RPE_YEAST - dbPTM
RPE_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RPE_YEAST
UniProt AC P46969
Protein Name Ribulose-phosphate 3-epimerase
Gene Name RPE1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 238
Subcellular Localization Cytoplasm.
Protein Description Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate (By similarity). Involved in the protective response to oxidative stress..
Protein Sequence MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRDLLD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
59PhosphorylationIVTSLRRSVPRPGDA
CHHHHHHCCCCCCCC		30.0022369663
67PhosphorylationVPRPGDASNTEKKPT
CCCCCCCCCCCCCCC		49.3722369663
69PhosphorylationRPGDASNTEKKPTAF
CCCCCCCCCCCCCEE		46.8422369663
116AcetylationQDPLHLVKLIKSKGI
CCHHHHHHHHHCCCC		51.3525381059
176AcetylationKVETLRAKFPHLNIQ
HHHHHHHHCCCCEEE		53.6624489116
221PhosphorylationADPHDVISFMKEEVS
CCHHHHHHHHHHHHH		21.0928889911
229AcetylationFMKEEVSKELRSRDL
HHHHHHHHHHHHCCC		66.9822865919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RPE_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RPE_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RPE_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RPE_YEASTRPE1physical
18719252
G6PD_YEASTZWF1genetic
17284612
G6PD_YEASTZWF1genetic
16941010
TAL2_YEASTNQM1genetic
16941010
TAL1_YEASTTAL1genetic
16941010
TKT1_YEASTTKL1genetic
16941010
TKT2_YEASTTKL2genetic
16941010
ALDH6_YEASTALD6genetic
21623372
IDHC_YEASTIDP2genetic
21623372
ARGJ_YEASTARG7genetic
21623372
THRC_YEASTTHR4genetic
21623372
AROC_YEASTARO2genetic
21623372
QCR7_YEASTQCR7genetic
21623372
ARO1_YEASTARO1genetic
21623372
IPK1_YEASTIPK1genetic
21623372
SYSM_YEASTDIA4genetic
21623372
KAD2_YEASTADK1genetic
21623372
PRP6_YEASTPRP6genetic
27708008
CDC24_YEASTCDC24genetic
27708008
RPAB1_YEASTRPB5genetic
27708008
CDK1_YEASTCDC28genetic
27708008
TECR_YEASTTSC13genetic
27708008
RPN6_YEASTRPN6genetic
27708008
UAP1_YEASTQRI1genetic
27708008
RPB1_YEASTRPO21genetic
27708008
RPC10_YEASTRPC11genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
ACT_YEASTACT1genetic
27708008
PRS8_YEASTRPT6genetic
27708008
PRP18_YEASTPRP18genetic
27708008
TEL2_YEASTTEL2genetic
27708008
YHI0_YEASTYHR020Wgenetic
27708008
CDC12_YEASTCDC12genetic
27708008
MET30_YEASTMET30genetic
27708008
ARPC5_YEASTARC15genetic
27708008
SEC13_YEASTSEC13genetic
27708008
SEC22_YEASTSEC22genetic
27708008
LST8_YEASTLST8genetic
27708008
ARPC2_YEASTARC35genetic
27708008
DED1_YEASTDED1genetic
27708008
GPI2_YEASTGPI2genetic
27708008
PSB5_YEASTPRE2genetic
27708008
BUR1_YEASTSGV1genetic
27708008
ECM8_YEASTECM8genetic
27708008
RV161_YEASTRVS161genetic
27708008
OCA4_YEASTOCA4genetic
27708008
TPS2_YEASTTPS2genetic
27708008
ARO1_YEASTARO1genetic
27708008
UME6_YEASTUME6genetic
27708008
RAD4_YEASTRAD4genetic
27708008
SA155_YEASTSAP155genetic
27708008
PIB2_YEASTPIB2genetic
27708008
SGF73_YEASTSGF73genetic
27708008
AROC_YEASTARO2genetic
27708008
VMA21_YEASTVMA21genetic
27708008
PSA3_YEASTPRE9genetic
27708008
STB5_YEASTSTB5genetic
27708008
LST4_YEASTLST4genetic
27708008
SAC1_YEASTSAC1genetic
27708008
EIF3J_YEASTHCR1genetic
27708008
ERG6_YEASTERG6genetic
27708008
VPS9_YEASTVPS9genetic
27708008
GTR1_YEASTGTR1genetic
27708008
SIW14_YEASTSIW14genetic
27708008
SIN3_YEASTSIN3genetic
27708008
HRK1_YEASTHRK1genetic
27708008
ALDH6_YEASTALD6genetic
27708008
RU2A_YEASTLEA1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RPE_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-221, AND MASSSPECTROMETRY.

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