RL23A_YEAST - dbPTM
RL23A_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RL23A_YEAST
UniProt AC P0CX41
Protein Name 60S ribosomal protein L23-A {ECO:0000303|PubMed:9559554}
Gene Name RPL23A {ECO:0000303|PubMed:9559554}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 137
Subcellular Localization Cytoplasm .
Protein Description Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel..
Protein Sequence MSGNGAQGTKFRISLGLPVGAIMNCADNSGARNLYIIAVKGSGSRLNRLPAASLGDMVMATVKKGKPELRKKVMPAIVVRQAKSWRRRDGVFLYFEDNAGVIANPKGEMKGSAITGPVGKECADLWPRVASNSGVVV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSGNGAQGT
------CCCCCCCCC		40.7522814378
10AcetylationGNGAQGTKFRISLGL
CCCCCCCCEEEEECC		39.2024489116
14PhosphorylationQGTKFRISLGLPVGA
CCCCEEEEECCCHHH		16.4821440633
25GlutathionylationPVGAIMNCADNSGAR
CHHHEEEECCCCCCC		2.5222833525
35PhosphorylationNSGARNLYIIAVKGS
CCCCCCEEEEEEECC		8.2021082442
42PhosphorylationYIIAVKGSGSRLNRL
EEEEEECCCCHHCCC		28.0722369663
44PhosphorylationIAVKGSGSRLNRLPA
EEEECCCCHHCCCCC		34.9822369663
53PhosphorylationLNRLPAASLGDMVMA
HCCCCCCHHHHHHHH		34.6821440633
61PhosphorylationLGDMVMATVKKGKPE
HHHHHHHHHHCCCHH		18.1122369663
63AcetylationDMVMATVKKGKPELR
HHHHHHHHCCCHHHH		51.9924489116
106MethylationAGVIANPKGEMKGSA
CEEEECCCCCCCCCE		68.2717327221
110MethylationANPKGEMKGSAITGP
ECCCCCCCCCEEECC		45.4717327221
110UbiquitinationANPKGEMKGSAITGP
ECCCCCCCCCEEECC		45.47-
112PhosphorylationPKGEMKGSAITGPVG
CCCCCCCCEEECCCC		15.8117287358
131PhosphorylationDLWPRVASNSGVVV-
HHCHHHHCCCCCCC-		28.7721440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RL23A_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
40KMethylation

