MAK5_YEAST - dbPTM
MAK5_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MAK5_YEAST
UniProt AC P38112
Protein Name ATP-dependent RNA helicase MAK5
Gene Name MAK5
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 773
Subcellular Localization Nucleus, nucleolus .
Protein Description ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs. Required for the maintenance of dsRNA killer plasmid..
Protein Sequence MGKKRAPQKGKTVTKPQEIIVDESKLNWKPVDIPDTLDDFGGFYGLEEIDGVDVKVVDGKVTFVTKKDSKVLKDSNKEKVGDDQESVENESGSDSESELLEFKNLDDIKEGELSAASYSSSDEDEQGNIESSKLTDPSEDVDEDVDEDVLKENVFNKDINIDDISPVNLPEWTNLAPLSMTILQSLQNLNFLRPTEIQKKSIPVIMQGVDVMGKASTGSGKTLAYGIPIVEKLISNFSQKNKKPISLIFTPTRELAHQVTDHLKKICEPVLAKSQYSILSLTGGLSIQKQQRLLKYDNSGQIVIATPGRFLELLEKDNTLIKRFSKVNTLILDEADRLLQDGHFDEFEKIIKHLLVERRKNRENSEGSSKIWQTLIFSATFSIDLFDKLSSSRQVKDRRFKNNEDELNAVIQHLMSKIHFNSKPVIIDTNPESKVSSQIKESLIECPPLERDLYCYYFLTMFPGTTLIFCNAIDSVKKLTVYLNNLGIPAFQIHSSMTQKNRLKSLERFKQQSAKQKTINHSNPDSVQLSTVLIASDVAARGLDIPGVQHVIHYHLPRSTDIYIHRSGRTARAGSEGVSAMICSPQESMGPLRKLRKTLATKNSVSTDLNSRSTNRKPIKWQNTVPLLPIETDILSQLRERSRLAGELADHEIASNSLRKDDNWLKKAADELGIDVDSDEDDISKSNSDTFLLKNKNKKMQKTINKDKVKAMRATLNELLSVPIRKDRRQKYLTGGLVNLADNLVKKRGHNSIIGHEKTNALETLKKKKKRNN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationRAPQKGKTVTKPQEI
CCCCCCCCCCCCCEE		41.9229688323
14PhosphorylationPQKGKTVTKPQEIIV
CCCCCCCCCCCEEEE		42.0929688323
15AcetylationQKGKTVTKPQEIIVD
CCCCCCCCCCEEEEC		40.1324489116
24PhosphorylationQEIIVDESKLNWKPV
CEEEECHHHHCCEEC		37.6729688323
69PhosphorylationTFVTKKDSKVLKDSN
EEEECCCCCCCCCCC		33.2828889911
86PhosphorylationKVGDDQESVENESGS
CCCCCHHHHCCCCCC		29.1519795423
91PhosphorylationQESVENESGSDSESE
HHHHCCCCCCCCHHH		56.0019795423
93PhosphorylationSVENESGSDSESELL
HHCCCCCCCCHHHHH		47.4419795423
95PhosphorylationENESGSDSESELLEF
CCCCCCCCHHHHHEE		44.7319795423
97PhosphorylationESGSDSESELLEFKN
CCCCCCHHHHHEECC		37.1819795423
114PhosphorylationDIKEGELSAASYSSS
HHCCCCCCCCCCCCC		19.9319795423
117PhosphorylationEGELSAASYSSSDED
CCCCCCCCCCCCCCC		25.8419795423
118PhosphorylationGELSAASYSSSDEDE
CCCCCCCCCCCCCCC		14.0819795423
119PhosphorylationELSAASYSSSDEDEQ
CCCCCCCCCCCCCCC		22.3719795423
120PhosphorylationLSAASYSSSDEDEQG
CCCCCCCCCCCCCCC		33.3119795423
121PhosphorylationSAASYSSSDEDEQGN
CCCCCCCCCCCCCCC		38.7919795423
135PhosphorylationNIESSKLTDPSEDVD
CCCCCCCCCCCCCCC		49.9917330950
138PhosphorylationSSKLTDPSEDVDEDV
CCCCCCCCCCCCCCC		49.6022369663
436PhosphorylationTNPESKVSSQIKESL
CCCCHHHCHHHHHHH		21.9121126336
575PhosphorylationGRTARAGSEGVSAMI
CCCCCCCCCCCCEEE		30.1428889911
604PhosphorylationKTLATKNSVSTDLNS
HHHHHCCCCCCCCCC		20.9928889911
678PhosphorylationELGIDVDSDEDDISK
HHCCCCCCCCCHHHH		42.6322369663
684PhosphorylationDSDEDDISKSNSDTF
CCCCCHHHHCCCCCE		36.7122890988
686PhosphorylationDEDDISKSNSDTFLL
CCCHHHHCCCCCEEE		34.4722369663
