MYO4_YEAST - dbPTM
MYO4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MYO4_YEAST
UniProt AC P32492
Protein Name Myosin-4
Gene Name MYO4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1471
Subcellular Localization Bud . Accumulates preferentially in growing buds.
Protein Description Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Recruited to specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease, via its interaction with SHE3..
Protein Sequence MSFEVGTKCWYPHKEQGWIGGEVTKNDFFEGTFHLELKLEDGETVSIETNSFENDDDHPTLPVLRNPPILESTDDLTTLSYLNEPAVLHAIKKRYMNGQIYTYSGIVLIAANPFDKVDHLYSREMIQNYSSKRKDELEPHLFAIAEEAYRFMVHEKANQTVVVSGESGAGKTVSAKYIMRYFASVQESNNREGEVEMSQIESQILATNPIMEAFGNAKTTRNDNSSRFGKYLQILFDENTTIRGSKIRTYLLEKSRLVYQPETERNYHIFYQILEGLPEPVKQELHLSSPKDYHYTNQGGQPNIAGIDEAREYKITTDALSLVGINHETQLGIFKILAGLLHIGNIEMKMTRNDASLSSEEQNLQIACELLGIDPFNFAKWIVKKQIVTRSEKIVTNLNYNQALIARDSVAKFIYSTLFDWLVDNINKTLYDPELDQQDHVFSFIGILDIYGFEHFEKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYVKEEIEWSFIEFSDNQPCIDLIENKLGILSLLDEESRLPSGSDESWASKLYSAFNKPPSNEVFSKPRFGQTKFIVSHYAVDVEYEVEGFIEKNRDSVSLGHLDVFKATTNPIFKQILDNRELRSDDAPEEQNTEKKIMIPARLSQKKPTLGSMFKKSLGELMAIINSTNVHYIRCIKPNSEKKPWEFDNLMVLSQLRACGVLETIRISCAGFPSRWTFDEFVQRYFLLTDYSLWSGILYNPDLPKEAIVNFCQSILDATISDSAKYQIGNTKIFFKAGMLAFLEKLRTNKMNEICIIIQKKIRARYYRLQYLQTMESIKKCQSQIRSLLVRTRVDHELKTRAAILLQTNIRALWKREYYRAAIGQIIKLQCTCKRKLILDSVNRKFMLMAAVIIQSYIRSYGHKTDYRTLKRSSILVQSAMRMQLARRRYIVLQKEVEERNIRASYGIGLLEEAIEFKNSFILNLEMLNDSYTRLTQLLQGDLSNIPSKQRQEYETIVNGYNDKISKLKTLQVEIMNTLNKKNALKERKKKQSSLIQSHMQSLAAIKGNKPSRLSDEVKSMKQELAFIENVIAQDFTTTYSANKNDKVKGLGIAGQQVKPKLVNVIRRESGNPDLLELLMDLNCYTLEVTEGYLKKVNVTEVNGDNVLGPIHVITTVVSSLVRNGLLIQSSKFISKVLLTVESIVMSLPKDETMLGGIFWLSNLSRLPAFAANQKTLYEANGGDEKDKLTLIYLNDLENETLKVFDKIYSTWLVKFMKHASAHIEIFDMVLNEKLFKNSGDEKFAKLFTFLNEFDAVLCKFQVVDSMHTKIFNDTLKYLNVMLFNDLITKCPALNWKYGYEVDRNIERLVSWFEPRIEDVRPNLIQIIQAVKILQLKISNLNEFKLLFDFWYALNPAQIQAILLKYKPANKGEAGVPNEILNYLANVIKRENLSLPGKMEIMLSAQFDSAKNHLRYDTSAITQNSNTEGLATVSKIIKLDRK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
95PhosphorylationLHAIKKRYMNGQIYT
HHHHHHHHHCCCEEE		12.1030377154
101PhosphorylationRYMNGQIYTYSGIVL
HHHCCCEEEEEEEEE		7.5530377154
102PhosphorylationYMNGQIYTYSGIVLI
HHCCCEEEEEEEEEE		16.9130377154
103PhosphorylationMNGQIYTYSGIVLIA
HCCCEEEEEEEEEEE		6.4730377154
104PhosphorylationNGQIYTYSGIVLIAA
CCCEEEEEEEEEEEC		17.7830377154
167PhosphorylationTVVVSGESGAGKTVS
EEEEECCCCCCCCCC		37.1527017623
218UbiquitinationMEAFGNAKTTRNDNS
HHHHCCCCCCCCCCC		55.2024961812
