ACON_YEAST - dbPTM
ACON_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ACON_YEAST
UniProt AC P19414
Protein Name Aconitate hydratase, mitochondrial
Gene Name ACO1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 778
Subcellular Localization Mitochondrion. Cytoplasm. Mainly mitochondrial, small amounts are also detected in the cytosol with a ratio of 94:6.
Protein Description Catalyzes the isomerization of citrate to isocitrate via cis-aconitate, a step in the citric acid cycle. Can also provide minor contributions to the reversible dehydration of (R)-homocitrate to cis-homoaconitate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. Plays also an essential role in mtDNA maintenance. May directly protect mtDNA from accumulation of point mutations and ssDNA breaks as a component of mitochondrial nucleoids, or by preventing accumulation of iron citrate thereby alleviating its detrimental effects in mitochondria..
Protein Sequence MLSARSAIKRPIVRGLATVSNLTRDSKVNQNLLEDHSFINYKQNVETLDIVRKRLNRPFTYAEKILYGHLDDPHGQDIQRGVSYLKLRPDRVACQDATAQMAILQFMSAGLPQVAKPVTVHCDHLIQAQVGGEKDLKRAIDLNKEVYDFLASATAKYNMGFWKPGSGIIHQIVLENYAFPGALIIGTDSHTPNAGGLGQLAIGVGGADAVDVMAGRPWELKAPKILGVKLTGKMNGWTSPKDIILKLAGITTVKGGTGKIVEYFGDGVDTFSATGMGTICNMGAEIGATTSVFPFNKSMIEYLEATGRGKIADFAKLYHKDLLSADKDAEYDEVVEIDLNTLEPYINGPFTPDLATPVSKMKEVAVANNWPLDVRVGLIGSCTNSSYEDMSRSASIVKDAAAHGLKSKTIFTVTPGSEQIRATIERDGQLETFKEFGGIVLANACGPCIGQWDRRDIKKGDKNTIVSSYNRNFTSRNDGNPQTHAFVASPELVTAFAIAGDLRFNPLTDKLKDKDGNEFMLKPPHGDGLPQRGYDAGENTYQAPPADRSTVEVKVSPTSDRLQLLKPFKPWDGKDAKDMPILIKAVGKTTTDHISMAGPWLKYRGHLENISNNYMIGAINAENKKANCVKNVYTGEYKGVPDTARDYRDQGIKWVVIGDENFGEGSSREHAALEPRFLGGFAIITKSFARIHETNLKKQGLLPLNFKNPADYDKINPDDRIDILGLAELAPGKPVTMRVHPKNGKPWDAVLTHTFNDEQIEWFKYGSALNKIKADEKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
9AcetylationLSARSAIKRPIVRGL
CCHHHHCCCHHHHHH
52.4125381059
27AcetylationSNLTRDSKVNQNLLE
HHHCCCCCCCHHHHH
49.8724489116
37PhosphorylationQNLLEDHSFINYKQN
HHHHHCCCCCCHHCC
39.8921440633
41PhosphorylationEDHSFINYKQNVETL
HCCCCCCHHCCCHHH
14.7727017623
42AcetylationDHSFINYKQNVETLD
CCCCCCHHCCCHHHH
30.7924489116
47PhosphorylationNYKQNVETLDIVRKR
CHHCCCHHHHHHHHH
26.0027017623
83PhosphorylationQDIQRGVSYLKLRPD
CCCHHCCCEEECCCC
27.8020377248
86AcetylationQRGVSYLKLRPDRVA
HHCCCEEECCCCCCC
33.9324489116
144AcetylationKRAIDLNKEVYDFLA
HHHHHCCHHHHHHHH
56.7224489116
2242-HydroxyisobutyrylationPWELKAPKILGVKLT
CCCCCCCEEEEEECC
56.26-
2292-HydroxyisobutyrylationAPKILGVKLTGKMNG
CCEEEEEECCCCCCC
38.23-
229AcetylationAPKILGVKLTGKMNG
CCEEEEEECCCCCCC
38.2324489116
239PhosphorylationGKMNGWTSPKDIILK
CCCCCCCCHHHHHHH
24.3621440633
246AcetylationSPKDIILKLAGITTV
CHHHHHHHHHCCEEE
26.3624489116
