ZDS2_YEAST - dbPTM
ZDS2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZDS2_YEAST
UniProt AC P54786
Protein Name Protein ZDS2
Gene Name ZDS2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 942
Subcellular Localization
Protein Description Acts as a negative regulator of polarized growth via an alternative mechanism to ZDS1. In heat-stressed cells appears to play a role in localizing BCY1 to the cytoplasm. Seems to interact with, and down-regulate, CDC42. Also acts as a suppressor of PKC1. May act as an integration point for distinct signaling pathways helping to maintain a balance among these different pathways..
Protein Sequence MVLMEDMQNKDGHNTVENSSGGTDSNNNIQMRRMRKTQLSKKELFEKRKSDVLIAAKSLDTEIQNVKNLKRLSIGSMDLVIDPELEFKVNSRNSYSSDSSKESLQESLHEENIIRSEQKEEQGSEDNDAYEEGDATNVDDSIDITQTEYLHDEETLEKEKIIRNASSSTSSSARVTSRNRRLSGVKTLAHDVVLDVENDHDSKMVDLTQNLLWVPADQHPNVKPENYLELIQDTLQNIQISTNQDIDENKLELGNNHVISNRKRTGSVVRRPSRLKTSYTKFDDEPPLADKPQEGEIQVDKRISSSDIKTIRSVSLKEITEELTKISNNAGLTDSDAVTLARSLSMSGSFTNESLHLNGNHTENDNEFASNMFNETGLTIPERSSLRRSKFNTYKIRLEGSSLPQAVKLNSLMNIQTNDNRRSASSPASYTQVPQEQASLNDFHEIFDHYRRTSTDWSTENEKYVDSTNYYSDEEDLTHASISQESSLLSTDSSNNSVLIKPHNTGSMISEKLDQHVSSSEKSNTNNSEANHGWSWLNSSNGSLNANEQTYQQLTDDEDDEECVDNEKADFVNLSVSRRAKSTKRASERINHSKNRHSPIFQIHSEEAKSVVITPSVVSSSESQPSKPTAPAVVEKKVELPTDTQASTHKKNSLEKRLAKLFKRKQHNGTCKSDVKVIKKSVKKELKKKASHSSLSKFRKSPKKKPQEAEVERPSSPTKTITTEDIDTASVIEPEVRSSNASTLLPDSHTSHSSEFVVETISELDGDDSFDISGGDVNYDVEVHSSISRDTTAGLEEDIGAEREDNTSPTAPQISTLPPRKLTFEDVVKPDYSNAPIKFTDSAFGFPLPMITNSTVIMFDHRLGINVERAIYRLSHLKLSDPGRELRQQVLLSNFMYSYLNLVNHTLYMEQVGTGDIAFNGDSALGMMDKNDSDGTILIPDI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
15PhosphorylationQNKDGHNTVENSSGG
CCCCCCCCCCCCCCC		24.4221551504
50PhosphorylationELFEKRKSDVLIAAK
HHHHHHHHHHEEEEC		36.6617330950
73PhosphorylationVKNLKRLSIGSMDLV
HHCCCCCCCCCEEEE		29.0121440633
76PhosphorylationLKRLSIGSMDLVIDP
CCCCCCCCEEEEECC		13.8821440633
96PhosphorylationVNSRNSYSSDSSKES
ECCCCCCCCCCCHHH		27.7319779198
167PhosphorylationKIIRNASSSTSSSAR
HHHHCCCCCCCCCHH		34.9117563356
172PhosphorylationASSSTSSSARVTSRN
CCCCCCCCHHHHCCC		21.6217563356
304PhosphorylationIQVDKRISSSDIKTI
CEECCCCCHHHCCHH		28.0223749301
305PhosphorylationQVDKRISSSDIKTIR
EECCCCCHHHCCHHH		29.6521440633
306PhosphorylationVDKRISSSDIKTIRS
ECCCCCHHHCCHHHE		36.2423749301
313PhosphorylationSDIKTIRSVSLKEIT
HHCCHHHEEEHHHHH		16.5322369663
315PhosphorylationIKTIRSVSLKEITEE
CCHHHEEEHHHHHHH		34.6622369663
320PhosphorylationSVSLKEITEELTKIS
EEEHHHHHHHHHHHH		25.2129688323
324PhosphorylationKEITEELTKISNNAG
HHHHHHHHHHHCCCC		29.6129688323
351PhosphorylationLSMSGSFTNESLHLN
HHCCCCCCCCEEEEC		39.5119779198