231PhosphorylationNSSRFGKYLQILFDE
CCCHHHHEEHEEECC		12.2927017623
245PhosphorylationENTTIRGSKIRTYLL
CCCCCCCCHHHEEHH		18.3027017623
514UbiquitinationCIDLIENKLGILSLL
HHHHHHHHHCHHHHC		34.9922106047
581UbiquitinationEVEGFIEKNRDSVSL
EEEEHHHCCCCCCEE		53.0917644757
585PhosphorylationFIEKNRDSVSLGHLD
HHHCCCCCCEECCHH		15.4624961812
587PhosphorylationEKNRDSVSLGHLDVF
HCCCCCCEECCHHHH		32.3624961812
595UbiquitinationLGHLDVFKATTNPIF
ECCHHHHHHHCCHHH		44.6717644757
874UbiquitinationILDSVNRKFMLMAAV
HHHHHCHHHHHHHHH		29.8917644757
965PhosphorylationNDSYTRLTQLLQGDL
CCHHHHHHHHHHCCC		17.5528889911
1041PhosphorylationAIKGNKPSRLSDEVK
HHHCCCCCCCHHHHH		47.6828889911
1044PhosphorylationGNKPSRLSDEVKSMK
CCCCCCCHHHHHHHH		30.5223749301
1090AcetylationAGQQVKPKLVNVIRR
CCCCCCHHHHHHHHH		60.3924489116
1238PhosphorylationLKVFDKIYSTWLVKF
HHHHHHHHHHHHHHH		13.0425533186
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MYO4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MYO4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MYO4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ACT_YEASTACT1physical
11805826
ADH1_YEASTADH1physical
11805826
GCN1_YEASTGCN1physical
11805826
HSC82_YEASTHSC82physical
11805826
IMB4_YEASTKAP123physical
11805826
MLC1_YEASTMLC1physical
11805826
EIF3C_YEASTNIP1physical
11805826
SHE2_YEASTSHE2physical
11805826
SHE3_YEASTSHE3physical
11805826
ARX1_YEASTARX1physical
11805826
EF3A_YEASTYEF3physical
11805826
SHE4_YEASTSHE4physical
12725728
SHE3_YEASTSHE3physical
11032818
ASH1_YEASTASH1physical
10792032
SHE2_YEASTSHE2physical
15328357
SHE3_YEASTSHE3physical
15328357
ASH1_YEASTASH1genetic
15082763
HEK2_YEASTHEK2genetic
15082763
HEK2_YEASTHEK2genetic
11867544
ACT_YEASTACT1physical
16429126
MLC1_YEASTMLC1physical
16429126
SHE2_YEASTSHE2physical
16429126
SHE3_YEASTSHE3physical
16429126
IMDH4_YEASTIMD4physical
16429126
SHE3_YEASTSHE3physical
17893244
ACT_YEASTACT1physical
17893244
SHE2_YEASTSHE2physical
18467557
SHE3_YEASTSHE3physical
18467557
MYO4_YEASTMYO4physical
18467557
PML1_YEASTPML1genetic
19061648
POM34_YEASTPOM34genetic
19061648
NUP53_YEASTNUP53genetic
19061648
BRR1_YEASTBRR1genetic
19061648
SHE2_YEASTSHE2physical
19429778
SHE3_YEASTSHE3physical
19429778
SHE3_YEASTSHE3physical
18175803
ACT_YEASTACT1physical
18175803
SHE3_YEASTSHE3physical
20457760
SHE2_YEASTSHE2physical
20457760
MYO4_YEASTMYO4physical
20457760
CORO_YEASTCRN1physical
20813846
SHE4_YEASTSHE4physical
21115842
MLC1_YEASTMLC1genetic
23275495
RLA4_YEASTRPP2Bgenetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
