| UniProt ID | FUMH_YEAST | |
|---|---|---|
| UniProt AC | P08417 | |
| Protein Name | Fumarate hydratase, mitochondrial | |
| Gene Name | FUM1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 488 | |
| Subcellular Localization | Mitochondrion matrix . Cytoplasm . Both fumarases are encoded by a single nuclear gene. | |
| Protein Description | ||
| Protein Sequence | MLRFTNCSCKTFVKSSYKLNIRRMNSSFRTETDAFGEIHVPADKYWGAQTQRSFQNFKIGGARERMPLPLVHAFGVLKKSAAIVNESLGGLDPKISKAIQQAADEVASGKLDDHFPLVVFQTGSGTQSNMNANEVISNRAIEILGGKIGSKQVHPNNHCNQSQSSNDTFPTVMHIAASLQIQNELIPELTNLKNALEAKSKEFDHIVKIGRTHLQDATPLTLGQEFSGYVQQVENGIQRVAHSLKTLSFLAQGGTAVGTGLNTKPGFDVKIAEQISKETGLKFQTAPNKFEALAAHDAIVECSGALNTLACSLFKIAQDIRYLGSGPRCGYHELMLPENEPGSSIMPGKVNPTQNEALTQVCVQVMGNNAAITFAGSQGQFELNVFKPVMIANLLNSIRLITDAAYSFRVHCVEGIKANEPRIHELLTKSLMLVTALNPKIGYDAASKVAKNAHKKGITLKESALELGVLTEKEFDEWVVPEHMLGPK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Acetylation | RFTNCSCKTFVKSSY CCCCCCCHHHHCHHH | 28.80 | 25381059 | |
| 44 | Acetylation | EIHVPADKYWGAQTQ CEECCHHHHCCCCCH | 45.04 | 24489116 | |
| 58 | Succinylation | QRSFQNFKIGGARER HHHHCCCEECCCHHC | 48.25 | 23954790 | |
| 58 | Acetylation | QRSFQNFKIGGARER HHHHCCCEECCCHHC | 48.25 | 24489116 | |
| 94 | Acetylation | SLGGLDPKISKAIQQ HCCCCCHHHHHHHHH | 60.31 | 24489116 | |
| 122 | Phosphorylation | FPLVVFQTGSGTQSN CCEEEEECCCCCCCC | 23.11 | 22369663 | |
| 124 | Phosphorylation | LVVFQTGSGTQSNMN EEEEECCCCCCCCCC | 41.89 | 22369663 | |
| 126 | Phosphorylation | VFQTGSGTQSNMNAN EEECCCCCCCCCCHH | 30.44 | 22369663 | |
| 128 | Phosphorylation | QTGSGTQSNMNANEV ECCCCCCCCCCHHHH | 37.57 | 22369663 | |
| 147 | Acetylation | AIEILGGKIGSKQVH HHHHHCCEECCEECC | 41.94 | 24489116 | |
| 199 | 2-Hydroxyisobutyrylation | LKNALEAKSKEFDHI HHHHHHHHHHHCHHH | 53.32 | - | |
| 208 | Acetylation | KEFDHIVKIGRTHLQ HHCHHHEEECCCCCC | 38.55 | 22865919 | |
| 245 | Acetylation | QRVAHSLKTLSFLAQ HHHHHHHHHHHHHHC | 50.89 | 24489116 | |
| 277 | 2-Hydroxyisobutyrylation | KIAEQISKETGLKFQ HHHHHHHHHHCCCCC | 62.01 | - | |
| 277 | Acetylation | KIAEQISKETGLKFQ HHHHHHHHHHCCCCC | 62.01 | 24489116 | |
| 417 | Acetylation | VHCVEGIKANEPRIH EEEHHHCCCCCHHHH | 56.89 | 25381059 | |
| 428 | Phosphorylation | PRIHELLTKSLMLVT HHHHHHHHHHHHHHH | 31.08 | 28889911 | |
| 440 | Acetylation | LVTALNPKIGYDAAS HHHHHCCCCCHHHHH | 47.92 | 24489116 | |
| 448 | 2-Hydroxyisobutyrylation | IGYDAASKVAKNAHK CCHHHHHHHHHHHHH | 41.29 | - | |
| 448 | Ubiquitination | IGYDAASKVAKNAHK CCHHHHHHHHHHHHH | 41.29 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FUMH_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FUMH_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FUMH_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Profiling phosphoproteins of yeast mitochondria reveals a role ofphosphorylation in assembly of the ATP synthase."; Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B.,van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.; Mol. Cell. Proteomics 6:1896-1906(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-428, AND MASSSPECTROMETRY. | |
