SED4_YEAST - dbPTM
SED4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SED4_YEAST
UniProt AC P25365
Protein Name Putative guanine nucleotide-exchange factor SED4
Gene Name SED4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1065
Subcellular Localization Endoplasmic reticulum membrane
Single-pass type II membrane protein. Golgi apparatus membrane
Single-pass type II membrane protein . In the process of transport, SED4 itself may migrate to the Golgi apparatus and function in subsequent transport e
Protein Description Putative guanine nucleotide-exchange factor (GEF) involved in the formation or budding of transport vesicles from the ER. Positive regulator of SAR1 probably through inhibition of the GTPase activation by SEC23..
Protein Sequence MSGNSANYDVGYPIYGAKFINEGTLLVAGGGGQFNSSFPNKITALKVNFQKKKHIRRFREITLDSIDDAPTSLDCNNNLILVGCNELFNDSSMENVNHHLRKFVFEQEHLKFVASIDFNRTTDPSVFTKFVYINQRATVAAIASSEVPTVIRIIDPRNLTENYEIETGREVNDLHFAPNGILLSYITSNSLEVASVRDGNFVARKTDFDKNLVLSNIRFLNDNTLLVAASLSNSDGVSLLKLGVSSKGVKILKTASFMFDLNGITSMDVSPNKKFVALSSNDNLVAIVSVEKLKLVQLVPRVHESTITKVTFSPDSRYLASTSMGNTINVLKLSGTSSSILRNIWKFFLNFVLLVVLAGAIQLGYKHNVHGFIYKHAHDIYKSKFKENTTIDQGSSSYFTINDDYRGITESADIISATDVASDIETEFSSFDTSTMRTTTEDEQKFVWISSSADSQFTSADIPTSASSSSSSSSSSFYEESVTNEPIVSSPTSEITKPLASPTEPNIVEKPSLPLNSESIDLLSSSSNSITEYPEPTPDLEEKLSSLIVEQSESEITTDRESVSKLLSTESPSLSHMPSSSSSSLSLSSSLTTSPTTALSTSTATAVTTTQTNPTNDAANTSFLDNSKPASTREIYKTKIITEVITKIEYRNIPASDSNAEAEQYVTTSSSMLLTPTDTMVSSPVSEIDPIASELERMVETPTHSISIASEFDSVASNLIPNEEILSTSASQDSISSHPSTFSDSSITSGFQSIEVSTVTSSVLASESIPSISDSTFSKFHSISEPVSSAIVETATSSFSKTETKTSRVIAFSTEDSERSSALIDNSEYTSVLADNLEPTSVLADNSEPTSVLADSSEPTSVFTDAVQSPKTSVGQSSLSESTNIEGTSMASMIFSSSGASIGALSDIGKGTLSVESASSTVAQPMPGVTTTAPSFVSSPHKISASSIDASGFVQKEIMIEVQSSKDSSEAFGVRHKISENVNTPVSRMLTTEMQASGTVDVTEDVSLSSEVISALNVEITSLPNPVAPPQTIAAPLNNNSNTNIVNDDNAVAGTVNYAGLHDEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
24PhosphorylationAKFINEGTLLVAGGG
EEEECCCCEEEECCC		15.6724930733
36PhosphorylationGGGGQFNSSFPNKIT
CCCCCCCCCCCCCEE		34.3424930733
37PhosphorylationGGGQFNSSFPNKITA
CCCCCCCCCCCCEEE		45.9124930733
65PhosphorylationFREITLDSIDDAPTS
HHEEEECCCCCCCCC		30.9127214570
210UbiquitinationARKTDFDKNLVLSNI
EEECCCCCCCEEEEE		52.7724961812
294AcetylationIVSVEKLKLVQLVPR
EEEEEEEEEEEEECC		58.6524489116
318PhosphorylationTFSPDSRYLASTSMG
EECCCCCEEEECCCC		15.5728889911
321PhosphorylationPDSRYLASTSMGNTI
CCCCEEEECCCCCCE		20.5828889911
322PhosphorylationDSRYLASTSMGNTIN
CCCEEEECCCCCCEE		19.6828889911
327PhosphorylationASTSMGNTINVLKLS
EECCCCCCEEEEECC		14.2728889911
336PhosphorylationNVLKLSGTSSSILRN
EEEECCCCCHHHHHH		23.2728889911
339PhosphorylationKLSGTSSSILRNIWK
ECCCCCHHHHHHHHH		25.9628889911
388N-linked_GlycosylationYKSKFKENTTIDQGS
HHHHCCCCCCCCCCC		43.01-
395PhosphorylationNTTIDQGSSSYFTIN
CCCCCCCCCCEEEEC		15.5219779198
405PhosphorylationYFTINDDYRGITESA
EEEECCCCCCCCCCC		17.3819779198
620N-linked_GlycosylationNPTNDAANTSFLDNS
CCCCCCCCCCCCCCC		37.67-
872PhosphorylationDAVQSPKTSVGQSSL
CCCCCCCCCCCCCCC		31.8427017623
873PhosphorylationAVQSPKTSVGQSSLS
CCCCCCCCCCCCCCC		30.3127017623
877PhosphorylationPKTSVGQSSLSESTN
CCCCCCCCCCCCCCC		27.5827017623
878PhosphorylationKTSVGQSSLSESTNI
CCCCCCCCCCCCCCC		28.2027017623
880PhosphorylationSVGQSSLSESTNIEG
CCCCCCCCCCCCCCC		31.3027017623
883PhosphorylationQSSLSESTNIEGTSM
CCCCCCCCCCCCCCH		35.8427017623
889PhosphorylationSTNIEGTSMASMIFS
