HOS1_YEAST - dbPTM
HOS1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HOS1_YEAST
UniProt AC Q12214
Protein Name Histone deacetylase HOS1
Gene Name HOS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 470
Subcellular Localization Nucleus.
Protein Description Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity)..
Protein Sequence MSKLVISTSIFQSQVADLLPCNNHQKSQLTYSLINAYDLLQHFDEVLTFPYARKDDLLEFHSKSYIDYLINGRFNKMMAQDVNNPMVESKWSELSELADNWNEKIDYNPSQDLQRFTTRENLYNYYLNHSQALENNMDCINNSEVPTNDKPTDTYILNSETKQYNLEGDCPIFSYLPMYCQVITGATLNLLDHLSPTERLIGINWDGGRHHAFKQRASGFCYINDVVLLIQRLRKAKLNKITYVDFDLHHGDGVEKAFQYSKQIQTISVHLYEPGFFPGTGSLSDSRKDKNVVNIPLKHGCDDNYLELIASKIVNPLIERHEPEALIIECGGDGLLGDRFNEWQLTIRGLSRIIINIMKSYPRAHIFLLGGGGYNDLLMSRFYTYLTWCVTKQFSNLRCGDNNSFQIDPFDVCDGDDSEQFIREHDLVEMYNEENYQYWIYEMEGSSRMKMLRNDNKDRDMVELMKFYEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
110PhosphorylationEKIDYNPSQDLQRFT
HCCCCCCCHHHHHHH		32.4627214570
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HOS1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HOS1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HOS1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TUP1_YEASTTUP1physical
14525981
CYC8_YEASTCYC8physical
14525981
ZRT1_YEASTZRT1genetic
17314980
SSN3_YEASTSSN3genetic
17314980
BUB3_YEASTBUB3genetic
17314980
GET2_YEASTGET2genetic
17314980
LSM7_YEASTLSM7genetic
17314980
SAC1_YEASTSAC1genetic
17314980
CTR9_YEASTCTR9genetic
17314980
MED2_YEASTMED2genetic
17314980
YML9_YEASTYML119Wgenetic
17314980
BDF1_YEASTBDF1genetic
18676811
LTE1_YEASTLTE1genetic
18676811
PML39_YEASTPML39genetic
18676811
RSC1_YEASTRSC1genetic
18676811
SPEE_YEASTSPE3genetic
18676811
WHI5_YEASTWHI5physical
19823668
FUN14_YEASTFUN14genetic
20093466
RS8A_YEASTRPS8Agenetic
20093466
RS8B_YEASTRPS8Agenetic
20093466
MNN2_YEASTMNN2genetic
20093466
SEC66_YEASTSEC66genetic
20093466
MBA1_YEASTMBA1genetic
20093466
AIM4_YEASTAIM4genetic
20093466
PEX19_YEASTPEX19genetic
20093466
PEX5_YEASTPEX5genetic
20093466
RPOM_YEASTRPO41genetic
20093466
PEX8_YEASTPEX8genetic
20093466
PEX13_YEASTPEX13genetic
20093466
SSO2_YEASTSSO2genetic
20093466
CIK1_YEASTCIK1genetic
20093466
SWS2_YEASTSWS2genetic
20093466
SMC3_YEASTSMC3physical
20797861
ECO1_YEASTECO1genetic
20832721
SMC3_YEASTSMC3physical
20832720
SIN3_YEASTSIN3physical
22543816
GIC1_YEASTGIC1genetic
22579291
KSP1_YEASTKSP1genetic
22579291
SLG1_YEASTSLG1genetic
22579291
PUT3_YEASTPUT3genetic
22579291
ATC2_YEASTPMC1genetic
22579291
COPA_YEASTCOP1genetic
22579291
SRO77_YEASTSRO77genetic
22579291
AVL9_YEASTAVL9genetic
22579291
TVP23_YEASTTVP23genetic
22579291
GYP2_YEASTMDR1genetic
22579291
MKAR_YEASTIFA38genetic
22579291
TPC1_YEASTTPC1genetic
22579291
MDM38_YEASTMDM38genetic
22579291
ITR1_YEASTITR1genetic
22579291
ADH4_YEASTADH4genetic
22579291
NDH1_YEASTNDE1genetic
22579291
ODC1_YEASTODC1genetic
22579291
FOL1_YEASTFOL1genetic
22579291
NUP49_YEASTNUP49genetic
22579291
HEK2_YEASTHEK2genetic
22579291
REG1_YEASTREG1genetic
22579291
YHH7_YEASTYSC83genetic
22579291
MPC2_YEASTMPC2genetic
22579291
YIF5_YEASTYIL055Cgenetic
22579291
SET4_YEASTSET4genetic
22579291
FUN14_YEASTFUN14genetic
27708008
FLO1_YEASTFLO1genetic
27708008
YBF9_YEASTYBL059Wgenetic
27708008
ECM8_YEASTECM8genetic
27708008
SEC66_YEASTSEC66genetic
27708008
MBA1_YEASTMBA1genetic
27708008
AIM4_YEASTAIM4genetic
27708008
PEX19_YEASTPEX19genetic
27708008
UME6_YEASTUME6genetic
27708008
PEX5_YEASTPEX5genetic
27708008
MRM2_YEASTMRM2genetic
27708008
MED5_YEASTNUT1genetic
27708008
PEX8_YEASTPEX8genetic
27708008
DAL81_YEASTDAL81genetic
27708008
CTK1_YEASTCTK1genetic
27708008
FRA1_YEASTFRA1genetic
27708008
RU2A_YEASTLEA1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HOS1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-110, AND MASSSPECTROMETRY.

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