KCS1_YEAST - dbPTM
KCS1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KCS1_YEAST
UniProt AC Q12494
Protein Name Inositol hexakisphosphate kinase 1
Gene Name KCS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1050
Subcellular Localization Cytoplasm .
Protein Description Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Involved in phosphate regulation and polyphosphate accumulation. Required for resistance to salt stress, cell wall integrity, vacuole morphogenesis, and telomere maintenance..
Protein Sequence MDTSHEIHDKIPDTLREQQQHLRQKESEGCITTLKDLNVPETKKLSSVLHGRKASTYLRIFRDDECLADNNNGVDSNNGGSVTCADKITRSEATPKSVPEGLQVSEKKNNPDTLSSSLSSFILSNHEEPAIKPNKHVAHRNNITETGQGSGEDIAKQQSHQPQVLHHQTSLKPIQNVDEGCISPKSTYQESLHGISEDLTLKPVSSATYYPHKSKADSGYEEKDKMENDIDTIQPATINCASGIATLPSSYNRHTFKVKTYSTLSQSLRQENVNNRSNEKKPQQFVPHSESIKEKPNTFEQDKEGEQADEEEDEGDNEHREYPLAVELKPFTNRVGGHTAIFRFSKRAVCKALVNRENRWYENIELCHKELLQFMPRYIGVLNVRQHFQSKDDFLSDLDQENNGKNDTSNENKDIEVNHNNNDDIALNTEPTGTPLTHIHSFPLEHSSRQVLEKEHPEIESVHPHVKRSLSSSNQPSLLPEVVLNDNRHIIPESLWYKYSDSPNSAPNDSYFSSSSSHNSCSFGERGNTNKLKRRDSGSTMINTELKNLVIREVFAPKCFRRKRNSNTTTMGNHNARLGSSPSFLTQKSRASSHDASNTSMKTLGDSSSQASLQMDDSKVNPNLQDPFLKKSLHEKISNALDGSHSVMDLKQFHKNEQIKHKNSFCNSLSPILTATNSRDDGEFATSPNYISNAQDGVFDMDEDTGNETINMDNHGCHLDSGKNMIIKSLAYNVSNDYSHHDIESITFEETSHTIVSKFILLEDLTRNMNKPCALDLKMGTRQYGVDAKRAKQLSQRAKCLKTTSRRLGVRICGLKVWNKDYYITRDKYFGRRVKVGWQFARVLARFLYDGKTIESLIRQIPRLIKQLDTLYSEIFNLKGYRLYGASLLLMYDGDANKSNSKRKKAANVKVNLIDFARCVTKEDAMECMDKFRIPPKSPNIEDKGFLRGVKSLRFYLLLIWNYLTSDMPLIFDEVEMNDMISEEADSNSFTSATGSKINFNSKWDWLDEFDKEDEEMYNDPNSKLRQKWRKYELIFDAEPRYNDDAQVSD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10AcetylationTSHEIHDKIPDTLRE
CHHHHHHHCCHHHHH		41.8124489116
27PhosphorylationQHLRQKESEGCITTL
HHHHHHHHCCCCCHH		46.4522369663
55PhosphorylationVLHGRKASTYLRIFR
HHCCCCCCCEEEEEC		22.1821440633
56PhosphorylationLHGRKASTYLRIFRD
HCCCCCCCEEEEECC		31.2823749301
57PhosphorylationHGRKASTYLRIFRDD
CCCCCCCEEEEECCC		7.4723749301
89PhosphorylationVTCADKITRSEATPK
EECHHCEECCCCCCC		33.6124961812
91PhosphorylationCADKITRSEATPKSV
CHHCEECCCCCCCCC		23.9624961812
94PhosphorylationKITRSEATPKSVPEG
CEECCCCCCCCCCCC		27.4824961812
97PhosphorylationRSEATPKSVPEGLQV
CCCCCCCCCCCCCCC		44.0725752575
113PhosphorylationEKKNNPDTLSSSLSS
CCCCCCCHHHHHHHH		29.7819823750
115PhosphorylationKNNPDTLSSSLSSFI
CCCCCHHHHHHHHHH		21.7019823750
116PhosphorylationNNPDTLSSSLSSFIL
CCCCHHHHHHHHHHH		38.1121440633
117PhosphorylationNPDTLSSSLSSFILS
CCCHHHHHHHHHHHH		28.9725752575
119PhosphorylationDTLSSSLSSFILSNH
CHHHHHHHHHHHHCC		25.7528889911
120PhosphorylationTLSSSLSSFILSNHE
HHHHHHHHHHHHCCC		22.9221440633
124PhosphorylationSLSSFILSNHEEPAI
HHHHHHHHCCCCCCC		31.1824961812