688PhosphorylationDDISKSNSDTFLLKN
CHHHHCCCCCEEEEC		45.1522369663
690PhosphorylationISKSNSDTFLLKNKN
HHHCCCCCEEEECCC		18.9221440633
694AcetylationNSDTFLLKNKNKKMQ
CCCCEEEECCCHHHH		68.9425381059
703PhosphorylationKNKKMQKTINKDKVK
CCHHHHHHCCHHHHH		16.9421440633
752PhosphorylationVKKRGHNSIIGHEKT
HHHCCCCCCCCCHHH		15.2030377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MAK5_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MAK5_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MAK5_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CLU_YEASTCLU1physical
11805826
CYAA_YEASTCYR1physical
11805826
ERB1_YEASTERB1physical
11805826
GCN1_YEASTGCN1physical
11805826
HAS1_YEASTHAS1physical
11805826
NOG1_YEASTNOG1physical
11805826
NOP12_YEASTNOP12physical
11805826
NOP2_YEASTNOP2physical
11805826
NOP4_YEASTNOP4physical
11805826
RLP7_YEASTRLP7physical
11805826
SEC7_YEASTSEC7physical
11805826
SKI2_YEASTSKI2physical
11805826
PUF6_YEASTPUF6physical
11805826
NSA1_YEASTNSA1physical
11805826
URB1_YEASTURB1physical
11805826
INP2_YEASTINP2physical
11805826
YTM1_YEASTYTM1physical
11805826
RL30_YEASTRPL30physical
16429126
RS24A_YEASTRPS24Bphysical
16429126
RS24B_YEASTRPS24Bphysical
16429126
RS22B_YEASTRPS22Bphysical
16429126
RL36B_YEASTRPL36Bphysical
16429126
RL6A_YEASTRPL6Aphysical
16429126
ERB1_YEASTERB1physical
16429126
RL4A_YEASTRPL4Aphysical
16429126
RL7B_YEASTRPL7Bphysical
16429126
YTM1_YEASTYTM1physical
16429126
NOG1_YEASTNOG1physical
16429126
NOP2_YEASTNOP2physical
16429126
RLP7_YEASTRLP7physical
16429126
RL3_YEASTRPL3physical
16429126
RL25_YEASTRPL25physical
16429126
RLA0_YEASTRPP0physical
16429126
NOP4_YEASTNOP4physical
16429126
PUF6_YEASTPUF6physical
16429126
RL8B_YEASTRPL8Bphysical
16429126
IMDH2_YEASTIMD2physical
16429126
NOP12_YEASTNOP12physical
16429126
RRP5_YEASTRRP5physical
16429126
RL7A_YEASTRPL7Aphysical
16429126
URB1_YEASTURB1physical
16429126
HAS1_YEASTHAS1physical
16429126
NSA1_YEASTNSA1physical
16429126
RL23A_YEASTRPL23Aphysical
16429126
RL23B_YEASTRPL23Aphysical
16429126
RL5_YEASTRPL5physical
16429126
XRN1_YEASTXRN1genetic
6987655
SKI2_YEASTSKI2genetic
6987655
SKI3_YEASTSKI3genetic
6987655
CSL4_YEASTCSL4genetic
6987655
HAS1_YEASTHAS1physical
16449635
DBP6_YEASTDBP6physical
16449635
DOA1_YEASTDOA1genetic
19061648
LSM12_YEASTLSM12genetic
19061648
NOP16_YEASTNOP16genetic
19061648
ORN_YEASTREX2genetic
19061648
SNU66_YEASTSNU66genetic
19061648
RIX7_YEASTRIX7genetic
24312670
EBP2_YEASTEBP2genetic
24312670
NOP16_YEASTNOP16genetic
24312670
RPF1_YEASTRPF1genetic
24312670
RL14A_YEASTRPL14Agenetic
24312670
NOC2_YEASTNOC2physical
25877921
DBP10_YEASTDBP10physical
25877921
LOC1_YEASTLOC1physical
25877921
NOP4_YEASTNOP4physical
25877921
RLP7_YEASTRLP7physical
25877921
EBP2_YEASTEBP2physical
25877921
