PEX5_YEAST - dbPTM
PEX5_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PEX5_YEAST
UniProt AC P35056
Protein Name Peroxisomal targeting signal receptor
Gene Name PEX5
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 612
Subcellular Localization Cytoplasm. Peroxisome membrane
Peripheral membrane protein. Its distribution appears to be dynamic. It is probably a cycling receptor found mainly in the cytoplasm and as well associated to the peroxisomal membrane through a docking factor (PEX13).
Protein Description Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import..
Protein Sequence MDVGSCSVGNNPLAQLHKHTQQNKSLQFNQKNNGRLNESPLQGTNKPGISEAFISNVNAISQENMANMQRFINGEPLIDDKRRMEIGPSSGRLPPFSNVHSLQTSANPTQIKGVNDISHWSQEFQGSNSIQNRNADTGNSEKAWQRGSTTASSRFQYPNTMMNNYAYASMNSLSGSRLQSPAFMNQQQSGRSKEGVNEQEQQPWTDQFEKLEKEVSENLDINDEIEKEENVSEVEQNKPETVEKEEGVYGDQYQSDFQEVWDSIHKDAEEVLPSELVNDDLNLGEDYLKYLGGRVNGNIEYAFQSNNEYFNNPNAYKIGCLLMENGAKLSEAALAFEAAVKEKPDHVDAWLRLGLVQTQNEKELNGISALEECLKLDPKNLEAMKTLAISYINEGYDMSAFTMLDKWAETKYPEIWSRIKQQDDKFQKEKGFTHIDMNAHITKQFLQLANNLSTIDPEIQLCLGLLFYTKDDFDKTIDCFESALRVNPNDELMWNRLGASLANSNRSEEAIQAYHRALQLKPSFVRARYNLAVSSMNIGCFKEAAGYLLSVLSMHEVNTNNKKGDVGSLLNTYNDTVIETLKRVFIAMNRDDLLQEVKPGMDLKRFKGEFSF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MDVGSCSV
-------CCCCCCCC		9.4517550898
6Ubiquitination--MDVGSCSVGNNPL
--CCCCCCCCCCCHH		2.92PubMed
18UbiquitinationNPLAQLHKHTQQNKS
CHHHHHHHHHHHCCC		57.87PubMed
24UbiquitinationHKHTQQNKSLQFNQK
HHHHHHCCCCCCHHH		48.48PubMed
46UbiquitinationSPLQGTNKPGISEAF
CCCCCCCCCCCCHHH		44.4523749301
61PhosphorylationISNVNAISQENMANM
HHHHHHCCHHHHHHH		29.0917550898
81AcetylationGEPLIDDKRRMEIGP
CCCCCCCHHHCCCCC		37.8524489116
112UbiquitinationSANPTQIKGVNDISH
CCCCCCCCCCCCHHH		47.1717644757
140PhosphorylationRNADTGNSEKAWQRG
CCCCCCCCHHHHHCC		41.6529734811
180PhosphorylationLSGSRLQSPAFMNQQ
CCCCCCCCHHHHCCC		23.8427214570
216PhosphorylationEKLEKEVSENLDIND
HHHHHHHHHCCCCCH		23.1221551504
232PhosphorylationIEKEENVSEVEQNKP
HHHHCCHHHHHHCCC		47.7222369663
241PhosphorylationVEQNKPETVEKEEGV
HHHCCCCCCCCCCCC		42.3622369663
266UbiquitinationEVWDSIHKDAEEVLP
HHHHHHHHCHHHHCC		57.8917644757
289UbiquitinationNLGEDYLKYLGGRVN
CCCHHHHHHHCCCCC		32.0017644757
362UbiquitinationLVQTQNEKELNGISA
CCCCCCHHHHCHHHH		75.0517644757
375UbiquitinationSALEECLKLDPKNLE
HHHHHHHCCCHHHHH		63.6017644757
379UbiquitinationECLKLDPKNLEAMKT
HHHCCCHHHHHHHHH		74.0517644757
406UbiquitinationSAFTMLDKWAETKYP
HHHHHHHHHHHHCCH		44.3217644757
411UbiquitinationLDKWAETKYPEIWSR
HHHHHHHCCHHHHHH		50.7617644757
420UbiquitinationPEIWSRIKQQDDKFQ
HHHHHHHHHCCHHHH		40.5717644757
425UbiquitinationRIKQQDDKFQKEKGF
HHHHCCHHHHHHCCC		58.9717644757
428UbiquitinationQQDDKFQKEKGFTHI
HCCHHHHHHCCCCCC		65.6117644757
521UbiquitinationYHRALQLKPSFVRAR
HHHHHHCCHHHHHHH		26.1717644757
562UbiquitinationHEVNTNNKKGDVGSL
HHCCCCCCCCCHHHH		61.2717644757
563UbiquitinationEVNTNNKKGDVGSLL
HCCCCCCCCCHHHHH		63.5717644757
582UbiquitinationDTVIETLKRVFIAMN
HHHHHHHHHHHHHCC		54.6717644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PEX5_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
6Cubiquitylation

