| UniProt ID | SEC31_YEAST | |
|---|---|---|
| UniProt AC | P38968 | |
| Protein Name | Protein transport protein SEC31 | |
| Gene Name | SEC31 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1273 | |
| Subcellular Localization |
Cytoplasmic vesicle, COPII-coated vesicle membrane Peripheral membrane protein Cytoplasmic side. Endoplasmic reticulum membrane Peripheral membrane protein Cytoplasmic side. |
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| Protein Description | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.. | |
| Protein Sequence | MVKLAEFSRTATFAWSHDKIPLLVSGTVSGTVDANFSTDSSLELWSLLAADSEKPIASLQVDSKFNDLDWSHNNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQFPARGNWCFKTKFAPEAPDLFACASFDNKIEVQTLQNLTNTLDEQETETKQQESETDFWNNVSREESKEKPTVFHLQAPTWYGEPSPAAHWAFGGKLVQITPDGKGVSITNPKISGLESNTTLSEALKTKDFKPLINQRLVKVIDDVNEEDWNLLEKLSMDGTEEFLKEALAFDNDESDAQDDANNEKEDDGEEFFQQIETNFQPEGDFSLSGNIEQTISKNLVSGNIKSAVKNSLENDLLMEAMVIALDSNNERLKESVKNAYFAKYGSKSSLSRILYSISKREVDDLVENLDVSQWKFISKAIQNLYPNDIAQRNEMLIKLGDRLKENGHRQDSLTLYLAAGSLDKVASIWLSEFPDLEDKLKKDNKTIYEAHSECLTEFIERFTVFSNFINGSSTINNEQLIAKFLEFINLTTSTGNFELATEFLNSLPSDNEEVKTEKARVLIASGKSLPAQNPATATTSKAKYTNAKTNKNVPVLPTPGMPSTTSIPSMQAPFYGMTPGASANALPPKPYVPATTTSAPVHTEGKYAPPSQPSMASPFVNKTNSSTRLNSFAPPPNPYATATVPATNVSTTSIPQNTFAPIQPGMPIMGDYNAQSSSIPSQPPINAVSGQTPHLNRKANDGWNDLPLKVKEKPSRAKAVSVAPPNILSTPTPLNGIPANAASTMPPPPLSRAPSSVSMVSPPPLHKNSRVPSLVATSESPRASISNPYAPPQSSQQFPIGTISTANQTSNTAQVASSNPYAPPPQQRVATPLSGGVPPAPLPKASNPYAPTATTQPNGSSYPPTGPYTNNHTMTSPPPVFNKPPTGPPPISMKKRSNKLASIEQNPSQGATYPPTLSSSASPLQPSQPPTLASQVNTSAENVSHEIPADQQPIVDFLKEELARVTPLTPKEYSKQLKDCDKRLKILFYHLEKQDLLTQPTIDCLHDLVALMKEKKYKEAMVIHANIATNHAQEGGNWLTGVKRLIGIAEATLN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 247 | Phosphorylation | WDLRNANTPLQTLNQ EECCCCCCCCCCCHH | 23.98 | 23749301 | |
| 349 | Phosphorylation | TETKQQESETDFWNN HHHHHHHHHHHHHHC | 41.27 | 22369663 | |
| 351 | Phosphorylation | TKQQESETDFWNNVS HHHHHHHHHHHHCCC | 45.86 | 25521595 | |
| 358 | Phosphorylation | TDFWNNVSREESKEK HHHHHCCCHHHHCCC | 35.78 | 22369663 | |
| 362 | Phosphorylation | NNVSREESKEKPTVF HCCCHHHHCCCCCEE | 41.17 | 20377248 | |
| 396 | Phosphorylation | GGKLVQITPDGKGVS CCEEEEECCCCCCEE | 9.76 | 22369663 | |
| 403 | Phosphorylation | TPDGKGVSITNPKIS CCCCCCEECCCCCCC | 32.15 | 19823750 | |
| 405 | Phosphorylation | DGKGVSITNPKISGL CCCCEECCCCCCCCC | 37.65 | 19823750 | |
| 408 | Acetylation | GVSITNPKISGLESN CEECCCCCCCCCCCC | 52.12 | 24489116 | |
| 414 | Phosphorylation | PKISGLESNTTLSEA CCCCCCCCCCCHHHH | 44.51 | 25752575 | |
| 416 | Phosphorylation | ISGLESNTTLSEALK CCCCCCCCCHHHHHC | 38.09 | 24961812 | |