254UbiquitinationLAGITTVKGGTGKIV
HHCCEEEECCCEEEE
49.9123749301
2542-HydroxyisobutyrylationLAGITTVKGGTGKIV
HHCCEEEECCCEEEE
49.91-
254SuccinylationLAGITTVKGGTGKIV
HHCCEEEECCCEEEE
49.9123954790
298PhosphorylationSVFPFNKSMIEYLEA
EEECCCHHHHHHHHH
26.5421440633
3102-HydroxyisobutyrylationLEATGRGKIADFAKL
HHHHCCCHHHHHHHH
33.10-
310AcetylationLEATGRGKIADFAKL
HHHHCCCHHHHHHHH
33.1025381059
316AcetylationGKIADFAKLYHKDLL
CHHHHHHHHHHHHHH
49.9624489116
320AcetylationDFAKLYHKDLLSADK
HHHHHHHHHHHCCCC
36.1924489116
351PhosphorylationPYINGPFTPDLATPV
CCCCCCCCCCCCCCH
21.0128889911
381PhosphorylationVRVGLIGSCTNSSYE
EEEEEEECCCCCCHH
15.6919779198
383PhosphorylationVGLIGSCTNSSYEDM
EEEEECCCCCCHHHH
39.5728889911
385PhosphorylationLIGSCTNSSYEDMSR
EEECCCCCCHHHHHH
19.0221440633
386PhosphorylationIGSCTNSSYEDMSRS
EECCCCCCHHHHHHH
34.3119779198
387PhosphorylationGSCTNSSYEDMSRSA
ECCCCCCHHHHHHHH
18.7721440633
391PhosphorylationNSSYEDMSRSASIVK
CCCHHHHHHHHHHHH
35.0920377248
393PhosphorylationSYEDMSRSASIVKDA
CHHHHHHHHHHHHHH
21.0421440633
395PhosphorylationEDMSRSASIVKDAAA
HHHHHHHHHHHHHHH
29.2121440633
398SuccinylationSRSASIVKDAAAHGL
HHHHHHHHHHHHCCC
39.7223954790
3982-HydroxyisobutyrylationSRSASIVKDAAAHGL
HHHHHHHHHHHHCCC
39.72-
398AcetylationSRSASIVKDAAAHGL
HHHHHHHHHHHHCCC
39.7224489116
407PhosphorylationAAAHGLKSKTIFTVT
HHHCCCCCCEEEEEC
39.8221440633
408AcetylationAAHGLKSKTIFTVTP
HHCCCCCCEEEEECC
44.0124489116
4082-HydroxyisobutyrylationAAHGLKSKTIFTVTP
HHCCCCCCEEEEECC
44.01-
409PhosphorylationAHGLKSKTIFTVTPG
HCCCCCCEEEEECCC
28.5428889911
468PhosphorylationDKNTIVSSYNRNFTS
CCCEEEEECCCCCCC
18.6119779198
469PhosphorylationKNTIVSSYNRNFTSR
CCEEEEECCCCCCCC
15.6119779198
5102-HydroxyisobutyrylationRFNPLTDKLKDKDGN
CCCCCCHHCCCCCCC
52.80-
510AcetylationRFNPLTDKLKDKDGN
CCCCCCHHCCCCCCC
52.8024489116
522AcetylationDGNEFMLKPPHGDGL
CCCCCCCCCCCCCCC
44.7224489116
554AcetylationDRSTVEVKVSPTSDR
CCCCEEEEECCCCCC
24.4024489116
556PhosphorylationSTVEVKVSPTSDRLQ
CCEEEEECCCCCCCE
19.4222369663
558PhosphorylationVEVKVSPTSDRLQLL
EEEEECCCCCCCEEC
35.4422369663
559PhosphorylationEVKVSPTSDRLQLLK
EEEECCCCCCCEECC
24.9022369663
566AcetylationSDRLQLLKPFKPWDG
CCCCEECCCCCCCCC
57.9324489116
569AcetylationLQLLKPFKPWDGKDA
CEECCCCCCCCCCCC
54.4424489116
577AcetylationPWDGKDAKDMPILIK
CCCCCCCCCCCEEEE
65.7724489116
584AcetylationKDMPILIKAVGKTTT
CCCCEEEEECCCCCC
33.3124489116
591PhosphorylationKAVGKTTTDHISMAG
EECCCCCCCCCHHCH
30.7121440633
602AcetylationSMAGPWLKYRGHLEN
HHCHHCHHHCCCHHH
29.0924489116
624AcetylationGAINAENKKANCVKN
EEEECCCCCCCCEEE
44.7824489116
630AcetylationNKKANCVKNVYTGEY
CCCCCCEEECCCCCC
42.7824489116
6382-HydroxyisobutyrylationNVYTGEYKGVPDTAR
ECCCCCCCCCCCCHH
49.48-
638SuccinylationNVYTGEYKGVPDTAR
ECCCCCCCCCCCCHH
