ENB1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ENB1_YEAST
• UniProt AC: Q08299
• Protein Name: Siderophore iron transporter ENB1
• Gene Name: ENB1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 606
• Subcellular Localization: Endosome membrane; Multi-pass membrane protein.
• Protein Description: Involved in the transport of siderophore enterobactin and so has a role in iron homeostasis..
• Protein Sequence: MLETDHSRNDNLDDKSTVCYSEKTDSNVEKSTTSGLRRIDAVNKVLSDYSSFTAFGVTFSSLKTALLVALFLQGYCTGLGGQISQSIQTYAANSFGKHSQVGSINTVKSIVASVVAVPYARISDRFGRIECWIFALVLYTIGEIISAATPTFSGLFAGIVIQQFGYSGFRLLATALTGDLSGLRDRTFAMNIFLIPVIINTWVSGNIVSSVAGNVAPYKWRWGYGIFCIIVPISTLILVLPYVYAQYISWRSGKLPPLKLKEKGQTLRQTLWKFADDINLIGVILFTAFLVLVLLPLTIAGGATSKWREGHIIAMIVVGGCLGFIFLIWELKFAKNPFIPRVYLGDPTIYVALLMEFVWRLGLQIELEYLVTVLMVAFGESTLSAQRIAQLYNFLQSCTNIVVGIMLHFYPHPKVFVVAGSLLGVIGMGLLYKYRVVYDGISGLIGAEIVVGIAGGMIRFPMWTLVHASTTHNEMATVTGLLMSVYQIGDAVGASIAGAIWTQRLAKELIQRLGSSLGMAIYKSPLNYLKKYPIGSEVRVQMIESYSKIQRLLIIVSISFAAFNAVLCFFLRGFTVNKKQSLSAEEREKEKLKIKQQSWLRRVIGY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MLETDHSRNDN ----CCCCCCCCCCC	34.74	21440633
7	Phosphorylation	-MLETDHSRNDNLDD -CCCCCCCCCCCCCC	35.27	20377248
15	Ubiquitination	RNDNLDDKSTVCYSE CCCCCCCCCCEEEEC	47.93	23749301
16	Phosphorylation	NDNLDDKSTVCYSEK CCCCCCCCCEEEECC	32.82	21440633
17	Phosphorylation	DNLDDKSTVCYSEKT CCCCCCCCEEEECCC	21.97	25704821
20	Phosphorylation	DDKSTVCYSEKTDSN CCCCCEEEECCCCCC	18.61	21440633
21	Phosphorylation	DKSTVCYSEKTDSNV CCCCEEEECCCCCCC	27.73	28889911
24	Phosphorylation	TVCYSEKTDSNVEKS CEEEECCCCCCCCHH	40.38	19779198
34	Phosphorylation	NVEKSTTSGLRRIDA CCCHHCCHHHHHHHH	35.60	27017623
532	Phosphorylation	PLNYLKKYPIGSEVR CCHHHHHCCCCCEEH	9.86	19779198
545	Phosphorylation	VRVQMIESYSKIQRL EHHHHHHCCHHHHHH	24.63	19779198
583	Phosphorylation	VNKKQSLSAEEREKE CCHHHCCCHHHHHHH	38.59	17287358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ENB1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ENB1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ENB1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PDE1_YEAST	PDE1	genetic	20093466
NMD2_YEAST	NMD2	genetic	20093466
SIT1_YEAST	SIT1	genetic	20526336
MRM2_YEAST	MRM2	genetic	27708008
MED5_YEAST	NUT1	genetic	27708008
PDE1_YEAST	PDE1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7 AND SER-583, AND MASSSPECTROMETRY.
PubMed: 17287358