GIC1_YEAST - dbPTM
GIC1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GIC1_YEAST
UniProt AC P38785
Protein Name GTPase-interacting component 1
Gene Name GIC1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 314
Subcellular Localization Bud neck. Bud tip. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Concentrated at the incipient bud site of unbudded cells, at the bud tip and mother-bud neck of budded cells, and at cortical sites on large-budded cells that may delimit future bud
Protein Description Required for cell size and shape control, bud site selection, bud emergence, actin cytoskeletal organization, mitotic spindle orientation/positioning, and mating projection formation in response to mating pheromone..
Protein Sequence MTEGKRLQQMELPQMKSIWIDEDQEMEKLYGFQVRQRFMNGPSTDSDEDADEDLGIVLVDSKKLALPNKNNIKLPPLPNYMTINPNINSNHKSLTNKKKNFLGMFKKKDLLSRRHGSAKTAKQSSISTPFDFHHISHANGKREDNPLESHEEKHDVESLVKFTSLAPQPRPDSNVSSKYSNVVMNDSSRIVSSSTIATTMDSHHDGNETNNTPNGNKQLDSPTDLEMTLEDLRNYTFPSVLGDSVSEKTNPSSPSVSSFSGKFKPRELSALHTPELGNCFNVDQSLNSPGNRISVDDVLKFYYQCSETSTPRNT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
46PhosphorylationMNGPSTDSDEDADED
HCCCCCCCCCCCCCC		42.8821440633
158PhosphorylationEEKHDVESLVKFTSL
HHHHCHHHHHHHHHC		38.0121440633
173PhosphorylationAPQPRPDSNVSSKYS
CCCCCCCCCCCHHCC		41.6421551504
176PhosphorylationPRPDSNVSSKYSNVV
CCCCCCCCHHCCCEE		25.9321551504
187PhosphorylationSNVVMNDSSRIVSSS
CCEECCCCCCEEECC		19.2625005228
192PhosphorylationNDSSRIVSSSTIATT
CCCCCEEECCCEEEE		19.0523749301
221PhosphorylationNGNKQLDSPTDLEMT
CCCCCCCCCCCHHCH		37.9921440633
246PhosphorylationSVLGDSVSEKTNPSS
HHHCCCCCCCCCCCC		37.0127017623
252PhosphorylationVSEKTNPSSPSVSSF
CCCCCCCCCCCHHHC		57.8827017623
253PhosphorylationSEKTNPSSPSVSSFS
CCCCCCCCCCHHHCC		23.5821551504
255PhosphorylationKTNPSSPSVSSFSGK
CCCCCCCCHHHCCCC		36.2621551504
257PhosphorylationNPSSPSVSSFSGKFK
CCCCCCHHHCCCCCC		29.9721551504
258PhosphorylationPSSPSVSSFSGKFKP
CCCCCHHHCCCCCCC		22.6727017623
306PhosphorylationLKFYYQCSETSTPRN
HHHHHHHHCCCCCCC		28.5221440633
310PhosphorylationYQCSETSTPRNT---
HHHHCCCCCCCC---		33.4221551504
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GIC1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GIC1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GIC1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BFA1_YEASTBFA1physical
14734533
BUB2_YEASTBUB2physical
14734533
CDC14_YEASTCDC14physical
14734533
TEM1_YEASTTEM1physical
14734533
CDC42_YEASTCDC42physical
14734533
CDC42_YEASTCDC42physical
9367979
BEM4_YEASTBEM4physical
11489916
BUB2_YEASTBUB2physical
11489916
CDC12_YEASTCDC12physical
11489916
CLA4_YEASTCLA4physical
11489916
DFG5_YEASTDFG5physical
11489916
GIC1_YEASTGIC1physical
11489916
GIC2_YEASTGIC2physical
11489916
CYK2_YEASTHOF1physical
11489916
STE50_YEASTSTE50physical
11489916
RRP14_YEASTRRP14physical
11489916
CSM1_YEASTCSM1physical
11489916
ZDS1_YEASTZDS1physical
11489916
ZDS2_YEASTZDS2physical
11489916
PCL1_YEASTPCL1genetic
14688790
PCL2_YEASTPCL2genetic
14688790
CDC5_YEASTCDC5genetic
14734533
GIC2_YEASTGIC2genetic
9367980
CDC11_YEASTCDC11physical
16371506
CDC12_YEASTCDC12physical
16371506
MLF3_YEASTMLF3genetic
16816427
VHS2_YEASTVHS2genetic
16816427
GIC2_YEASTGIC2genetic
9367979
BEM2_YEASTBEM2genetic
9367979
SSD1_YEASTSSD1genetic
9367979
CDC42_YEASTCDC42genetic
9367979
CLA4_YEASTCLA4genetic
9367979
CDC24_YEASTCDC24genetic
9367979
GIC2_YEASTGIC2genetic
17914055
HSP71_YEASTSSA1physical
19536198
SSB1_YEASTSSB1physical
19536198
GIC2_YEASTGIC2genetic
12622721
RSR1_YEASTRSR1genetic
12622721
BUD2_YEASTBUD2genetic
12622721
BUD5_YEASTBUD5genetic
12622721
CDC42_YEASTCDC42genetic
9367980
RSR1_YEASTRSR1genetic
16816427
AXL2_YEASTAXL2genetic
16816427
BNI1_YEASTBNI1genetic
16816427
STE20_YEASTSTE20genetic
16816427
CG12_YEASTCLN2genetic
16816427
CYC8_YEASTCYC8genetic
16816427
TUP1_YEASTTUP1genetic
16816427
SKG6_YEASTSKG6genetic
16816427
TOS2_YEASTTOS2genetic
16816427
MSB2_YEASTMSB2genetic
16816427
MSB1_YEASTMSB1genetic
16816427
RSR1_YEASTRSR1genetic
20587777
GYP3_YEASTMSB3genetic
10679030
MSB4_YEASTMSB4genetic
10679030
CDC11_YEASTCDC11physical
23906065
H2A2_YEASTHTA2physical
27301280
H2B2_YEASTHTB2physical
27301280
GNA1_YEASTGNA1genetic
27708008
STS1_YEASTSTS1genetic
27708008
KTHY_YEASTCDC8genetic
27708008
CDC11_YEASTCDC11genetic
27708008
NTR2_YEASTNTR2genetic
27708008
PRP19_YEASTPRP19genetic
27708008
SSL1_YEASTSSL1genetic
27708008
SEC22_YEASTSEC22genetic
27708008
RPN7_YEASTRPN7genetic
27708008
CDC10_YEASTCDC10physical
24286829
CDC42_YEASTCDC42physical
24286829
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GIC1_YEAST

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Related Literatures of Post-Translational Modification

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