| 417 | Phosphorylation | SGLESNTTLSEALKT CCCCCCCCHHHHHCC | 32.32 | 24961812 | |
| 419 | Phosphorylation | LESNTTLSEALKTKD CCCCCCHHHHHCCCC | 20.80 | 24961812 | |
| 424 | Phosphorylation | TLSEALKTKDFKPLI CHHHHHCCCCCHHHH | 36.37 | 28889911 | |
| 428 | Acetylation | ALKTKDFKPLINQRL HHCCCCCHHHHCHHH | 49.39 | 22865919 | |
| 454 | Phosphorylation | WNLLEKLSMDGTEEF HHHHHHHCCCCHHHH | 26.37 | 22369663 | |
| 458 | Phosphorylation | EKLSMDGTEEFLKEA HHHCCCCHHHHHHHH | 28.25 | 28889911 | |
| 473 | Phosphorylation | LAFDNDESDAQDDAN HCCCCCCCCCCCCCC | 40.90 | 22369663 | |
| 525 | Phosphorylation | LVSGNIKSAVKNSLE CCCCCHHHHHHHHHH | 34.20 | 23749301 | |
| 562 | Acetylation | VKNAYFAKYGSKSSL HHHHHHHHHCCHHHH | 40.00 | 22865919 | |
| 566 | Ubiquitination | YFAKYGSKSSLSRIL HHHHHCCHHHHHHHH | 39.44 | 23749301 | |
| 567 | Phosphorylation | FAKYGSKSSLSRILY HHHHCCHHHHHHHHH | 37.90 | 23749301 | |
| 598 | Ubiquitination | SQWKFISKAIQNLYP HHHHHHHHHHHHHCC | 44.70 | 23749301 | |
| 598 | Acetylation | SQWKFISKAIQNLYP HHHHHHHHHHHHHCC | 44.70 | 24489116 | |
| 617 | Acetylation | QRNEMLIKLGDRLKE HHHHHHHHHHHHHHH | 42.32 | 24489116 | |
| 728 | Phosphorylation | EFLNSLPSDNEEVKT HHHHCCCCCCHHHHH | 59.36 | 27214570 | |
| 744 | Phosphorylation | KARVLIASGKSLPAQ HHHEEEECCCCCCCC | 39.50 | 30377154 | |
| 746 | Ubiquitination | RVLIASGKSLPAQNP HEEEECCCCCCCCCC | 46.45 | 23749301 | |
| 747 | Phosphorylation | VLIASGKSLPAQNPA EEEECCCCCCCCCCC | 43.01 | 23749301 | |
| 759 | Phosphorylation | NPATATTSKAKYTNA CCCCCCCCCHHCCCC | 26.68 | 23749301 | |
| 782 | Phosphorylation | LPTPGMPSTTSIPSM CCCCCCCCCCCCCCC | 35.11 | 21551504 | |
| 783 | Phosphorylation | PTPGMPSTTSIPSMQ CCCCCCCCCCCCCCC | 20.77 | 21551504 | |
| 785 | Phosphorylation | PGMPSTTSIPSMQAP CCCCCCCCCCCCCCC | 32.37 | 21551504 | |
| 825 | Acetylation | APVHTEGKYAPPSQP CCCCCCCCCCCCCCC | 31.82 | 22865919 | |
| 826 | Phosphorylation | PVHTEGKYAPPSQPS CCCCCCCCCCCCCCC | 34.89 | 29688323 | |
| 830 | Phosphorylation | EGKYAPPSQPSMASP CCCCCCCCCCCCCCC | 54.38 | 22369663 | |
| 833 | Phosphorylation | YAPPSQPSMASPFVN CCCCCCCCCCCCCCC | 21.24 | 24909858 | |
| 834 | Oxidation | APPSQPSMASPFVNK CCCCCCCCCCCCCCC | 5.64 | 15665377 | |
| 836 | Phosphorylation | PSQPSMASPFVNKTN CCCCCCCCCCCCCCC | 15.38 | 22369663 | |
| 841 | Acetylation | MASPFVNKTNSSTRL CCCCCCCCCCCCCCC | 43.72 | 24489116 | |
| 842 | Phosphorylation | ASPFVNKTNSSTRLN CCCCCCCCCCCCCCC | 34.82 | 25752575 | |
| 844 | Phosphorylation | PFVNKTNSSTRLNSF CCCCCCCCCCCCCCC | 38.01 | 17563356 | |
| 845 | Phosphorylation | FVNKTNSSTRLNSFA CCCCCCCCCCCCCCC | 21.44 | 29136822 | |