362PhosphorylationLHLNGNHTENDNEFA
EEECCCCCCCCCHHH		40.2519779198
423PhosphorylationQTNDNRRSASSPASY
CCCCCCCCCCCCCCC		29.3019779198
426PhosphorylationDNRRSASSPASYTQV
CCCCCCCCCCCCCCC		24.9719779198
453PhosphorylationIFDHYRRTSTDWSTE
HHHHHHCCCCCCCCC		27.2927214570
454PhosphorylationFDHYRRTSTDWSTEN
HHHHHCCCCCCCCCC		23.6625704821
455PhosphorylationDHYRRTSTDWSTENE
HHHHCCCCCCCCCCC		40.6619779198
507PhosphorylationIKPHNTGSMISEKLD
ECCCCCCCHHHHHHH		15.7621551504
510PhosphorylationHNTGSMISEKLDQHV
CCCCCHHHHHHHHHH		21.7521551504
575PhosphorylationKADFVNLSVSRRAKS
CCCEEEEHHHHHHHH		16.9128889911
577PhosphorylationDFVNLSVSRRAKSTK
CEEEEHHHHHHHHHH		16.8128889911
598PhosphorylationNHSKNRHSPIFQIHS
CCCCCCCCCCEEECC		19.2219823750
605PhosphorylationSPIFQIHSEEAKSVV
CCCEEECCHHCCEEE		38.4719823750
610PhosphorylationIHSEEAKSVVITPSV
ECCHHCCEEEECHHH		28.7628889911
614PhosphorylationEAKSVVITPSVVSSS
HCCEEEECHHHHCCC		9.6328152593
616PhosphorylationKSVVITPSVVSSSES
CEEEECHHHHCCCCC		26.8828152593
619PhosphorylationVITPSVVSSSESQPS
EECHHHHCCCCCCCC		26.4523749301
621PhosphorylationTPSVVSSSESQPSKP
CHHHHCCCCCCCCCC		33.4928889911
623PhosphorylationSVVSSSESQPSKPTA
HHHCCCCCCCCCCCC		49.7127017623
629PhosphorylationESQPSKPTAPAVVEK
CCCCCCCCCCEEEEE		49.3527017623
647PhosphorylationLPTDTQASTHKKNSL
CCCCCCHHHHCCCHH		22.6428889911
648PhosphorylationPTDTQASTHKKNSLE
CCCCCHHHHCCCHHH		40.5028889911
691PhosphorylationKELKKKASHSSLSKF
HHHHHHHCCHHHHHH		32.5519823750
693PhosphorylationLKKKASHSSLSKFRK
HHHHHCCHHHHHHHC		30.4019823750
694PhosphorylationKKKASHSSLSKFRKS
HHHHCCHHHHHHHCC		31.1019823750
715PhosphorylationEAEVERPSSPTKTIT
CCCCCCCCCCCCEEE		55.9920377248
716PhosphorylationAEVERPSSPTKTITT
CCCCCCCCCCCEEEH		38.9919823750
718PhosphorylationVERPSSPTKTITTED
CCCCCCCCCEEEHHH		42.6520377248
722PhosphorylationSSPTKTITTEDIDTA
CCCCCEEEHHHCCHH		29.3927017623
723PhosphorylationSPTKTITTEDIDTAS
CCCCEEEHHHCCHHH		28.0127017623
730PhosphorylationTEDIDTASVIEPEVR
HHHCCHHHCCCCHHC		26.2225704821
791PhosphorylationHSSISRDTTAGLEED
ECCCCCCCCCCCHHH		19.8928132839
792PhosphorylationSSISRDTTAGLEEDI
CCCCCCCCCCCHHHC		24.0228889911
807PhosphorylationGAEREDNTSPTAPQI
CCCCCCCCCCCCCCC		48.7027017623
808PhosphorylationAEREDNTSPTAPQIS
CCCCCCCCCCCCCCC		26.8927017623
840PhosphorylationSNAPIKFTDSAFGFP
CCCCEEECCCCCCCC		24.8419779198
852PhosphorylationGFPLPMITNSTVIMF
CCCCCEECCCEEEEE		19.5019779198
880PhosphorylationRLSHLKLSDPGRELR
HHHCCCCCCCCHHHH		39.9228889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZDS2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZDS2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZDS2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
