dbPTM

MRK1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MRK1_YEAST
UniProt AC	P50873
Protein Name	Serine/threonine-protein kinase MRK1
Gene Name	MRK1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	501
Subcellular Localization
Protein Description
Protein Sequence	MTDVLRSLVRKISFNNSDNLQLKHKTSIQSNTALEKKKRKPDTIKKVSDVQVHHTVPNFNNSSEYINDIENLIISKLIDGGKEGIAVDHIEHANISDSKTDGKVANKHENISSKLSKEKVEKMINFDYRYIKTKERTIHKRVYKHDRKTDVDRKNHGGTIDISYPTTEVVGHGSFGVVVTTVIIETNQKVAIKKVLQDRRYKNRELETMKMLCHPNTVGLQYYFYEKDEEDEVYLNLVLDYMPQSLYQRLRHFVNLKMQMPRVEIKFYAYQLFKALNYLHNVPRICHRDIKPQNLLVDPTTFSFKICDFGSAKCLKPDQPNVSYICSRYYRAPELMFGATNYSNQVDVWSSACVIAELLLGKPLFSGESGIDQLVEIIKIMGIPTKDEISGMNPNYEDHVFPNIKPITLAEIFKAEDPDTLDLLTKTLKYHPCERLVPLQCLLSSYFDETKRCDTDTYVKAQNLRIFDFDVETELGHVPLVERPAIEERLKHFVSAPSSSL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	RSLVRKISFNNSDNL HHHHHHHHCCCCCCC	25.59	28889911
17	Phosphorylation	RKISFNNSDNLQLKH HHHHCCCCCCCEEEE	29.04	30377154
98	Phosphorylation	EHANISDSKTDGKVA EECCCCCCCCCCCCC	30.57	28889911
313	Acetylation	ICDFGSAKCLKPDQP ECCCCCCCCCCCCCC	41.62	25381059
323	Phosphorylation	KPDQPNVSYICSRYY CCCCCCHHHHHCCCC	18.54	29136822
324	Phosphorylation	PDQPNVSYICSRYYR CCCCCHHHHHCCCCC	11.15	29136822
327	Phosphorylation	PNVSYICSRYYRAPE CCHHHHHCCCCCCCH	17.48	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MRK1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MRK1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MRK1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MSN2_YEAST	MSN2	genetic	12529445
MCK1_YEAST	MCK1	genetic	12529445
YGK3_YEAST	YGK3	genetic	12529445
PGM1_YEAST	PGM1	genetic	12529445
IPYR_YEAST	IPP1	genetic	19269370
RTK1_YEAST	RTK1	genetic	19269370
YPD1_YEAST	YPD1	genetic	19269370
MNN10_YEAST	MNN10	genetic	19269370
KCC1_YEAST	CMK1	genetic	19269370
SA155_YEAST	SAP155	genetic	19269370
RPN10_YEAST	RPN10	genetic	19269370
CDC5_YEAST	CDC5	genetic	19269370
TCPG_YEAST	CCT3	physical	20489023
AMPL_YEAST	APE1	physical	20489023
MCM4_YEAST	MCM4	physical	20489023
RUVB2_YEAST	RVB2	physical	20489023
SA185_YEAST	SAP185	physical	20489023
DUT_YEAST	DUT1	physical	21460040
ELP2_YEAST	ELP2	physical	21460040
GAL10_YEAST	GAL10	physical	21460040
UBA1_YEAST	UBA1	physical	21460040
YCQ6_YEAST	YCR016W	physical	21460040
PP2C1_YEAST	PTC1	genetic	21127252
HAL4_YEAST	SAT4	genetic	21127252
REI1_YEAST	REI1	genetic	21127252
RTG3_YEAST	RTG3	genetic	21127252
HAP3_YEAST	HAP3	genetic	27708008
NPL4_YEAST	NPL4	genetic	27708008
RIF1_YEAST	RIF1	genetic	27708008
COX23_YEAST	COX23	genetic	27708008
MGA2_YEAST	MGA2	genetic	27708008
HAP4_YEAST	HAP4	genetic	27708008
ATP10_YEAST	ATP10	genetic	27708008
U5072_YEAST	YML002W	genetic	27708008
YMP8_YEAST	YMR018W	genetic	27708008
IRC23_YEAST	IRC23	genetic	27708008
RS10A_YEAST	RPS10A	genetic	27708008
MRX11_YEAST	YPL041C	genetic	27708008
MDL2_YEAST	MDL2	genetic	27708008
YME1_YEAST	YME1	genetic	27708008
MSS18_YEAST	MSS18	genetic	27708008
PHSG_YEAST	GPH1	genetic	27708008
BOR1_YEAST	BOR1	genetic	27453043
GCR2_YEAST	GCR2	genetic	27453043
DCOR_YEAST	SPE1	genetic	27453043
SYLM_YEAST	NAM2	genetic	27453043
DCAM_YEAST	SPE2	genetic	27453043
VPS53_YEAST	VPS53	genetic	27453043

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MRK1_YEAST

Related Literatures of Post-Translational Modification