PDE1_YEAST - dbPTM
PDE1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PDE1_YEAST
UniProt AC P22434
Protein Name 3',5'-cyclic-nucleotide phosphodiesterase 1
Gene Name PDE1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 369
Subcellular Localization
Protein Description Controls the level of cAMP in yeast cells, together with the high-affinity cAMP phosphodiesterase (PDE2)..
Protein Sequence MVVFEITILGANGGPTEYGTQCFILKPARTEDPELIAVDGGAGMYQLREMLVQGRNENEGDDELVPSFYEHDREPIEFFIDSKLNIQKGLSKSLLQSLKRQGEHFESANTMKKTYEVFQGITDYYITHPHLDHISGLVVNSPSIYEQENSKKKTIWGLPHTIDVLQKHVFNDLIWPDLTAERSRKLKLKCLNPKEVQKCTIFPWDVIPFKVHHGIGVKTGAPVYSTFYIFRDRKSKDCIIVCGDVEQDRRESEESLLEEFWSYVAENIPLVHLKGILVECSCPLSSKPEQLYGHLSPIYLINELSNLNTLYNSSKGLSGLNVIVTHVKSTPAKRDPRLTILEELRFLAEERNLGDLRISIALEGHTLFL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
167UbiquitinationHTIDVLQKHVFNDLI
CHHHHHHHHCCCCCC		37.2617644757
252PhosphorylationVEQDRRESEESLLEE
HHHHHHHCHHHHHHH		44.8728889911
311PhosphorylationLSNLNTLYNSSKGLS
HCCHHHHCCCCCCCC		15.8028889911
313PhosphorylationNLNTLYNSSKGLSGL
CHHHHCCCCCCCCCC		21.6228889911
314PhosphorylationLNTLYNSSKGLSGLN
HHHHCCCCCCCCCCE		27.4028889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PDE1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PDE1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PDE1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PDE2_YEASTPDE2genetic
9880329
PDE2_YEASTPDE2genetic
1849280
PDE2_YEASTPDE2genetic
15629464
PDE2_YEASTPDE2genetic
10975254
MSI1_YEASTMSI1genetic
10975254
EPT1_YEASTEPT1genetic
21623372
PYRE_YEASTURA5genetic
21623372
CHO2_YEASTCHO2genetic
21623372
POS5_YEASTPOS5genetic
21623372
SOL3_YEASTSOL3genetic
21623372
ALDH6_YEASTALD6genetic
21623372
TPS1_YEASTTPS1genetic
21623372
GSH1_YEASTGSH1genetic
21623372
TREB_YEASTNTH2genetic
21623372
ARO1_YEASTARO1genetic
21623372
PHSG_YEASTGPH1genetic
21623372
METK2_YEASTSAM2genetic
21623372
PDE2_YEASTPDE2genetic
21749328
PP2C1_YEASTPTC1genetic
27708008
SWD1_YEASTSWD1genetic
27708008
PUR7_YEASTADE1genetic
27708008
HAP3_YEASTHAP3genetic
27708008
SKT5_YEASTSKT5genetic
27708008
ATM_YEASTTEL1genetic
27708008
NAA38_YEASTMAK31genetic
27708008
NHP10_YEASTNHP10genetic
27708008
ASF2_YEASTASF2genetic
27708008
HIBCH_YEASTEHD3genetic
27708008
AMDY_YEASTAMD2genetic
27708008
POLH_YEASTRAD30genetic
27708008
PKH1_YEASTPKH1genetic
27708008
IES5_YEASTIES5genetic
27708008
RAD4_YEASTRAD4genetic
27708008
IES1_YEASTIES1genetic
27708008
FAR7_YEASTFAR7genetic
27708008
ERP6_YEASTERP6genetic
27708008
ATE1_YEASTATE1genetic
27708008
RME1_YEASTRME1genetic
27708008
HSV2_YEASTHSV2genetic
27708008
NEM1_YEASTNEM1genetic
27708008
ELO1_YEASTELO1genetic
27708008
YJ09_YEASTYJR039Wgenetic
27708008
YJ24_YEASTKCH1genetic
27708008
KAPC_YEASTTPK3genetic
27708008
UIP5_YEASTUIP5genetic
27708008
ENV10_YEASTENV10genetic
27708008
FAR8_YEASTFAR8genetic
27708008
RIM11_YEASTRIM11genetic
27708008
YNE6_YEASTYNL046Wgenetic
27708008
FAR11_YEASTFAR11genetic
27708008
ALG6_YEASTALG6genetic
27708008
CY1_YEASTCYT1genetic
27708008
RUP1_YEASTRUP1genetic
27708008
YRR1_YEASTYRR1genetic
27708008
HES1_YEASTHES1genetic
27708008
PDE2_YEASTPDE2genetic
27708008
YP034_YEASTYPL034Wgenetic
27708008
TBP6_YEASTYTA6genetic
27708008
SYH1_YEASTSYH1genetic
27708008
ISU1_YEASTISU1genetic
27708008
TGS1_YEASTTGS1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PDE1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-311; SER-313 ANDSER-314, AND MASS SPECTROMETRY.

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