2ABA_YEASTCDC55physical
11805826
2AAA_YEASTTPD3physical
11805826
BLM10_YEASTBLM10physical
11805826
PP2A2_YEASTPPH22physical
11805826
PSA7_YEASTPRE10physical
11805826
RAP1_YEASTRAP1physical
10398844
SIR2_YEASTSIR2physical
10398844
SIR3_YEASTSIR3physical
10398844
SIR4_YEASTSIR4physical
10398844
ZDS1_YEASTZDS1physical
11489916
BNI1_YEASTBNI1physical
11489916
CDC11_YEASTCDC11physical
11489916
CLA4_YEASTCLA4physical
11489916
KPC1_YEASTPKC1physical
11489916
SPR6_YEASTSPR6physical
11489916
YEC3_YEASTYEL023Cphysical
11489916
DSE1_YEASTDSE1physical
11489916
RRP14_YEASTRRP14physical
11489916
ZDS2_YEASTZDS2physical
11489916
2ABA_YEASTCDC55physical
16554755
2ABA_YEASTCDC55physical
16429126
2AAA_YEASTTPD3physical
16429126
PP2A2_YEASTPPH22physical
16429126
2ABA_YEASTCDC55physical
11283351
BEM1_YEASTBEM1genetic
19269370
KCS1_YEASTKCS1genetic
19269370
BUB1_YEASTBUB1genetic
19269370
PTK2_YEASTPTK2genetic
19269370
ZDS1_YEASTZDS1genetic
19269370
OCA1_YEASTOCA1genetic
19269370
KPR5_YEASTPRS5genetic
19269370
2ABA_YEASTCDC55physical
18762578
2AAA_YEASTTPD3physical
18762578
KPC1_YEASTPKC1physical
20980617
2ABA_YEASTCDC55physical
20980617
PP2A1_YEASTPPH21physical
20980617
2ABA_YEASTCDC55genetic
20980617
2AAA_YEASTTPD3physical
20980617
ZAP1_YEASTZAP1genetic
20959818
URE2_YEASTURE2genetic
20959818
AFT1_YEASTAFT1genetic
20959818
AATC_YEASTAAT2genetic
20959818
ZDS1_YEASTZDS1genetic
20959818
HMO1_YEASTHMO1genetic
20959818
WAR1_YEASTWAR1genetic
20959818
2ABA_YEASTCDC55genetic
21536748
SWE1_YEASTSWE1genetic
21536748
LTE1_YEASTLTE1genetic
21536748
SWE1_YEASTSWE1genetic
14623082
IGO2_YEASTIGO2genetic
24800822
TIM22_YEASTTIM22genetic
27708008
CDC1_YEASTCDC1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
TAF6_YEASTTAF6genetic
27708008
SMD1_YEASTSMD1genetic
27708008
BRL1_YEASTBRL1genetic
27708008
RPF1_YEASTRPF1genetic
27708008
NU192_YEASTNUP192genetic
27708008
ARP4_YEASTARP4genetic
27708008
RFC2_YEASTRFC2genetic
27708008
MED14_YEASTRGR1genetic
27708008
CFT2_YEASTCFT2genetic
27708008
SC61A_YEASTSEC61genetic
27708008
MED11_YEASTMED11genetic
27708008
ROT1_YEASTROT1genetic
27708008
CH10_YEASTHSP10genetic
27708008
OST2_YEASTOST2genetic
27708008
RPB2_YEASTRPB2genetic
27708008
PGTB2_YEASTBET2genetic
27708008
RHO1_YEASTRHO1genetic
26728856
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZDS2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-167; SER-172 ANDSER-716, AND MASS SPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-716, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, AND MASSSPECTROMETRY.

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