144PhosphorylationVAHRNNITETGQGSG
CCHHCCCCCCCCCCH		29.6222369663
146PhosphorylationHRNNITETGQGSGED
HHCCCCCCCCCCHHH		26.5922369663
150PhosphorylationITETGQGSGEDIAKQ
CCCCCCCCHHHHHHH		30.9922369663
170PhosphorylationQVLHHQTSLKPIQNV
CEECCCCCCCCCCCC		28.0321440633
183PhosphorylationNVDEGCISPKSTYQE
CCCCCCCCCCHHHHH		30.2820377248
186PhosphorylationEGCISPKSTYQESLH
CCCCCCCHHHHHHHC		35.4122369663
187PhosphorylationGCISPKSTYQESLHG
CCCCCCHHHHHHHCC		35.0422369663
188PhosphorylationCISPKSTYQESLHGI
CCCCCHHHHHHHCCC		19.8521440633
191PhosphorylationPKSTYQESLHGISED
CCHHHHHHHCCCCCC		15.3322369663
196PhosphorylationQESLHGISEDLTLKP
HHHHCCCCCCCCCCC		29.6522369663
200PhosphorylationHGISEDLTLKPVSSA
CCCCCCCCCCCCCCC		45.0922369663
205PhosphorylationDLTLKPVSSATYYPH
CCCCCCCCCCCCCCC		23.8420377248
206PhosphorylationLTLKPVSSATYYPHK
CCCCCCCCCCCCCCC		25.5120377248
208PhosphorylationLKPVSSATYYPHKSK
CCCCCCCCCCCCCCC		26.0722369663
209PhosphorylationKPVSSATYYPHKSKA
CCCCCCCCCCCCCCC		18.0822369663
210PhosphorylationPVSSATYYPHKSKAD
CCCCCCCCCCCCCCC		8.4322369663
249PhosphorylationSGIATLPSSYNRHTF
CCCCCCCCCCCCCEE		48.8719779198
250PhosphorylationGIATLPSSYNRHTFK
CCCCCCCCCCCCEEE		25.2019779198
251PhosphorylationIATLPSSYNRHTFKV
CCCCCCCCCCCEEEE		22.1319779198
255PhosphorylationPSSYNRHTFKVKTYS
CCCCCCCEEEEEEHH		23.1621551504
259AcetylationNRHTFKVKTYSTLSQ
CCCEEEEEEHHHHHH		42.1924489116
262PhosphorylationTFKVKTYSTLSQSLR
EEEEEEHHHHHHHHH		28.2730377154
265PhosphorylationVKTYSTLSQSLRQEN
EEEHHHHHHHHHHHC		20.1523749301
267PhosphorylationTYSTLSQSLRQENVN
EHHHHHHHHHHHCCC		23.3423749301
289PhosphorylationPQQFVPHSESIKEKP
CCCCCCCCHHHCCCC		27.2821440633
291PhosphorylationQFVPHSESIKEKPNT
CCCCCCHHHCCCCCC		41.8120377248
396PhosphorylationQSKDDFLSDLDQENN
HCCCHHHHHHHHHCC		35.8022369663
432PhosphorylationIALNTEPTGTPLTHI
CEEECCCCCCCCCEE		47.6721440633
434PhosphorylationLNTEPTGTPLTHIHS
EECCCCCCCCCEEEE		20.0121440633
437PhosphorylationEPTGTPLTHIHSFPL
CCCCCCCCEEEECCC		21.7121440633
441PhosphorylationTPLTHIHSFPLEHSS
CCCCEEEECCCCCHH		28.1428889911
454AcetylationSSRQVLEKEHPEIES
HHHHHHHHHCCCHHH		58.1024489116
469PhosphorylationVHPHVKRSLSSSNQP
HCHHHHHHCCCCCCC		27.2122369663
471PhosphorylationPHVKRSLSSSNQPSL
HHHHHHCCCCCCCCC		32.7322369663
472PhosphorylationHVKRSLSSSNQPSLL
HHHHHCCCCCCCCCC		38.3022369663
473PhosphorylationVKRSLSSSNQPSLLP
HHHHCCCCCCCCCCC		35.7922890988
477PhosphorylationLSSSNQPSLLPEVVL
CCCCCCCCCCCEEEE		32.5422890988
494PhosphorylationNRHIIPESLWYKYSD
CCCCCCHHHEEECCC		20.8822369663
499PhosphorylationPESLWYKYSDSPNSA
CHHHEEECCCCCCCC		11.3023749301
500PhosphorylationESLWYKYSDSPNSAP
HHHEEECCCCCCCCC		27.7121440633
502PhosphorylationLWYKYSDSPNSAPND