HAS1_YEASTHAS1physical
25877921
NSA2_YEASTNSA2physical
25877921
RPF1_YEASTRPF1physical
25877921
NOP12_YEASTNOP12physical
25877921
PSB7_YEASTPRE4genetic
27708008
TYSY_YEASTCDC21genetic
27708008
PET8_YEASTPET8genetic
27708008
RL21B_YEASTRPL21Bgenetic
27708008
HSP7F_YEASTSSE1genetic
27708008
MAK16_YEASTMAK16genetic
27708008
PRP9_YEASTPRP9genetic
27708008
CDC53_YEASTCDC53genetic
27708008
MAK21_YEASTMAK21genetic
27708008
ERF3_YEASTSUP35genetic
27708008
CDC4_YEASTCDC4genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
PMM_YEASTSEC53genetic
27708008
PESC_YEASTNOP7genetic
27708008
RRP41_YEASTSKI6genetic
27708008
CP51_YEASTERG11genetic
27708008
RRP4_YEASTRRP4genetic
27708008
RPF1_YEASTRPF1genetic
27708008
CDC12_YEASTCDC12genetic
27708008
MTR4_YEASTMTR4genetic
27708008
PRP21_YEASTPRP21genetic
27708008
ESS1_YEASTESS1genetic
27708008
MAK11_YEASTMAK11genetic
27708008
ABF1_YEASTABF1genetic
27708008
DBP9_YEASTDBP9genetic
27708008
ERB1_YEASTERB1genetic
27708008
RLP7_YEASTRLP7genetic
27708008
NOP2_YEASTNOP2genetic
27708008
BRX1_YEASTBRX1genetic
27708008
DYR_YEASTDFR1genetic
27708008
YTM1_YEASTYTM1genetic
27708008
NAB3_YEASTNAB3genetic
27708008
NIP7_YEASTNIP7genetic
27708008
YD180_YEASTYDL180Wgenetic
27708008
TPS2_YEASTTPS2genetic
27708008
SWF1_YEASTSWF1genetic
27708008
AIM11_YEASTAIM11genetic
27708008
RTR1_YEASTRTR1genetic
27708008
DBP3_YEASTDBP3genetic
27708008
MMS2_YEASTMMS2genetic
27708008
RTG2_YEASTRTG2genetic
27708008
RL26B_YEASTRPL26Bgenetic
27708008
SSF1_YEASTSSF1genetic
27708008
STB5_YEASTSTB5genetic
27708008
SDHX_YEASTYJL045Wgenetic
27708008
TCTP_YEASTTMA19genetic
27708008
DBR1_YEASTDBR1genetic
27708008
SRL3_YEASTSRL3genetic
27708008
SIC1_YEASTSIC1genetic
27708008
ELO3_YEASTELO3genetic
27708008
SUB1_YEASTSUB1genetic
27708008
GBLP_YEASTASC1genetic
27708008
TMA23_YEASTTMA23genetic
27708008
SPO1_YEASTSPO1genetic
27708008
YNE6_YEASTYNL046Wgenetic
27708008
CPT1_YEASTCPT1genetic
27708008
TOP1_YEASTTOP1genetic
27708008
REXO4_YEASTREX4genetic
27708008
RRP6_YEASTRRP6genetic
27708008
VAM10_YEASTVAM10genetic
27708008
VPS5_YEASTVPS5genetic
27708008
VPS21_YEASTVPS21genetic
27708008
RMI1_YEASTRMI1genetic
27708008
SUR1_YEASTSUR1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
YP022_YEASTYPR022Cgenetic
27708008
VPS4_YEASTVPS4genetic
27708008
NOP4_YEASTNOP4physical
27077951
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MAK5_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95; THR-135; SER-138;SER-575; SER-678 AND SER-688, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138 AND SER-678, ANDMASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-135; SER-138 ANDSER-678, AND MASS SPECTROMETRY.
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-678, AND MASSSPECTROMETRY.

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