PDC2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDC2_YEAST
• UniProt AC: P32896
• Protein Name: Protein PDC2
• Gene Name: PDC2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 925
• Protein Description: Essential for the synthesis of pyruvate decarboxylase. May be important for a high basal level of PDC gene expression or play a positive role in the autoregulation control of PDC1 and PDC5..
• Protein Sequence: MLSIQQRYNICLMAERHPKWTQLELAKWAYETFQLPKIPSQGTISRLLARKSTYMNCKEHEKDANRLRKPNNLLVRKILQEWISQSLWNGIPITSPIIQDTAQAVWHRIPAEHREGNGSFSYKWISNFLSKMDVNISVLDEELPKTPKVWTFEERDVLKAYFSKIPPKDLFTLDEAFLSYNLPLDYAQYEASSIQRRIEVATVMLCSNLDGSEKLKPVVVGKYDSYKSFRNYFPNEPNDPVSQSMLGTKMAKKFDISYHSNRKAWLTSNLFHNWLVRWDKRLVAVNRKIWIVLDDSCCHRIINLRLQNIKLVYTSSNSKFLPFNWGVWDEFKTRYRIQQYQALIDLQNRISKNIQNKNKSERNECIPNGKKCLISFEQSQLTMSNAFKFIKKAWDDIPVDAIKANWKSSGLLPPEMIHLNENVSMAFKKNEVLESVLNRLCDEYYCVKKWEYEMLLDLNIENKNTNFLSTEELVESAIVEPCEPDFDTAPKGNEVHDDNFDVSVFANEDDNNQNHLSMSQASHNPDYNSNHSNNAIENTNNRGSNNNNNNNGSSNNINDNDSSVKYLQQNTVDNSTKTGNPGQPNISSMESQRNSSTTDLVVDGNYDVNFNGLLNDPYNTMKQPGPLDYNVSTLIDKPNLFLSPDLDLSTVGVDMQLPSSEYFSEVFSSAIRNNEKAASDQNKSTDELPSSTAMANSNSITTALLESRNQAQPFDVPHMNGLLSDTSKSGHSVNSSNAISQNSLNNFQHNSASVAEASSPSITPSPVAINSTGAPARSIISAPIDSNSSASSPSALEHLEGAVSGMSPSSTTILSNLQTNINIAKSLSTIMKHAESNEISLTKETINELNFNYLTLLKRIKKTRKQLNSESIKINSKNAQDHLETLLSGAAAAAATSANNLDLPTGGSNLPDSNNLHLPGNTGFF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	FQLPKIPSQGTISRL CCCCCCCCCCHHHHH	44.72	27214570
252	Ubiquitination	MLGTKMAKKFDISYH HHCHHHHHHCCCEEE	50.94	19722269
253	Ubiquitination	LGTKMAKKFDISYHS HCHHHHHHCCCEEEC	38.44	19722269
544	Phosphorylation	ENTNNRGSNNNNNNN CCCCCCCCCCCCCCC	32.90	22369663
553	Phosphorylation	NNNNNNGSSNNINDN CCCCCCCCCCCCCCC	31.83	22369663
554	Phosphorylation	NNNNNGSSNNINDND CCCCCCCCCCCCCCH	34.98	22369663
562	Phosphorylation	NNINDNDSSVKYLQQ CCCCCCHHHHHHHHH	43.20	22369663
563	Phosphorylation	NINDNDSSVKYLQQN CCCCCHHHHHHHHHH	26.03	22369663
565	Acetylation	NDNDSSVKYLQQNTV CCCHHHHHHHHHHCC	42.04	22865919
578	Phosphorylation	TVDNSTKTGNPGQPN CCCCCCCCCCCCCCC	42.13	27017623
588	Phosphorylation	PGQPNISSMESQRNS CCCCCCHHHCCCCCC	23.83	27017623
591	Phosphorylation	PNISSMESQRNSSTT CCCHHHCCCCCCCCC	26.29	27017623
595	Phosphorylation	SMESQRNSSTTDLVV HHCCCCCCCCCCEEE	31.11	29136822
596	Phosphorylation	MESQRNSSTTDLVVD HCCCCCCCCCCEEEC	38.58	29136822
597	Phosphorylation	ESQRNSSTTDLVVDG CCCCCCCCCCEEECC	24.93	29136822
598	Phosphorylation	SQRNSSTTDLVVDGN CCCCCCCCCEEECCC	29.32	29136822
606	Phosphorylation	DLVVDGNYDVNFNGL CEEECCCCCCCCCCC	27.14	29136822
618	Phosphorylation	NGLLNDPYNTMKQPG CCCCCCCCCCCCCCC	26.57	29136822
620	Phosphorylation	LLNDPYNTMKQPGPL CCCCCCCCCCCCCCC	21.65	29136822
622	Ubiquitination	NDPYNTMKQPGPLDY CCCCCCCCCCCCCCC	51.83	19722269
679	Phosphorylation	RNNEKAASDQNKSTD HCCHHHCCCCCCCCC	44.59	21440633
684	Phosphorylation	AASDQNKSTDELPSS HCCCCCCCCCCCCHH	48.95	22369663
685	Phosphorylation	ASDQNKSTDELPSST CCCCCCCCCCCCHHH	34.79	19779198
692	Phosphorylation	TDELPSSTAMANSNS CCCCCHHHHHHCCCC	25.45	22369663
697	Phosphorylation	SSTAMANSNSITTAL HHHHHHCCCCHHHHH	23.55	21440633
699	Phosphorylation	TAMANSNSITTALLE HHHHCCCCHHHHHHH	22.57	28152593
701	Phosphorylation	MANSNSITTALLESR HHCCCCHHHHHHHHC	13.06	27017623
724	Phosphorylation	PHMNGLLSDTSKSGH CCCCCCCCCCCCCCC	43.83	22369663
726	Phosphorylation	MNGLLSDTSKSGHSV CCCCCCCCCCCCCCC	34.38	22369663
727	Phosphorylation	NGLLSDTSKSGHSVN CCCCCCCCCCCCCCC	29.79	21440633
761	Phosphorylation	VAEASSPSITPSPVA HHHHCCCCCCCCCEE	40.83	21440633

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDC2_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDC2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDC2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PFKA1_YEAST	PFK1	genetic	9055069

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-684 AND SER-699, ANDMASS SPECTROMETRY.
PubMed: 18407956