HEEECCCCCCCCCCC		21.7520377248
505PhosphorylationKYSDSPNSAPNDSYF
ECCCCCCCCCCCCCC		48.7820377248
510PhosphorylationPNSAPNDSYFSSSSS
CCCCCCCCCCCCCCC		34.4221440633
511PhosphorylationNSAPNDSYFSSSSSH
CCCCCCCCCCCCCCC		15.4421440633
513PhosphorylationAPNDSYFSSSSSHNS
CCCCCCCCCCCCCCC		22.5221440633
514PhosphorylationPNDSYFSSSSSHNSC
CCCCCCCCCCCCCCC		25.0819779198
515PhosphorylationNDSYFSSSSSHNSCS
CCCCCCCCCCCCCCC		34.3621440633
516PhosphorylationDSYFSSSSSHNSCSF
CCCCCCCCCCCCCCC		37.2519779198
517PhosphorylationSYFSSSSSHNSCSFG
CCCCCCCCCCCCCCC		28.7419779198
520PhosphorylationSSSSSHNSCSFGERG
CCCCCCCCCCCCCCC		13.0021440633
522PhosphorylationSSSHNSCSFGERGNT
CCCCCCCCCCCCCCC		35.7923749301
537PhosphorylationNKLKRRDSGSTMINT
CCCCCCCCCCCCCCH		32.6022369663
539PhosphorylationLKRRDSGSTMINTEL
CCCCCCCCCCCCHHH		20.8222369663
540PhosphorylationKRRDSGSTMINTELK
CCCCCCCCCCCHHHH		26.1222369663
544PhosphorylationSGSTMINTELKNLVI
CCCCCCCHHHHHHHH		31.6022369663
566PhosphorylationCFRRKRNSNTTTMGN
HHHCCCCCCCCCCCC		39.3219823750
568PhosphorylationRRKRNSNTTTMGNHN
HCCCCCCCCCCCCCC		24.3822890988
569PhosphorylationRKRNSNTTTMGNHNA
CCCCCCCCCCCCCCC		21.0222890988
570PhosphorylationKRNSNTTTMGNHNAR
CCCCCCCCCCCCCCC		22.5022890988
580PhosphorylationNHNARLGSSPSFLTQ
CCCCCCCCCCCHHCC		43.6022369663
581PhosphorylationHNARLGSSPSFLTQK
CCCCCCCCCCHHCCH		23.8222369663
583PhosphorylationARLGSSPSFLTQKSR
CCCCCCCCHHCCHHH		34.5322369663
586PhosphorylationGSSPSFLTQKSRASS
CCCCCHHCCHHHCCC		31.7522890988
589PhosphorylationPSFLTQKSRASSHDA
CCHHCCHHHCCCCCC		24.2217287358
592PhosphorylationLTQKSRASSHDASNT
HCCHHHCCCCCCCCC		27.3917287358
593PhosphorylationTQKSRASSHDASNTS
CCHHHCCCCCCCCCC		25.1319823750
597PhosphorylationRASSHDASNTSMKTL
HCCCCCCCCCCCCCC		46.8517563356
599PhosphorylationSSHDASNTSMKTLGD
CCCCCCCCCCCCCCC		27.9219823750
600PhosphorylationSHDASNTSMKTLGDS
CCCCCCCCCCCCCCC		23.6419823750
603PhosphorylationASNTSMKTLGDSSSQ
CCCCCCCCCCCCCCC		27.6022369663
607PhosphorylationSMKTLGDSSSQASLQ
CCCCCCCCCCCHHHC		30.0522369663
608PhosphorylationMKTLGDSSSQASLQM
CCCCCCCCCCHHHCC		31.0722369663
609PhosphorylationKTLGDSSSQASLQMD
CCCCCCCCCHHHCCC		33.4522369663
612PhosphorylationGDSSSQASLQMDDSK
CCCCCCHHHCCCCCC		16.1122369663
618PhosphorylationASLQMDDSKVNPNLQ
HHHCCCCCCCCCCCC		33.9530377154
638PhosphorylationKSLHEKISNALDGSH
HHHHHHHHHHHCCCC		27.4122890988
644PhosphorylationISNALDGSHSVMDLK
HHHHHCCCCCCCCHH		16.5622369663
646PhosphorylationNALDGSHSVMDLKQF
HHHCCCCCCCCHHHH		22.3422369663
664PhosphorylationEQIKHKNSFCNSLSP
HHHCCCCCCHHHCHH		35.6625704821
668PhosphorylationHKNSFCNSLSPILTA
CCCCCHHHCHHHEEE		31.2528889911
670PhosphorylationNSFCNSLSPILTATN
CCCHHHCHHHEEECC		15.0927738172
676PhosphorylationLSPILTATNSRDDGE