CCCCCCCCHHHHHHC		24.1727017623
897PhosphorylationMASMIFSSSGASIGA
HHHHHHCCCCCEEEC		23.2627017623
898PhosphorylationASMIFSSSGASIGAL
HHHHHCCCCCEEECC		36.8627017623
901PhosphorylationIFSSSGASIGALSDI
HHCCCCCEEECCCCC		25.6927017623
906PhosphorylationGASIGALSDIGKGTL
CCEEECCCCCCCCEE		27.0127017623
912PhosphorylationLSDIGKGTLSVESAS
CCCCCCCEEEEEECC		21.2427017623
938PhosphorylationTTAPSFVSSPHKISA
CCCCCCCCCCCCCCH		35.8227017623
946PhosphorylationSPHKISASSIDASGF
CCCCCCHHHCCCCCC		22.4927017623
1039N-linked_GlycosylationTIAAPLNNNSNTNIV
EEEEECCCCCCCCCC		62.07-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SED4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SED4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SED4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SEC16_YEASTSEC16physical
7593162
OST5_YEASTOST5genetic
16269340
RGP1_YEASTRGP1genetic
16269340
YPR71_YEASTYPR071Wgenetic
16269340
GUP1_YEASTGUP1genetic
16269340
OS9_YEASTYOS9genetic
16269340
ICE2_YEASTICE2genetic
16269340
SEC12_YEASTSEC12genetic
7593162
SEC13_YEASTSEC13genetic
7593162
SEC16_YEASTSEC16genetic
7593162
SEC23_YEASTSEC23genetic
7593162
SAR1_YEASTSAR1genetic
7593162
ERD1_YEASTERD1genetic
19325107
ERP1_YEASTERP1genetic
19325107
TMEDA_YEASTERV25genetic
19325107
GET1_YEASTGET1genetic
19325107
GET2_YEASTGET2genetic
19325107
PER1_YEASTPER1genetic
19325107
TED1_YEASTTED1genetic
19325107
YHN8_YEASTYHR078Wgenetic
19325107
GCS1_YEASTGCS1genetic
19325107
SEY1_YEASTSEY1genetic
19325107
SAR1_YEASTSAR1physical
21291503
MOB2_YEASTMOB2genetic
27708008
PMP3_YEASTPMP3genetic
27708008
YG1X_YEASTYGR050Cgenetic
27708008
POM33_YEASTPOM33genetic
27708008
PMS1_YEASTPMS1genetic
27708008
ATP23_YEASTATP23genetic
27708008
ENB1_YEASTENB1genetic
27708008
YVC1_YEASTYVC1genetic
27708008
CDC24_YEASTCDC24genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
GPI11_YEASTGPI11genetic
27708008
YJ9I_YEASTYJR141Wgenetic
27708008
NTR2_YEASTNTR2genetic
27708008
BET3_YEASTBET3genetic
27708008
CFT2_YEASTCFT2genetic
27708008
SEC13_YEASTSEC13genetic
27708008
CD123_YEASTCDC123genetic
27708008
LST8_YEASTLST8genetic
27708008
RIB2_YEASTRIB2genetic
27708008
ESA1_YEASTESA1genetic
27708008
SEC16_YEASTSEC16genetic
27708008
BUR1_YEASTSGV1genetic
27708008
PGTB2_YEASTBET2genetic
27708008
ECM15_YEASTECM15genetic
27708008
SCS22_YEASTSCS22genetic
27708008
GAL10_YEASTGAL10genetic
27708008
YD132_YEASTYDR132Cgenetic
27708008
CWC21_YEASTCWC21genetic
27708008
YD514_YEASTYDR514Cgenetic
27708008
AIM11_YEASTAIM11genetic
27708008
MIC19_YEASTMIC19genetic
27708008
PHO4_YEASTPHO4genetic
27708008
YGZ2_YEASTYGL242Cgenetic
27708008
ADH4_YEASTADH4genetic
27708008
OPI1_YEASTOPI1genetic
27708008
AIM17_YEASTAIM17genetic
27708008
SDHX_YEASTYJL045Wgenetic
27708008
DHOM_YEASTHOM6genetic
27708008
TCD2_YEASTTCD2genetic
27708008
FEN1_YEASTRAD27genetic
27708008
ELF1_YEASTELF1genetic
27708008
CSF1_YEASTCSF1genetic
27708008
YL278_YEASTYLR278Cgenetic
27708008
TDA5_YEASTTDA5genetic
27708008
SCJ1_YEASTSCJ1genetic
27708008
ARE2_YEASTARE2genetic
27708008
SIN3_YEASTSIN3genetic
27708008
HAT1_YEASTHAT1genetic
27708008
CHL1_YEASTCHL1genetic
27708008
PMA2_YEASTPMA2genetic
27708008
EF1G1_YEASTCAM1genetic
27708008
COX10_YEASTCOX10genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SED4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65, AND MASSSPECTROMETRY.

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