| 846 | Phosphorylation | VNKTNSSTRLNSFAP CCCCCCCCCCCCCCC | 38.71 | 25752575 | |
| 928 | Acetylation | GWNDLPLKVKEKPSR CCCCCCCCCCCCCCC | 49.69 | 24489116 | |
| 962 | Phosphorylation | GIPANAASTMPPPPL CCCCCCHHCCCCCCC | 23.87 | 21440633 | |
| 970 | Phosphorylation | TMPPPPLSRAPSSVS CCCCCCCCCCCCCCC | 31.97 | 20377248 | |
| 974 | Phosphorylation | PPLSRAPSSVSMVSP CCCCCCCCCCCCCCC | 42.24 | 22369663 | |
| 975 | Phosphorylation | PLSRAPSSVSMVSPP CCCCCCCCCCCCCCC | 19.70 | 22369663 | |
| 977 | Phosphorylation | SRAPSSVSMVSPPPL CCCCCCCCCCCCCCC | 18.53 | 22369663 | |
| 980 | Phosphorylation | PSSVSMVSPPPLHKN CCCCCCCCCCCCCCC | 24.05 | 22369663 | |
| 988 | Phosphorylation | PPPLHKNSRVPSLVA CCCCCCCCCCCCEEE | 39.18 | 22369663 | |
| 992 | Phosphorylation | HKNSRVPSLVATSES CCCCCCCCEEECCCC | 32.39 | 22369663 | |
| 996 | Phosphorylation | RVPSLVATSESPRAS CCCCEEECCCCCCCC | 26.08 | 22369663 | |
| 997 | Phosphorylation | VPSLVATSESPRASI CCCEEECCCCCCCCC | 26.75 | 22369663 | |
| 999 | Phosphorylation | SLVATSESPRASISN CEEECCCCCCCCCCC | 21.32 | 22369663 | |
| 1050 | Phosphorylation | PPQQRVATPLSGGVP CCHHCCCCCCCCCCC | 23.16 | 22369663 | |
| 1053 | Phosphorylation | QRVATPLSGGVPPAP HCCCCCCCCCCCCCC | 34.40 | 22369663 | |
| 1084 | Phosphorylation | NGSSYPPTGPYTNNH CCCCCCCCCCCCCCC | 46.41 | 27738172 | |
| 1088 | Phosphorylation | YPPTGPYTNNHTMTS CCCCCCCCCCCCCCC | 32.45 | 27738172 | |
| 1157 | Phosphorylation | TLASQVNTSAENVSH CHHHHCCCCCHHCCC | 30.38 | 28889911 | |
| 1158 | Phosphorylation | LASQVNTSAENVSHE HHHHCCCCCHHCCCC | 28.51 | 27214570 | |
| 1185 | Phosphorylation | KEELARVTPLTPKEY HHHHHCCCCCCHHHH | 13.66 | 29136822 | |
| 1188 | Phosphorylation | LARVTPLTPKEYSKQ HHCCCCCCHHHHHHH | 33.25 | 29136822 | |
| 1232 | Ubiquitination | HDLVALMKEKKYKEA HHHHHHHHHHCHHEE | 68.20 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SEC31_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SEC31_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SEC31_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-992; SER-999; THR-1050AND SER-1053, AND MASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-396; SER-836; SER-999AND THR-1050, AND MASS SPECTROMETRY. | |
| "Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-974; SER-977; SER-980;SER-992 AND SER-999, AND MASS SPECTROMETRY. | |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-349; THR-396; SER-414;SER-728; SER-830; SER-836; SER-974; SER-975; SER-977; SER-980;SER-992; THR-996; SER-997; SER-999; THR-1050; SER-1053; THR-1157 ANDSER-1158, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-844; SER-974 ANDSER-975, AND MASS SPECTROMETRY. | |
