| UniProt ID | TCPG_YEAST | |
|---|---|---|
| UniProt AC | P39077 | |
| Protein Name | T-complex protein 1 subunit gamma | |
| Gene Name | CCT3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 534 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.. | |
| Protein Sequence | MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRKQE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MQAPVVFM -------CCCCEEEE | 7.46 | 22814378 | |
| 11 | Phosphorylation | PVVFMNASQERTTGR CEEEEECCCCCCCCC | 27.80 | 30377154 | |
| 114 | Ubiquitination | CAPYLIEKNIHPVII HHHHHHHCCCCHHHH | 54.96 | 15699485 | |
| 130 | Phosphorylation | QALKKALTDALEVIK HHHHHHHHHHHHHHH | 24.88 | 21126336 | |
| 201 | Acetylation | PNFEIDIKRYVRVEK CCCEEEEEEEEEEEE | 33.65 | 24489116 | |
| 208 | Ubiquitination | KRYVRVEKIPGGDVL EEEEEEEECCCCCCC | 51.88 | 23749301 | |
| 227 | Acetylation | LKGVLLNKDVVHPKM HCHHHCCCCCCCHHH | 52.44 | 24489116 | |
| 253 | Acetylation | LDCPLEYKKGESQTN EECCCEECCCCCCCC | 44.95 | 24489116 | |
| 253 | Ubiquitination | LDCPLEYKKGESQTN EECCCEECCCCCCCC | 44.95 | 15699485 | |
| 254 | Ubiquitination | DCPLEYKKGESQTNI ECCCEECCCCCCCCC | 67.99 | 15699485 | |
| 257 | Phosphorylation | LEYKKGESQTNIEIE CEECCCCCCCCCEEE | 51.47 | 22369663 | |
| 259 | Phosphorylation | YKKGESQTNIEIEKE ECCCCCCCCCEEECH | 47.66 | 22369663 | |
| 265 | Acetylation | QTNIEIEKEEDWNRI CCCCEEECHHHHHHH | 72.56 | 24489116 | |
| 299 | Ubiquitination | PTLVITEKGVSDLAQ CEEEEECCCHHHHHH | 56.83 | 17644757 | |
| 302 | Phosphorylation | VITEKGVSDLAQHYL EEECCCHHHHHHHHH | 35.26 | 21440633 | |
| 311 | Ubiquitination | LAQHYLLKGGCSVLR HHHHHHHHCCCHHHH | 51.14 | 23749301 | |
| 311 | Acetylation | LAQHYLLKGGCSVLR HHHHHHHHCCCHHHH | 51.14 | 24489116 | |
| 344 | Acetylation | VNRVEDLKESDVGTN ECCHHHHHHCCCCCC | 68.44 | 24489116 | |
| 346 | Phosphorylation | RVEDLKESDVGTNCG CHHHHHHCCCCCCCE | 35.69 | 28889911 | |
| 350 | Phosphorylation | LKESDVGTNCGLFKV HHHCCCCCCCEEEEE | 27.47 | 28889911 | |
| 386 | Succinylation | IMLRGGSKDILNEID EEECCCCHHHHHHHH | 52.65 | 23954790 | |
| 386 | Acetylation | IMLRGGSKDILNEID EEECCCCHHHHHHHH | 52.65 | 24489116 | |
| 386 | Ubiquitination | IMLRGGSKDILNEID EEECCCCHHHHHHHH | 52.65 | 23749301 | |
| 481 | Phosphorylation | KHAQGNFTTGIDGDK HHCCCCCCCCCCCCC | 28.28 | 27017623 | |
| 506 | Acetylation | IWEPEVIKQQSVKTA CCCHHHHCHHHHHHH | 47.67 | 24489116 | |
| 506 | Ubiquitination | IWEPEVIKQQSVKTA CCCHHHHCHHHHHHH | 47.67 | 22817900 | |
| 509 | Phosphorylation | PEVIKQQSVKTAIES HHHHCHHHHHHHHHH | 24.08 | 27017623 | |
| 511 | Ubiquitination | VIKQQSVKTAIESAC HHCHHHHHHHHHHHH | 37.17 | 23749301 | |
| 528 | Phosphorylation | LRVDDIVSGVRKQE- HCHHHHHHCCCCCC- | 31.72 | 28132839 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TCPG_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TCPG_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TCPG_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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