| UniProt ID | SEC13_YEAST | |
|---|---|---|
| UniProt AC | Q04491 | |
| Protein Name | Protein transport protein SEC13 | |
| Gene Name | SEC13 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 297 | |
| Subcellular Localization |
Cytoplasmic vesicle, COPII-coated vesicle membrane Peripheral membrane protein Cytoplasmic side. Endoplasmic reticulum membrane Peripheral membrane protein Cytoplasmic side. Nucleus, nuclear pore complex. Vacuole membrane Peripheral membrane protein. |
|
| Protein Description | Functions as a component of the nuclear pore complex (NPC) and the COPII coat. It is one of 5 proteins constituting the COPII coat, which is involved in anterograde (ER to Golgi) double-membrane transport vesicle formation. First the small GTPase SAR1, activated by and binding to the integral ER membrane protein SEC12, exchanges GDP for GTP and recruits the heterodimer SEC23/24, which in turn recruits the heterotetramer SEC13-SEC31. The polymerization of COPII coat complexes then causes physically the deformation (budding) of the membrane, leading to the creation of a transport vesicle. The COPII complex is dissociated upon SAR1-GTP hydrolysis to SAR1-GDP. SEC23 functions as the SAR1 GTPase activating protein, whose activity is stimulated in the presence of SEC13/31. SEC13 is directly or indirectly required for normal ER membrane and nuclear envelope morphology. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution. Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis.. | |
| Protein Sequence | MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 31 | Acetylation | LATCSSDKTIKIFEV EEECCCCCEEEEEEE | 54.84 | 25381059 | |
| 44 | Acetylation | EVEGETHKLIDTLTG EEECCEEEEEHHHCC | 55.33 | 24489116 | |
| 65 | Acetylation | RVDWAHPKFGTILAS EEEECCCCCCEEEEE | 46.70 | 24489116 | |
| 83 | Acetylation | DGKVLIWKEENGRWS CCCEEEEEEECCCEE | 48.43 | 24489116 | |
| 83 | Succinylation | DGKVLIWKEENGRWS CCCEEEEEEECCCEE | 48.43 | 23954790 | |
| 172 | Ubiquitination | NGTKESRKFVTGGAD CCCHHHHEEECCCCC | 54.16 | 23749301 | |
| 244 | Acetylation | DNEQGPWKKTLLKEE CCCCCCCCHHHCCCC | 38.73 | 24489116 | |
| 249 | Acetylation | PWKKTLLKEEKFPDV CCCHHHCCCCCCCCH | 67.92 | 24489116 | |
| 252 | Acetylation | KTLLKEEKFPDVLWR HHHCCCCCCCCHHHH | 64.39 | 24489116 | |
| 282 | Acetylation | DNKVTLWKENLEGKW CCEEEEEEECCCCCC | 39.58 | 24489116 | |
| 288 | Acetylation | WKENLEGKWEPAGEV EEECCCCCCEECCCC | 38.72 | 24489116 | |
| 288 | Succinylation | WKENLEGKWEPAGEV EEECCCCCCEECCCC | 38.72 | 23954790 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SEC13_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SEC13_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SEC13_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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