16096273
106KMethylation

17327221
110KMethylation

17327221
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RL23A_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BCP1_YEASTBCP1physical
11805826
GFA1_YEASTGFA1physical
11805826
GLT1_YEASTGLT1physical
11805826
IMB4_YEASTKAP123physical
11805826
HSP74_YEASTSSA4physical
11805826
YO098_YEASTYOL098Cphysical
11805826
NOC2_YEASTNOC2physical
11805826
RKM1_YEASTRKM1physical
11805826
BCP1_YEASTBCP1physical
16429126
HSP74_YEASTSSA4physical
16429126
PYR1_YEASTURA2physical
16429126
YO098_YEASTYOL098Cphysical
16429126
RKM1_YEASTRKM1physical
16429126
GFA1_YEASTGFA1physical
16429126
GLT1_YEASTGLT1physical
16429126
IMB4_YEASTKAP123physical
16429126
RL6A_YEASTRPL6Aphysical
16429126
RS5_YEASTRPS5physical
16429126
NOC2_YEASTNOC2physical
16429126
RL5_YEASTRPL5physical
16429126
RL4B_YEASTRPL4Bphysical
16429126
SSB2_YEASTSSB2physical
16429126
GCN4_YEASTGCN4genetic
18423200
LTE1_YEASTLTE1genetic
20093466
GPX2_YEASTGPX2genetic
20093466
RV167_YEASTRVS167genetic
20093466
DOT1_YEASTDOT1genetic
20093466
BLM10_YEASTBLM10genetic
20093466
GCN20_YEASTGCN20genetic
20093466
UBP6_YEASTUBP6genetic
20093466
DSD1_YEASTDSD1genetic
20093466
DBF2_YEASTDBF2genetic
20093466
STB5_YEASTSTB5genetic
20093466
FMC1_YEASTFMC1genetic
20093466
LSM1_YEASTLSM1genetic
20093466
LDB18_YEASTLDB18genetic
20093466
YPT7_YEASTYPT7genetic
20093466
AIM34_YEASTAIM34genetic
20093466
BCH1_YEASTBCH1genetic
20093466
SWS2_YEASTSWS2genetic
20093466
MKS1_YEASTMKS1genetic
20093466
SIR2_YEASTSIR2genetic
21902802
RRP1_YEASTRRP1genetic
27708008
NCS1_YEASTFRQ1genetic
27708008
RMRP_YEASTSNM1genetic
27708008
ACT_YEASTACT1genetic
27708008
NU145_YEASTNUP145genetic
27708008
XPO1_YEASTCRM1genetic
27708008
FDFT_YEASTERG9genetic
27708008
ARP4_YEASTARP4genetic
27708008
CDC11_YEASTCDC11genetic
27708008
NOP56_YEASTNOP56genetic
27708008
SEC13_YEASTSEC13genetic
27708008
TAD3_YEASTTAD3genetic
27708008
MYO2_YEASTMYO2genetic
27708008
CDC10_YEASTCDC10genetic
27708008
NSE4_YEASTNSE4genetic
27708008
COPA_YEASTCOP1genetic
27708008
RPN5_YEASTRPN5genetic
27708008
DAD1_YEASTDAD1genetic
27708008
TAF12_YEASTTAF12genetic
27708008
CDC37_YEASTCDC37genetic
27708008
NSE3_YEASTNSE3genetic
27708008
BCP1_YEASTBCP1genetic
27708008
RSP5_YEASTRSP5genetic
27708008
SEC4_YEASTSEC4genetic
27708008
CDC4_YEASTCDC4genetic
27708008
MOB2_YEASTMOB2genetic
27708008
RPN11_YEASTRPN11genetic
27708008
RPN12_YEASTRPN12genetic
27708008
PSA1_YEASTSCL1genetic
27708008
PRS8_YEASTRPT6genetic
27708008
MPPA_YEASTMAS2genetic
27708008
BIG1_YEASTBIG1genetic
27708008
KOG1_YEASTKOG1genetic
27708008
ESS1_YEASTESS1genetic
27708008
KTHY_YEASTCDC8genetic
27708008
KCY_YEASTURA6genetic
27708008
ERG27_YEASTERG27genetic
27708008
RU1C_YEASTYHC1genetic
27708008
POB3_YEASTPOB3genetic
27708008
MED11_YEASTMED11genetic
27708008
CH10_YEASTHSP10genetic
27708008
DYR_YEASTDFR1genetic
27708008
COPZ_YEASTRET3genetic
27708008
IPL1_YEASTIPL1genetic
27708008
IF6_YEASTTIF6genetic
27708008
PSB5_YEASTPRE2genetic
27708008
SEC23_YEASTSEC23genetic
27708008
LTE1_YEASTLTE1genetic
27708008
UBC4_YEASTUBC4genetic
27708008
GPX2_YEASTGPX2genetic
27708008
IMG2_YEASTIMG2genetic
27708008
TPS2_YEASTTPS2genetic
27708008
NUM1_YEASTNUM1genetic
27708008
BCS1_YEASTBCS1genetic
27708008
DOT1_YEASTDOT1genetic
27708008
UBP6_YEASTUBP6genetic
27708008
DSD1_YEASTDSD1genetic
27708008
THP2_YEASTTHP2genetic
27708008
STB5_YEASTSTB5genetic
27708008
FMC1_YEASTFMC1genetic
27708008
MGA2_YEASTMGA2genetic
27708008
VPS24_YEASTVPS24genetic
27708008
LDB18_YEASTLDB18genetic
27708008
SIC1_YEASTSIC1genetic
27708008
COA4_YEASTCOA4genetic
27708008
BUD8_YEASTBUD8genetic
27708008
YNO0_YEASTYNL140Cgenetic
27708008
GGPPS_YEASTBTS1genetic
27708008
SUE1_YEASTSUE1genetic
27708008
BCP1_YEASTBCP1physical
27913624
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RL23A_YEAST

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"A novel SET domain methyltransferase modifies ribosomal proteinRpl23ab in yeast.";
Porras-Yakushi T.R., Whitelegge J.P., Miranda T.B., Clarke S.;
J. Biol. Chem. 280:34590-34598(2005).
Cited for: ACETYLATION AT SER-2, AND METHYLATION AT LYS-40; LYS-106 AND LYS-110.
Phosphorylation
ReferencePubMed
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-112, AND MASSSPECTROMETRY.

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