LIPB_YEASTLIP2genetic
27708008
COX7_YEASTCOX7genetic
27708008
SAP30_YEASTSAP30genetic
27708008
AEP2_YEASTAEP2genetic
27708008
HDA1_YEASTHDA1genetic
27708008
MDM12_YEASTMDM12genetic
27708008
VPS4_YEASTVPS4genetic
27708008
RL19A_YEASTRPL19Bgenetic
27708008
RL19B_YEASTRPL19Bgenetic
27708008
SHE1_YEASTSHE1genetic
27708008
SIF2_YEASTSIF2genetic
27708008
SWC5_YEASTSWC5genetic
27708008
ATG22_YEASTATG22genetic
27708008
MGR1_YEASTMGR1genetic
27708008
BUD31_YEASTBUD31genetic
27708008
SED4_YEASTSED4genetic
27708008
IMG2_YEASTIMG2genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
MTU1_YEASTSLM3genetic
27708008
PEX19_YEASTPEX19genetic
27708008
GCST_YEASTGCV1genetic
27708008
RM01_YEASTMRPL1genetic
27708008
INO2_YEASTINO2genetic
27708008
PEX5_YEASTPEX5genetic
27708008
PEX3_YEASTPEX3genetic
27708008
SWR1_YEASTSWR1genetic
27708008
SHE9_YEASTSHE9genetic
27708008
YFH6_YEASTYFR006Wgenetic
27708008
HOS2_YEASTHOS2genetic
27708008
CHO2_YEASTCHO2genetic
27708008
PHB2_YEASTPHB2genetic
27708008
RS27B_YEASTRPS27Bgenetic
27708008
GIC1_YEASTGIC1genetic
27708008
YIQ3_YEASTYIL163Cgenetic
27708008
DAL81_YEASTDAL81genetic
27708008
RS21B_YEASTRPS21Bgenetic
27708008
MPCP_YEASTMIR1genetic
27708008
MET5_YEASTMET5genetic
27708008
MDM35_YEASTMDM35genetic
27708008
RM49_YEASTMRP49genetic
27708008
CBT1_YEASTCBT1genetic
27708008
SHB17_YEASTSHB17genetic
27708008
COX12_YEASTCOX12genetic
27708008
RIC1_YEASTRIC1genetic
27708008
ERG3_YEASTERG3genetic
27708008
ENV10_YEASTENV10genetic
27708008
PEX13_YEASTPEX13genetic
27708008
COQ11_YEASTYLR290Cgenetic
27708008
VID22_YEASTVID22genetic
27708008
YL415_YEASTYLR415Cgenetic
27708008
CTF18_YEASTCTF18genetic
27708008
HOR7_YEASTHOR7genetic
27708008
SIW14_YEASTSIW14genetic
27708008
COX5A_YEASTCOX5Agenetic
27708008
RNH2A_YEASTRNH201genetic
27708008
EOS1_YEASTEOS1genetic
27708008
SWS2_YEASTSWS2genetic
27708008
RCF2_YEASTRCF2genetic
27708008
BUB3_YEASTBUB3genetic
27708008
CY1_YEASTCYT1genetic
27708008
AZF1_YEASTAZF1genetic
27708008
UBP2_YEASTUBP2genetic
27708008
MNE1_YEASTMNE1genetic
27708008
RAD17_YEASTRAD17genetic
27708008
BEM4_YEASTBEM4genetic
27708008
COX10_YEASTCOX10genetic
27708008
KAPB_YEASTTPK2genetic
27708008
RU2A_YEASTLEA1genetic
27708008
KAR3_YEASTKAR3genetic
27708008
SHE3_YEASTSHE3physical
25826656
SHE2_YEASTSHE2physical
25826656
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MYO4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-965, AND MASSSPECTROMETRY.

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