49.4823954790
638AcetylationNVYTGEYKGVPDTAR
ECCCCCCCCCCCCHH
49.4824489116
697SuccinylationRIHETNLKKQGLLPL
HHHHHCCHHCCCCCC
45.1623954790
707AcetylationGLLPLNFKNPADYDK
CCCCCCCCCHHHHHH
62.0324489116
714AcetylationKNPADYDKINPDDRI
CCHHHHHHCCCCCCE
37.8524489116
767PhosphorylationIEWFKYGSALNKIKA
EEEEEHHHHHHHHCC
26.8821440633
777SuccinylationNKIKADEKK------
HHHCCCCCC------
65.4123954790
777AcetylationNKIKADEKK------
HHHCCCCCC------
65.4125381059

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ACON_YEAST !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ACON_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ACON_YEAST !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MYO4_YEASTMYO4physical
16554755
CALM_YEASTCMD1physical
16554755
HSP42_YEASTHSP42physical
16554755
MLC1_YEASTMLC1physical
16554755
CISY1_YEASTCIT1genetic
18359281
SSB1_YEASTSSB1physical
19536198
ACON2_YEASTACO2genetic
16941010
OPLA_YEASTOXP1genetic
20402795
SRS2_YEASTSRS2genetic
21459050
FUN14_YEASTFUN14genetic
21987634
CALX_YEASTCNE1genetic
21987634
PTH2_YEASTPTH2genetic
21987634
RS8A_YEASTRPS8Agenetic
21987634
RS8B_YEASTRPS8Agenetic
21987634
RKM3_YEASTRKM3genetic
21987634
SEC66_YEASTSEC66genetic
21987634
BEM1_YEASTBEM1genetic
21987634
SWC5_YEASTSWC5genetic
21987634
POP4_YEASTPOP4genetic
21987634
TXTP_YEASTCTP1genetic
21987634
SGF29_YEASTSGF29genetic
21987634
EMC1_YEASTEMC1genetic
21987634
FEN2_YEASTFEN2genetic
21987634
ERP3_YEASTERP3genetic
21987634
BUG1_YEASTBUG1genetic
21987634
YD018_YEASTYDR018Cgenetic
21987634
VMS1_YEASTVMS1genetic
21987634
UBP4_YEASTDOA4genetic
21987634
IPT1_YEASTIPT1genetic
21987634
TPS2_YEASTTPS2genetic
21987634
ADR1_YEASTADR1genetic
21987634
MFB1_YEASTMFB1genetic
21987634
SGPL_YEASTDPL1genetic
21987634
SUM1_YEASTSUM1genetic
21987634
RV167_YEASTRVS167genetic
21987634
SIP1_YEASTSIP1genetic
21987634
SNF1_YEASTSNF1genetic
21987634
UBC8_YEASTUBC8genetic
21987634
VAC8_YEASTVAC8genetic
21987634
ALDH5_YEASTALD5genetic
21987634
SWI4_YEASTSWI4genetic
21987634
PP12_YEASTGLC7genetic
21987634
PUS3_YEASTDEG1genetic
21987634
FMP32_YEASTFMP32genetic
21987634
GET1_YEASTGET1genetic
21987634
PIB2_YEASTPIB2genetic
21987634
SGF73_YEASTSGF73genetic
21987634
MDM34_YEASTMDM34genetic
21987634
MTO1_YEASTMTO1genetic
21987634
GABAT_YEASTUGA1genetic
21987634
NOL10_YEASTENP2genetic
21987634
CBS_YEASTCYS4genetic
21987634
SODM_YEASTSOD2genetic
21987634
BCD1_YEASTBCD1genetic
21987634
OYE2_YEASTOYE2genetic
21987634
APQ12_YEASTAPQ12genetic
21987634
MLP2_YEASTMLP2genetic
21987634
GST1_YEASTGTT1genetic
21987634
LSM1_YEASTLSM1genetic
21987634
PBS2_YEASTPBS2genetic
21987634
YUR1_YEASTYUR1genetic
21987634
RPA34_YEASTRPA34genetic
21987634
INO1_YEASTINO1genetic
