| UniProt ID | PRS8_YEAST | |
|---|---|---|
| UniProt AC | Q01939 | |
| Protein Name | 26S proteasome regulatory subunit 8 homolog | |
| Gene Name | RPT6 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 405 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).. | |
| Protein Sequence | MTAAVTSSNIVLETHESGIKPYFEQKIQETELKIRSKTENVRRLEAQRNALNDKVRFIKDELRLLQEPGSYVGEVIKIVSDKKVLVKVQPEGKYIVDVAKDINVKDLKASQRVCLRSDSYMLHKVLENKADPLVSLMMVEKVPDSTYDMVGGLTKQIKEIKEVIELPVKHPELFESLGIAQPKGVILYGPPGTGKTLLARAVAHHTDCKFIRVSGAELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSTRVEGSGGGDSEVQRTMLELLNQLDGFETSKNIKIIMATNRLDILDPALLRPGRIDRKIEFPPPSVAARAEILRIHSRKMNLTRGINLRKVAEKMNGCSGADVKGVCTEAGMYALRERRIHVTQEDFELAVGKVMNKNQETAISVAKLFK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MTAAVTSSN ------CCCEEECCC | 24.27 | 12504901 | |
| 59 | Acetylation | NDKVRFIKDELRLLQ HHHHHHHHHHHHHHC | 42.30 | 24489116 | |
| 77 | Acetylation | SYVGEVIKIVSDKKV CCHHHEEEEEECCEE | 42.08 | 24489116 | |
| 77 | Ubiquitination | SYVGEVIKIVSDKKV CCHHHEEEEEECCEE | 42.08 | 17644757 | |
| 93 | Acetylation | VKVQPEGKYIVDVAK EEECCCCCEEEEEEC | 30.09 | 24489116 | |
| 93 | Ubiquitination | VKVQPEGKYIVDVAK EEECCCCCEEEEEEC | 30.09 | 23749301 | |
| 100 | Ubiquitination | KYIVDVAKDINVKDL CEEEEEECCCCHHHC | 60.01 | 24961812 | |
| 100 | Acetylation | KYIVDVAKDINVKDL CEEEEEECCCCHHHC | 60.01 | 24489116 | |
| 119 | Phosphorylation | RVCLRSDSYMLHKVL CEEECCCCHHHHHHH | 17.43 | 28889911 | |
| 147 | Phosphorylation | EKVPDSTYDMVGGLT ECCCCCHHHHCCHHH | 13.14 | 27017623 | |
| 158 | Ubiquitination | GGLTKQIKEIKEVIE CHHHHHHHHHHHHHC | 51.39 | 17644757 | |
| 161 | Ubiquitination | TKQIKEIKEVIELPV HHHHHHHHHHHCCCC | 47.20 | 17644757 | |
| 161 | Succinylation | TKQIKEIKEVIELPV HHHHHHHHHHHCCCC | 47.20 | 23954790 | |
| 169 | Ubiquitination | EVIELPVKHPELFES HHHCCCCCCHHHHHH | 52.05 | 17644757 | |
| 183 | Ubiquitination | SLGIAQPKGVILYGP HCCCCCCCEEEEECC | 54.45 | 17644757 | |
| 193 | Phosphorylation | ILYGPPGTGKTLLAR EEECCCCCCHHHHHH | 41.08 | 27214570 | |
| 195 | Ubiquitination | YGPPGTGKTLLARAV ECCCCCCHHHHHHHH | 35.52 | 23749301 | |
| 195 | Acetylation | YGPPGTGKTLLARAV ECCCCCCHHHHHHHH | 35.52 | 24489116 | |
| 209 | Ubiquitination | VAHHTDCKFIRVSGA HHHCCCCCEEECCHH | 46.78 | 22817900 | |
| 209 | Acetylation | VAHHTDCKFIRVSGA HHHCCCCCEEECCHH | 46.78 | 22865919 | |
| 221 | Ubiquitination | SGAELVQKYIGEGSR CHHHHHHHHHCCCHH | 31.21 | 23749301 | |
| 221 | Acetylation | SGAELVQKYIGEGSR CHHHHHHHHHCCCHH | 31.21 | 24489116 | |
| 261 | Phosphorylation | GSTRVEGSGGGDSEV CCEECCCCCCCCHHH | 22.28 | 28889911 | |
| 286 | Ubiquitination | LDGFETSKNIKIIMA CCCCCCCCCEEEEEE | 70.84 | 23749301 | |
| 289 | Ubiquitination | FETSKNIKIIMATNR CCCCCCEEEEEECCC | 35.26 | 22817900 | |
| 313 | Ubiquitination | RPGRIDRKIEFPPPS CCCCCCCCCCCCCCH | 42.72 | 17644757 | |
| 320 | Phosphorylation | KIEFPPPSVAARAEI CCCCCCCHHHHHHHH | 30.11 | 24930733 | |
| 349 | Ubiquitination | NLRKVAEKMNGCSGA CHHHHHHHHCCCCCC | 28.11 | 23749301 | |
| 359 | Ubiquitination | GCSGADVKGVCTEAG CCCCCCHHHHHCHHH | 46.29 | 23749301 | |
| 378 | Phosphorylation | RERRIHVTQEDFELA HHCCCCCCHHHHHHH | 16.45 | 28889911 | |
| 388 | Ubiquitination | DFELAVGKVMNKNQE HHHHHHHHHCCCCHH | 31.54 | 17644757 | |
| 392 | Ubiquitination | AVGKVMNKNQETAIS HHHHHCCCCHHHHHH | 41.74 | 23749301 | |
| 402 | Ubiquitination | ETAISVAKLFK---- HHHHHHHHHCC---- | 52.91 | 23749301 | |
| 402 | Acetylation | ETAISVAKLFK---- HHHHHHHHHCC---- | 52.91 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PRS8_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PRS8_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PRS8_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Acetylation | |
| Reference | PubMed |
| "N-terminal modifications of the 19S regulatory particle subunits ofthe yeast proteasome."; Kimura Y., Saeki Y., Yokosawa H., Polevoda B., Sherman F., Hirano H.; Arch. Biochem. Biophys. 409:341-348(2003). Cited for: PROTEIN SEQUENCE OF 2-9, AND ACETYLATION AT THR-2. | |