CHHHEEECCCCCCCC		28.6128889911
778AcetylationKPCALDLKMGTRQYG
CCCEEECCCCCCHHC		34.6424489116
1049PhosphorylationYNDDAQVSD------
CCCCCCCCC------		26.0625521595
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KCS1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KCS1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KCS1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BMH2_YEASTBMH2physical
10688190
PP2C1_YEASTPTC1genetic
8601473
BMH2_YEASTBMH2physical
16554755
MLC1_YEASTMLC1physical
16554755
YM54_YEASTYMR196Wphysical
16554755
IMB3_YEASTPSE1physical
16554755
MYO2_YEASTMYO2physical
16554755
INP52_YEASTINP52genetic
19269370
RFA2_YEASTRFA2genetic
19269370
CET1_YEASTCET1genetic
19269370
SSB1_YEASTSSB1physical
19536198
SRS2_YEASTSRS2genetic
21459050
FUS3_YEASTFUS3genetic
21127252
RTG3_YEASTRTG3genetic
21127252
RAD18_YEASTRAD18genetic
21127252
RPN4_YEASTRPN4genetic
21127252
KCC4_YEASTKCC4genetic
21127252
HAL4_YEASTSAT4genetic
21127252
REI1_YEASTREI1genetic
21127252
SWC5_YEASTSWC5genetic
21127252
PRR2_YEASTPRR2genetic
21127252
MRK1_YEASTMRK1genetic
21127252
HCM1_YEASTHCM1genetic
21127252
CSN5_YEASTRRI1genetic
21127252
MBP1_YEASTMBP1genetic
21127252
MRC1_YEASTMRC1genetic
21127252
PHO2_YEASTPHO2genetic
21127252
CYC8_YEASTCYC8genetic
21127252
CDK1_YEASTCDC28genetic
21127252
DCC1_YEASTDCC1genetic
21127252
ISW1_YEASTISW1genetic
21127252
CHK1_YEASTCHK1genetic
21127252
PPAD_YEASTDIA3genetic
21127252
PP2A2_YEASTPPH22genetic
21127252
PP4R2_YEASTPSY4genetic
21127252
KIN82_YEASTKIN82genetic
21127252
HAP3_YEASTHAP3genetic
21127252
PP2A1_YEASTPPH21genetic
21127252
RXT2_YEASTRXT2genetic
21127252
VIP1_YEASTVIP1genetic
22076377
GCR1_YEASTGCR1genetic
22076377
ATG5_YEASTATG5genetic
22889849
KCS1_YEASTKCS1physical
22940862
RS6A_YEASTRPS6Bphysical
22940862
RS6B_YEASTRPS6Bphysical
22940862
RL2A_YEASTRPL2Aphysical
22940862
RL2B_YEASTRPL2Aphysical
22940862
OPI1_YEASTOPI1genetic
23824185
DDP1_YEASTDDP1genetic
25423617
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KCS1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-150; SER-206; TYR-210;SER-396; SER-441; SER-471; SER-472; SER-477; SER-537; SER-581;SER-583; SER-593; SER-609; SER-644; SER-646; SER-664 AND SER-670, ANDMASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-469; SER-471; SER-472;SER-566; SER-597 AND SER-646, AND MASS SPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-537; SER-539; SER-566;SER-589; SER-592 AND SER-593, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-537, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-471; SER-581; SER-589AND SER-644, AND MASS SPECTROMETRY.

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