21987634
MBR1_YEASTMBR1genetic
21987634
ELF1_YEASTELF1genetic
21987634
DOA1_YEASTDOA1genetic
21987634
UTH1_YEASTUTH1genetic
21987634
FMP46_YEASTFMP46genetic
21987634
PCKA_YEASTPCK1genetic
21987634
VPS13_YEASTVPS13genetic
21987634
IDHC_YEASTIDP2genetic
21987634
UPS1_YEASTUPS1genetic
21987634
CDC42_YEASTCDC42genetic
21987634
ERFB_YEASTERF2genetic
21987634
ARPC3_YEASTARC18genetic
21987634
ELO3_YEASTELO3genetic
21987634
YMD8_YEASTYMD8genetic
21987634
MLH1_YEASTMLH1genetic
21987634
KIME_YEASTERG12genetic
21987634
GPI12_YEASTGPI12genetic
21987634
LKHA4_YEASTLAP2genetic
21987634
RAS2_YEASTRAS2genetic
21987634
OCA1_YEASTOCA1genetic
21987634
IES2_YEASTIES2genetic
21987634
SQS1_YEASTSQS1genetic
21987634
URE2_YEASTURE2genetic
21987634
GOR1_YEASTGOR1genetic
21987634
MCK1_YEASTMCK1genetic
21987634
VPS27_YEASTVPS27genetic
21987634
IF2M_YEASTIFM1genetic
21987634
MDM38_YEASTMDM38genetic
21987634
IRA2_YEASTIRA2genetic
21987634
DCP1_YEASTDCP1genetic
21987634
SLG1_YEASTSLG1genetic
21987634
TIM18_YEASTTIM18genetic
21987634
MRS2_YEASTMRS2genetic
21987634
PDE2_YEASTPDE2genetic
21987634
LPE10_YEASTMFM1genetic
21987634
YDC1_YEASTYDC1genetic
21987634
MGR2_YEASTMGR2genetic
21987634
TYW1_YEASTTYW1genetic
21987634
GAL4_YEASTGAL4genetic
21987634
FUMH_YEASTFUM1genetic
21987634
SAM3_YEASTSAM3genetic
21987634
YME1_YEASTYME1genetic
21987634
YOP1_YEASTYOP1genetic
21987634
VPS4_YEASTVPS4genetic
21987634
ACON_YEASTACO1physical
22940862
ACON2_YEASTACO2genetic
23106124
RTG1_YEASTRTG1genetic
24066190
RTG2_YEASTRTG2genetic
24066190
RTG3_YEASTRTG3genetic
24066190
CISY1_YEASTCIT1genetic
24066190
MRS3_YEASTMRS3genetic
24066190
MRS4_YEASTMRS4genetic
24066190
SODC_YEASTSOD1genetic
24066190
ICP55_YEASTICP55physical
19837041
ACEA_YEASTICL1genetic
25828707
SKN1_YEASTSKN1genetic
27708008
ECM25_YEASTECM25genetic
27708008
VMS1_YEASTVMS1genetic
27708008
KNS1_YEASTKNS1genetic
27708008
FMP25_YEASTFMP25genetic
27708008
DIA1_YEASTDIA1genetic
27708008
TPM1_YEASTTPM1genetic
27708008
IRA2_YEASTIRA2genetic
27708008
2A5D_YEASTRTS1genetic
27708008
ULS1_YEASTULS1genetic
27708008
PMP1_YEASTPMP1physical
26404137

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ACON_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-556, AND MASSSPECTROMETRY.
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-351, AND MASSSPECTROMETRY.
"Profiling phosphoproteins of yeast mitochondria reveals a role ofphosphorylation in assembly of the ATP synthase.";
Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B.,van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.;
Mol. Cell. Proteomics 6:1896-1906(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-409, AND MASSSPECTROMETRY.

TOP