ASF2_YEAST - dbPTM
ASF2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ASF2_YEAST
UniProt AC P32448
Protein Name Anti-silencing protein 2
Gene Name ASF2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 525
Subcellular Localization
Protein Description Derepression of silent mating type loci when overexpressed..
Protein Sequence MPKNRGVLDAITRSVIDGSDQESSSSFNSDKEYAAVTKGLSSSRVQKKSSLRQMKSKVKELQSLVNHYRENEAALVSSAKLLSGEIIGYEIKMASLHGKMKSILDENNALKETHKSSAEKRIELVRLPSSKEERNYDEYTLLVNLKKEICAKLQDYKNVQNTVNTKLDEIHTFHEKYYEGLELSLDSKVFDAESSKELAKVRRELNNVRKNSEIKVNNLKMQLLQATKSLEHLKKQAKAKDDYLKCIPELVDKANLTMLSYKKSIANQRETIEALQAELSQQSETKGQIETETQNQVQIPTNVTLVDPFEENNPEDLFAIQEQELQDLRLHKKMADERSRTTHLHLERKNNTIKLLQSYVQSLIQRLPPAQRKHHLGIFQKLGSEKSCPLAPAVASTYAPLLLLSQHSNHQEIDNTPQRLLLAAPDGQSYSEKSTTLNLDYSSRKSYLSRLQPPHIANLKSLTLKTLPRVPTDSPQLPSKDKSQETAKKDDRPKLVANEPVTLDTSTPPVAQSLADSKHCSGLHK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
19PhosphorylationTRSVIDGSDQESSSS
HHHHHCCCCCCCCCC		32.1628889911
77PhosphorylationENEAALVSSAKLLSG
HCHHHHHHHHHHHHC		25.9819779198
78PhosphorylationNEAALVSSAKLLSGE
CHHHHHHHHHHHHCC		23.1919779198
83PhosphorylationVSSAKLLSGEIIGYE
HHHHHHHHCCCCCCE		44.8319779198
89PhosphorylationLSGEIIGYEIKMASL
HHCCCCCCEEEHHHH		12.2228889911
95PhosphorylationGYEIKMASLHGKMKS
CCEEEHHHHCHHHHH		19.8728889911
129PhosphorylationIELVRLPSSKEERNY
EEEEECCCCHHHCCC		59.6428889911
162PhosphorylationDYKNVQNTVNTKLDE
HHCCHHHHHHHCHHH		9.6828889911
165PhosphorylationNVQNTVNTKLDEIHT
CHHHHHHHCHHHHHH		28.7528889911
358PhosphorylationNTIKLLQSYVQSLIQ
HHHHHHHHHHHHHHH		27.5227017623
362PhosphorylationLLQSYVQSLIQRLPP
HHHHHHHHHHHHCCH		19.8627017623
431PhosphorylationAPDGQSYSEKSTTLN
CCCCCCCCCCCCEEC		43.7430377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ASF2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ASF2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ASF2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SUT1_YEASTSUT1physical
18467557
ATG8_YEASTATG8genetic
27708008
IMG2_YEASTIMG2genetic
27708008
SAC3_YEASTSAC3genetic
27708008
PEX5_YEASTPEX5genetic
27708008
BCS1_YEASTBCS1genetic
27708008
RV167_YEASTRVS167genetic
27708008
MED5_YEASTNUT1genetic
27708008
ATG1_YEASTATG1genetic
27708008
UBCX_YEASTPEX4genetic
27708008
PHB2_YEASTPHB2genetic
27708008
SNF6_YEASTSNF6genetic
27708008
MED20_YEASTSRB2genetic
27708008
VPS55_YEASTVPS55genetic
27708008
MRT4_YEASTMRT4genetic
27708008
CTK1_YEASTCTK1genetic
27708008
FPS1_YEASTFPS1genetic
27708008
UPS1_YEASTUPS1genetic
27708008
YPT7_YEASTYPT7genetic
27708008
UBX2_YEASTUBX2genetic
27708008
MGR3_YEASTMGR3genetic
27708008
SIN3_YEASTSIN3genetic
27708008
SFL1_YEASTSFL1genetic
27708008
RS10A_YEASTRPS10Agenetic
27708008
BECN1_YEASTVPS30genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
YME1_YEASTYME1genetic
27708008
BRR1_YEASTBRR1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ASF2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129, AND MASSSPECTROMETRY.

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