLTKSVATAIEN CCHHCCHHHHHHHHC | 22369663 | ||
| 555 | 2-Hydroxyisobutyrylation | VATAIENKDFDKAIS HHHHHHCCCHHHHHC | - | ||
| 555 | Acetylation | VATAIENKDFDKAIS HHHHHHCCCHHHHHC | 24489116 | ||
| 555 | Succinylation | VATAIENKDFDKAIS HHHHHHCCCHHHHHC | 23954790 | ||
| 555 | Ubiquitination | VATAIENKDFDKAIS HHHHHHCCCHHHHHC | 22817900 | ||
| 559 | 2-Hydroxyisobutyrylation | IENKDFDKAISLRDT HHCCCHHHHHCCCCH | - | ||
| 559 | Acetylation | IENKDFDKAISLRDT HHCCCHHHHHCCCCH | 24489116 | ||
| 559 | Ubiquitination | IENKDFDKAISLRDT HHCCCHHHHHCCCCH | 23749301 | ||
| 585 | Phosphorylation | TTVKDDGSELLPVSD CEECCCCCCEEECHH | 22369663 | ||
| 591 | Phosphorylation | GSELLPVSDRLNIGI CCCEEECHHCEEEEE | 22369663 | ||
| 605 | Phosphorylation | IVHVGAPSAALNAAT EEEECCHHHHHHHHH | 22369663 | ||
| 612 | Phosphorylation | SAALNAATRAATLYC HHHHHHHHHHHHHHH | 22369663 | ||
| 625 | Acetylation | YCLSHGHKPYAIMNG HHHHCCCCCEEEECC | 24489116 | ||
| 625 | Ubiquitination | YCLSHGHKPYAIMNG HHHHCCCCCEEEECC | 22106047 | ||
| 643 | Ubiquitination | LIQTGEVKELSWIDV EEECCCCEEEEEEEC | 17644757 | ||
| 666 | Phosphorylation | SEIGTNRSVASEDLG CCCCCCCCHHCCCHH | 27017623 | ||
| 681 | Acetylation | TIAYYFQKNKLDGLI HHHHHHHHCCCCEEE | 24489116 | ||
| 681 | Ubiquitination | TIAYYFQKNKLDGLI HHHHHHHHCCCCEEE | 17644757 | ||
| 683 | Acetylation | AYYFQKNKLDGLIIL HHHHHHCCCCEEEEE | 24489116 | ||
| 683 | Ubiquitination | AYYFQKNKLDGLIIL HHHHHHCCCCEEEEE | 17644757 | ||
| 807 | Acetylation | REDITLLKENFRHDK HHHHHHHHHHCCCCC | 24489116 | ||
| 807 | Succinylation | REDITLLKENFRHDK HHHHHHHHHHCCCCC | 23954790 | ||
| 807 | Ubiquitination | REDITLLKENFRHDK HHHHHHHHHHCCCCC | 24961812 | ||
| 814 | Acetylation | KENFRHDKGENRNGK HHHCCCCCCCCCCCC | 24489116 | ||
| 821 | Ubiquitination | KGENRNGKLLVRNEQ CCCCCCCCEEECCHH | 23749301 | ||
| 830 | Phosphorylation | LVRNEQASSVYSTQL EECCHHHCCHHHHHH | 23749301 | ||
| 831 | Phosphorylation | VRNEQASSVYSTQLL ECCHHHCCHHHHHHH | 22369663 | ||
| 833 | Phosphorylation | NEQASSVYSTQLLAD CHHHCCHHHHHHHHH | 22369663 | ||
| 834 | Phosphorylation | EQASSVYSTQLLADI HHHCCHHHHHHHHHH | 22369663 | ||
| 835 | Phosphorylation | QASSVYSTQLLADII HHCCHHHHHHHHHHH | 22369663 | ||
| 843 | Phosphorylation | QLLADIISEASKGKF HHHHHHHHHHHCCCC | 22369663 | ||
| 846 | Phosphorylation | ADIISEASKGKFGVR HHHHHHHHCCCCCCC | 22369663 | ||
| 847 | Ubiquitination | DIISEASKGKFGVRT HHHHHHHCCCCCCCC | 17644757 | ||
| 869 | Succinylation | QGGVPSSKDRVTASR CCCCCCCCHHHHHHH | 23954790 | ||
| 869 | Ubiquitination | QGGVPSSKDRVTASR CCCCCCCCHHHHHHH | 17644757 | ||
| 880 | Acetylation | TASRFAVKCIKFIEQ HHHHHHHHHHHHHHH | 25381059 | ||
| 880 | Ubiquitination | TASRFAVKCIKFIEQ HHHHHHHHHHHHHHH | 22817900 | ||
| 883 | Acetylation | RFAVKCIKFIEQWNK HHHHHHHHHHHHHHH | 24489116 | ||
| 883 | Ubiquitination | RFAVKCIKFIEQWNK HHHHHHHHHHHHHHH | 22817900 | ||
| 890 | Acetylation | KFIEQWNKKNEASPN HHHHHHHHCCCCCCC | 22865919 | ||
| 891 | Acetylation | FIEQWNKKNEASPNT HHHHHHHCCCCCCCC | 24489116 | ||
| 891 | Ubiquitination | FIEQWNKKNEASPNT HHHHHHHCCCCCCCC | 24961812 | ||
| 895 | Phosphorylation | WNKKNEASPNTDAKV HHHCCCCCCCCCCCE | 25521595 | ||
| 898 | Phosphorylation | KNEASPNTDAKVLRF CCCCCCCCCCCEEEE | 25521595 | ||
| 901 | Acetylation | ASPNTDAKVLRFKFD CCCCCCCCEEEEEEE | 22865919 | ||
| 901 | Ubiquitination | ASPNTDAKVLRFKFD CCCCCCCCEEEEEEE | 23749301 | ||
| 906 | Acetylation | DAKVLRFKFDTHGEK CCCEEEEEEECCCCC | 24489116 | ||
| 953 | Ubiquitination | ETNVELRKGFEVHWA CCCCEECCCCEEEEE | 22817900 | ||
| 974 | Ubiquitination | DILSGRLKLRAEVAA HHHCCHHHHHHHHHH | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PFKA1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PFKA1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PFKA1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
