| UniProt ID | COX15_YEAST | |
|---|---|---|
| UniProt AC | P40086 | |
| Protein Name | Cytochrome c oxidase assembly protein COX15 | |
| Gene Name | COX15 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 486 | |
| Subcellular Localization |
Mitochondrion inner membrane Multi-pass membrane protein . |
|
| Protein Description | Required for the assembly of yeast cytochrome oxidase. Involved in the biosynthesis of heme A and the initial step in this pathway, the hydroxylation of heme O, is thought to be catalyzed by a three-component mono-oxygenase consisting of COX15, ferredoxin and ferredoxin reductase.. | |
| Protein Sequence | MLFRNIEVGRQAAKLLTRTSSRLAWQSIGASRNISTIRQQIRKTQLYNFKKTVSIRPFSLSSPVFKPHVASESNPIESRLKTSKNVAYWLIGTSGLVFGIVVLGGLTRLTESGLSITEWKPVTGTLPPMNQKEWEEEFIKYKESPEFKLLNSHIDLDEFKFIFFMEWIHRLWGRAIGAVFILPAVYFAVSKKTSGHVNKRLFGLAGLLGLQGFVGWWMVKSGLDQEQLDARKSKPTVSQYRLTTHLGTAFFLYMGMLWTGLEILRECKWIKNPVQAISLFKKLDNPAIGPMRKISLALLAVSFLTAMSGGMVAGLDAGWVYNTWPKMGERWFPSSRELMDENFCRREDKKDLWWRNLLENPVTVQLVHRTCAYVAFTSVLAAHMYAIKKKAVIPRNAMTSLHVMMGVVTLQATLGILTILYLVPISLASIHQAGALALLTSSLVFASQLRKPRAPMRNVIITLPHSSKVTSGKILSEASKLASKPL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 281 | Acetylation | VQAISLFKKLDNPAI HHHHHHHHCCCCCCC | 58.69 | 24489116 | |
| 295 | Phosphorylation | IGPMRKISLALLAVS CCHHHHHHHHHHHHH | 15.60 | 19779198 | |
| 467 | Phosphorylation | IITLPHSSKVTSGKI EEECCCCCCCCCCCH | 28.28 | 28889911 | |
| 470 | Phosphorylation | LPHSSKVTSGKILSE CCCCCCCCCCCHHHH | 35.18 | 29688323 | |
| 471 | Phosphorylation | PHSSKVTSGKILSEA CCCCCCCCCCHHHHH | 40.87 | 29688323 | |
| 476 | Phosphorylation | VTSGKILSEASKLAS CCCCCHHHHHHHHHC | 34.29 | 29688323 | |
| 479 | Phosphorylation | GKILSEASKLASKPL CCHHHHHHHHHCCCC | 24.93 | 29688323 | |
| 483 | Phosphorylation | SEASKLASKPL---- HHHHHHHCCCC---- | 45.29 | 29688323 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of COX15_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of COX15_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of COX15_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