17550898
18Kubiquitylation

17550898
24Kubiquitylation

17550898
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PEX5_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PEX14_YEASTPEX14physical
9312008
ACOX_YEASTPOX1physical
11967269
ECI1_YEASTECI1physical
11302517
PEX13_YEASTPEX13physical
15456864
PEX14_YEASTPEX14physical
15456864
PEX17_YEASTPEX17physical
15456864
PEX12_YEASTPEX12physical
15456864
PEX10_YEASTPEX10physical
15456864
CACP_YEASTCAT2physical
7628448
MDHP_YEASTMDH3physical
11967269
PEX14_YEASTPEX14physical
16849337
PEX13_YEASTPEX13physical
16849337
PEX8_YEASTPEX8physical
16849337
MDHP_YEASTMDH3physical
16849337
PEX17_YEASTPEX17physical
16849337
PEX10_YEASTPEX10physical
16849337
PEX12_YEASTPEX12physical
16849337
PEX3_YEASTPEX3physical
16849337
MDHP_YEASTMDH3physical
11154700
F16P_YEASTFBP1physical
16007078
PEX11_YEASTPEX11physical
16007078
DEP1_YEASTDEP1genetic
20093466
BEM1_YEASTBEM1genetic
20093466
ODPB_YEASTPDB1genetic
20093466
SUL1_YEASTSUL1genetic
20093466
EMI1_YEASTEMI1genetic
20093466
ODPA_YEASTPDA1genetic
20093466
IES1_YEASTIES1genetic
20093466
PUS3_YEASTDEG1genetic
20093466
ATG1_YEASTATG1genetic
20093466
CGR1_YEASTCGR1genetic
20093466
PEF1_YEASTPEF1genetic
20093466
SERB_YEASTSER2genetic
20093466
LPLA_YEASTAIM22genetic
20093466
MPCP_YEASTMIR1genetic
20093466
VPS9_YEASTVPS9genetic
20093466
BUL1_YEASTBUL1genetic
20093466
TGL3_YEASTTGL3genetic
20093466
ATG3_YEASTATG3genetic
20093466
RM50_YEASTMRPL50genetic
20093466
IRA2_YEASTIRA2genetic
20093466
LPX1_YEASTLPX1genetic
20093466
SYH1_YEASTSYH1genetic
20093466
HOS1_YEASTHOS1genetic
20093466
PEX5_YEASTPEX5physical
12876220
UBC4_YEASTUBC4physical
17550898
UBI4P_YEASTUBI4physical
25162638
FAT2_YEASTPCS60physical
26359497
TGL3_YEASTTGL3genetic
27708008
LCB2_YEASTLCB2genetic
27708008
MOB2_YEASTMOB2genetic
27708008
TIM14_YEASTPAM18genetic
27708008
ETR1_YEASTETR1genetic
27708008
ODPB_YEASTPDB1genetic
27708008
CEM1_YEASTCEM1genetic
27708008
ODPA_YEASTPDA1genetic
27708008
VAM7_YEASTVAM7genetic
27708008
PEF1_YEASTPEF1genetic
27708008
NPR3_YEASTNPR3genetic
27708008
HTD2_YEASTHTD2genetic
27708008
LPLA_YEASTAIM22genetic
27708008
BCK1_YEASTBCK1genetic
27708008
SDHB_YEASTSDH2genetic
27708008
PFD6_YEASTYKE2genetic
27708008
VPS9_YEASTVPS9genetic
27708008
ATG3_YEASTATG3genetic
27708008
SDHF2_YEASTSDH5genetic
27708008
MSN1_YEASTMSN1genetic
27708008
LPX1_YEASTLPX1genetic
27708008
FABD_YEASTMCT1genetic
27708008
KPYK2_YEASTPYK2genetic
27708008
SYH1_YEASTSYH1genetic
27708008
CUP9_YEASTCUP9genetic
27708008
UBA3_YEASTUBA3genetic
27708008
PEX13_YEASTPEX13physical
27823812
PEX17_YEASTPEX17physical
27823812
PEX14_YEASTPEX14physical
27823812
PEX6_YEASTPEX6physical
29321502
PEX1_YEASTPEX1physical
29321502
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PEX5_YEAST

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"A conserved cysteine is essential for Pex4p-dependent ubiquitinationof the peroxisomal import receptor Pex5p.";
Williams C., van den Berg M., Sprenger R.R., Distel B.;
J. Biol. Chem. 282:22534-22543(2007).
Cited for: ACETYLATION AT MET-1, UBIQUITINATION AT CYS-6; LYS-18 AND LYS-24, MASSSPECTROMETRY, AND MUTAGENESIS OF CYS-6; LYS-18 AND LYS-24.
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, AND MASSSPECTROMETRY.
Ubiquitylation
ReferencePubMed
"A conserved cysteine is essential for Pex4p-dependent ubiquitinationof the peroxisomal import receptor Pex5p.";
Williams C., van den Berg M., Sprenger R.R., Distel B.;
J. Biol. Chem. 282:22534-22543(2007).
Cited for: ACETYLATION AT MET-1, UBIQUITINATION AT CYS-6; LYS-18 AND LYS-24, MASSSPECTROMETRY, AND MUTAGENESIS OF CYS-6; LYS-18 AND LYS-24.

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